Laser-induced enhancement of transdermal drug delivery for lidocaine through hairless mouse skin

Takeyuki Uchizono; Kunio Awazu

doi:10.1117/12.645594

23 February 2006 Laser-induced enhancement of transdermal drug delivery for lidocaine through hairless mouse skin

Takeyuki Uchizono, Kunio Awazu

Proceedings Volume 6087, Biophotonics and Immune Responses; 60870Q (2006) https://doi.org/10.1117/12.645594
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Transdermal drug delivery system (TDDS), which is one of drug delivery system (DDS) for increasing the effectiveness of drugs, is enhanced absorption of drugs by laser irradiation. The purpose of this study is to investigate the optimum laser parameter for enhancing TDD and to examine the mechanism of TDD enhancement. In this study, hairless mouse skins (in vitro) were irradiated with Er:YAG laser, Nd:YAG laser and free electron laser (FEL), which were set up energy density of 0.5 J/cm²/pulse and exposure time of 5 second. We examined the flux (μg/cm²/h) of lidocaine (C₁₄H₂₂N₂O, FW: 234.38) through the skins using high pressure liquid chromatography (HPLC), observed cross section of the irradiated samples using light microscope, and measured electrical resistance of the surface of skins. The HPLC results demonstrated that the TDD of the irradiated samples was enhanced 200-350 times faster than it of the non-irradiated samples. It of Nd:YAG laser, however, had no enhancement. The observation of cross section and the electrical resistance of skins were found to not remove the stratum corneum (SC), completely. These results show that laser irradiations, which has the strong absorption to skins, enhance TDD dramatically with low invasive.

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Takeyuki Uchizono and Kunio Awazu "Laser-induced enhancement of transdermal drug delivery for lidocaine through hairless mouse skin", Proc. SPIE 6087, Biophotonics and Immune Responses, 60870Q (23 February 2006); https://doi.org/10.1117/12.645594

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KEYWORDS

Skin

Free electron lasers

Resistance

Er:YAG lasers

Nd:YAG lasers

Laser irradiation

Absorption

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