Prof. Robert A. Weersink Profile

Prof. Robert A. Weersink

Professor at Univ Health Network

SPIE Involvement:

Author

Publications (32)

Proceedings Article | 13 March 2024 Presentation + Paper

Photoacoustic thermometry system enabled by diffuse optical tomography for quantitative thermal guidance during photothermal therapy of solid tumors

Ivan Kosik, Robert Weersink, Ben Motz, Brian Wilson

Proceedings Volume 12834, 1283406 (2024) https://doi.org/10.1117/12.3003545

KEYWORDS: Tumors, Thermometry, Optical properties, Tissue optics, Sensors, Diffuse optical tomography, Scattering, Photoacoustic spectroscopy

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Proceedings Article | 14 March 2023 Poster + Paper

Photoacoustic imaging of pure temperature during photothermal therapy for cancer: a key treatment guidance element for clinical translation

Ivan Kosik, Robert Weersink, Sangeet Ghai, Theodore Husby, Andrew Effat, Brian Wilson

Proceedings Volume PC12379, PC123791Z (2023) https://doi.org/10.1117/12.2650785

KEYWORDS: Thermometry, Calibration, Magnetic resonance imaging, Imaging systems, Photoacoustic imaging, Cancer, Tumors, Oncology

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Proceedings Article | 3 October 2022 Presentation + Paper

Photoacoustic methods for direct monitoring of nanoparticle enhanced photothermal ablation in biological tissues: visualizing scattering, absorption, and thermal effects

Ivan Kosik, Robert Weersink, Brian Wilson

Proceedings Volume 12216, 122160E (2022) https://doi.org/10.1117/12.2638115

KEYWORDS: Tissues, Thermometry, Nanoparticles, Imaging systems, Magnetic resonance imaging, Tumors, Absorption, Visualization, Photoacoustic spectroscopy, Cancer

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Proceedings Article | 4 March 2022 Presentation + Paper

Measurement of intact and dissociated porphyrin-lipid nanoparticle concentration in tissue using diffuse reflectance and fluorescence spectroscopy

Theo Husby, Michael Valic, Gang Zheng, Brian Wilson, Robert Weersink

Proceedings Volume 11938, 1193806 (2022) https://doi.org/10.1117/12.2609870

KEYWORDS: Luminescence, Absorption, Reflectivity, Diffuse reflectance spectroscopy, Positron emission tomography, Scattering, Tumors, Tissue optics, Light emitting diodes

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SPIE Journal Paper | 1 February 2022 Open Access

Preclinical evaluation of a clinical prototype transrectal diffuse optical tomography system for monitoring photothermal therapy of focal prostate cancer

Celina Li, Carl Fisher, Brian Wilson, Robert Weersink

JBO, Vol. 27, Issue 02, 026001, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.026001

KEYWORDS: Tissues, Optical properties, Prostate, Laser coagulation, Diffuse optical tomography, In vivo imaging, Prototyping, Magnetic resonance imaging, Reconstruction algorithms, Absorption

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Proceedings Article | 12 March 2021 Presentation + Paper

A comparison of two probes to determine rectum optical properties

Andrew Li, Yi Hong Ong, Celina Li, Jie He, Andreea Dimofte, Theresa Busch, Brian Wilson, Robert Weersink, Timothy Zhu

Proceedings Volume 11628, 1162808 (2021) https://doi.org/10.1117/12.2582395

KEYWORDS: Optical properties, Rectum, Tissue optics, Solids, Sensors, Liquids, Finite element methods, Tumors, Transmittance, Prostate

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Proceedings Article | 27 February 2019 Paper

Pre-clinical validation of transrectal diffuse optical tomography for monitoring photocoagulation progression during photothermal therapy of prostate cancer

Celina Li, Carl Fisher, Runjie Bill Shi, Brian Wilson, Jie He, Gang Zheng, Robert Weersink

