A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment

Tung-Wah Frederick Chang; Mari Boesen; Robert Weersink; Luc Charron; Edward H. Sargent; Lothar Lilge

doi:10.1117/12.701274

28 February 2007 A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment

Tung-Wah Frederick Chang, Mari Boesen, Robert Weersink, Luc Charron, Edward H. Sargent, Lothar Lilge

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 64271B (2007) https://doi.org/10.1117/12.701274
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Multi-sensory fiber-optic probes using nanocrystals as the sensing materials are shown to overcome most limitations imposed by those using organic dyes as the fluence-rate sensing materials. These nanocrystals are shown to be excitable by a wide range of wavelengths covering the entire tissue transparent window utilized by various light-enabled treatment modalities. The optical response of the sensors made from the nanocrystals is shown to be linear without any sign of photobleaching and sensor crosstalk over a wide range of irradiance and fluence. Fiber probes using the nanocrystals are promising in offering high spatial resolution in fluence-rate dosimetry for photodynamic therapy and photothermal treatment.

Citation Download Citation

Tung-Wah Frederick Chang, Mari Boesen, Robert Weersink, Luc Charron, Edward H. Sargent, and Lothar Lilge "A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64271B (28 February 2007); https://doi.org/10.1117/12.701274

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available