Proceedings Volume 10871, 1087115 (2019) https://doi.org/10.1117/12.2509059

KEYWORDS: Diffuse optical tomography, Prostate, In vivo imaging, Reflectivity, Laser coagulation, Sensors, Tissue optics, Optical properties, Magnetic resonance imaging, Thermometry, Signal detection

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Proceedings Article | 26 February 2019 Presentation + Paper

Assessment of optical detection methods for coagulation-front monitoring photothermal therapy of prostate cancer

Carl Fisher, Robert Weersink, Alexander Gregor, Alyssa Goldstein, Liang Lim, Michael Valic, Juan Chen, Rosanna Chan, Gang Zheng, Brian Wilson

Proceedings Volume 10852, 1085209 (2019) https://doi.org/10.1117/12.2509004

KEYWORDS: Prostate, Magnetic resonance imaging, Tissues, In vivo imaging, Tissue optics, Prostate cancer, Optical fibers, Thermometry, Laser therapeutics

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Proceedings Article | 29 August 2017 Paper

Photodynamic therapy for periodontal disease

Robert Weersink

Proceedings Volume 10313, 1031331 (2017) https://doi.org/10.1117/12.2283905

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Proceedings Article | 29 August 2017 Paper

Determination of in vivo photosensitizer concentrations using diffuse reflectance measurements and associative learning techniques

Robert Weersink

Proceedings Volume 10313, 103132B (2017) https://doi.org/10.1117/12.2283879

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SPIE Journal Paper | 6 April 2017 Open Access

Shape-based reconstruction for transrectal diffuse optical tomography monitoring of photothermal focal therapy of prostate cancer: simulation studies

Robert Weersink, Sahil Chaudhary, Kenwrick Mayo, Jie He, Brian Wilson

JBO, Vol. 22, Issue 04, 045004, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.045004

KEYWORDS: Optical properties, Prostate, Scattering, Sensors, Tissue optics, Absorption, Rectum, Tissues, Diffuse optical tomography, Reconstruction algorithms

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SPIE Journal Paper | 27 July 2015 Open Access

Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma

Emilie Chamma, Jimmy Qiu, Liis Lindvere-Teene, Kristina Blackmore, Safa Majeed, Robert Weersink, Colleen Dickie, Anthony Griffin, Jay Wunder, Peter Ferguson, Ralph DaCosta

JBO, Vol. 20, Issue 07, 076011, (July 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.7.076011

KEYWORDS: Atrial fibrillation, Skin, Tissue optics, Computed tomography, Bacteria, Luminescence, Surgery, Soft tissue optics, Cameras, Optical tracking

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Proceedings Article | 25 March 2013 Paper

Development of transrectal diffuse optical tomography combined with 3D-transrectal ultrasound imaging to monitor the photocoagulation front during interstitial photothermal therapy of primary focal prostate cancer

Jie He, Robert Weersink, Israel Veilleux, Kenwrick Mayo, Anqi Zhang, Daqing Piao, Adeel Alam, John Trachtenberg, Brian Wilson

Proceedings Volume 8578, 85781J (2013) https://doi.org/10.1117/12.2004457

KEYWORDS: Tissue optics, Sensors, Scattering, Laser therapeutics, Optical properties, Prostate cancer, Reconstruction algorithms, Signal detection, Laser coagulation, Tissues

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Proceedings Article | 25 March 2013 Paper

Monitoring changes in tissue optical properties following interstitial photothermal therapy of ex vivo human prostate tissue

Robert Weersink, Jie He, Israel Veilleux, John Trachtenberg, Brian Wilson

Proceedings Volume 8578, 85781G (2013) https://doi.org/10.1117/12.2004578

KEYWORDS: Prostate, Optical properties, Tissue optics, Tissues, Scattering, Diffuse reflectance spectroscopy, Absorption, Optical testing, Laser therapeutics, Reflectivity

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SPIE Journal Paper | 1 November 2010 Open Access

Assessment of thermal coagulation in ex-vivo tissues using Raman spectroscopy

Matthew Rodrigues, Robert Weersink, William Whelan

JBO, Vol. 15, Issue 06, 068001, (November 2010) https://doi.org/10.1117/12.10.1117/1.3512231

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Proceedings Article | 3 March 2010 Paper

Fusion of intraoperative cone-beam CT and endoscopic video for image-guided procedures

M. Daly, H. Chan, E. Prisman, A. Vescan, S. Nithiananthan, J. Qiu, R. Weersink, J. Irish, J. Siewerdsen

Proceedings Volume 7625, 762503 (2010) https://doi.org/10.1117/12.844212

KEYWORDS: Endoscopy, Image registration, Endoscopes, Video, Calibration, Head, Optical tracking, Neck, Cameras, Imaging systems

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Proceedings Article | 23 March 2007 Paper

Vascular-targeted photodynamic of prostate cancer phase with Tookad for recurrent prostate cancer following radiation therapy: initial clinical studies

Robert Weersink, Brian Wilson, Arjen Bogaards, Mark Gertner, Sean Davidson, Masoom Haider, Mostafa Elhilali, John Trachtenberg

Proceedings Volume 6424, 64241E (2007) https://doi.org/10.1117/12.704398

KEYWORDS: Prostate, Photodynamic therapy, Prostate cancer, Tissues, Optical fibers, Radiotherapy, Magnetic resonance imaging, Rectum, Biopsy, Safety

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Proceedings Article | 28 February 2007 Paper

A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment

Tung-Wah Frederick Chang, Mari Boesen, Robert Weersink, Luc Charron, Edward Sargent, Lothar Lilge

Proceedings Volume 6427, 64271B (2007) https://doi.org/10.1117/12.701274

KEYWORDS: Nanocrystals, Luminescence, Photodynamic therapy, Sensors, Epoxies, Fiber optics, Absorption, Tissue optics, Head, Spatial resolution

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Proceedings Article | 27 February 2007 Paper

Quantum dots as contrast agents for endoscopy: mathematical modeling and experimental validation of the optimal excitation wavelength

Mathieu Roy, Ralph DaCosta, Robert Weersink, George Netchev, Sean R. H. Davidson, Warren Chan, Brian Wilson

Proceedings Volume 6448, 644812 (2007) https://doi.org/10.1117/12.700954

KEYWORDS: Tissues, Mathematical modeling, Atrial fibrillation, Lung, Natural surfaces, Liver, Kidney, Luminescence, Brain, Absorption

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Proceedings Article | 27 February 2007 Paper

Conformal light delivery using tailored cylindrical diffusers

A. Rendon, J. Okawa, R. Weersink, J. Beck, Lothar Lilge

Proceedings Volume 6427, 64270M (2007) https://doi.org/10.1117/12.700996

KEYWORDS: Diffusers, Spatial frequencies, Optical properties, Inverse problems, Linear filtering, Manufacturing, Algorithms, Modulation, Light scattering, Scattering

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Proceedings Article | 21 February 2007 Paper

Light dosimetry for low-level laser therapy: accounting for differences in tissue and depth

Robert Weersink, Roger White, Lothar Lilge

Proceedings Volume 6428, 642803 (2007) https://doi.org/10.1117/12.713053

KEYWORDS: Tissue optics, Tissues, Monte Carlo methods, Natural surfaces, Diffuse reflectance spectroscopy, Optical properties, Reflectivity, Light, Laser therapeutics, Head

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Proceedings Article | 13 October 2005 Paper

Characterization of breast tissue composition and breast cancer risk assessment using non-invasive transillumination breast spectroscopy (TIBS)

Kristina Blackmore, Robert Weersink, Lothar Lilge

Proceedings Volume 5969, 59691L (2005) https://doi.org/10.1117/12.628666

KEYWORDS: Tissues, Breast, Tissue optics, Chromophores, Scattering, Breast cancer, Oxygen, Error analysis, Spectroscopy, Optical properties

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SPIE Journal Paper | 1 May 2005 Open Access

Photodynamic therapy for the treatment of metastatic lesions in bone: Studies in rat and porcine models

Shane Burch, Arjun Bogaards, Jeffrey Siewerdsen, Douglas Moseley, Albert Yee, J. Finkelstein, Robert Weersink, Brian Wilson, Stuart Bisland

JBO, Vol. 10, Issue 03, 034011, (May 2005) https://doi.org/10.1117/12.10.1117/1.1921887

KEYWORDS: Photodynamic therapy, Bone, Tumors, Spine, Spinal cord, Tissues, Tumor growth modeling, Breast cancer, Bioluminescence, Cancer

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Proceedings Article | 8 April 2005 Paper

Techniques for delivery and monitoring of TOOKAD(WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities

Robert Weersink, Arjen Bogaards, Mark Gertner, Sean Davidson, Kai Zhang, George Netchev, John Trachtenberg, Brian Wilson

Proceedings Volume 5689, (2005) https://doi.org/10.1117/12.589700

KEYWORDS: Prostate, Optical fibers, Photodynamic therapy, Optical properties, Tissue optics, Absorption, Sensors, Blood, Light, Tissues

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Proceedings Article | 9 December 2004 Paper

Optical delivery and monitoring of photodynamic therapy of prostate cancer

Robert Weersink, Arjun Bogaards, Mark Gertner, Sean Davidson, Kai Zhang, George Netchev, David Giewercer, John Trachtenberg, Brian Wilson

Proceedings Volume 5578, (2004) https://doi.org/10.1117/12.567665

KEYWORDS: Optical fibers, Prostate, Photodynamic therapy, Optical properties, Absorption, Tissue optics, Sensors, Blood, Tissues, Light

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Proceedings Article | 6 June 2002 Paper

Treatment planning platform for photodynamic therapy: architecture, function, and validation

Brian Wilson, William Whelan, Sean Davidson, Robert Weersink, Michael Sherar

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469335

KEYWORDS: Photodynamic therapy, Optical fibers, Tissue optics, Tissues, Prostate, Optical properties, Finite element methods, Light, Prostate cancer, Tumors

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Proceedings Article | 1 May 2002 Paper

Determination of in vivo photosensitizer concentrations using diffuse reflectance measurements and associative learning techniques

Robert Weersink, Brian Wilson, Michael Patterson

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465238

KEYWORDS: Tissues, Tissue optics, Diffuse reflectance spectroscopy, Absorption, Picosecond phenomena, Chromophores, Optical properties, Scattering, In vivo imaging, Neural networks

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Proceedings Article | 1 May 2002 Paper

Determination of the peak absorption wavelength and disaggregation kinetics of TOOKAD in vivo using dynamic, spatially resolved diffuse reflectance spectroscopy in a rabbit model

Robert Weersink, Brian Wilson, Michael Patterson

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465239

KEYWORDS: Absorption, Blood, In vivo imaging, Diffuse reflectance spectroscopy, Skin, Reflectivity, Factor analysis, Silver, Plasma, Tissues

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Proceedings Article | 19 April 2000 Paper

Validation of self-reported skin color via analysis of diffuse reflectance spectra of skin

Robert Weersink, Lorraine Marrett, Lothar Lilge, Mark Purdue, Stephen Walter

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382739

KEYWORDS: Skin, Neural networks, Reflectivity, Principal component analysis, Diffuse reflectance spectroscopy, Skin cancer, Sun, Absorption, Spectrophotometry, Cancer

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Proceedings Article | 15 July 1999 Paper

Estimation of the optical properties of two-layered tissue simulating phantoms from spatially resolved frequency-domain reflectance

George Alexandrakis, Robert Weersink, Jody Bruulsema, Michael Patterson

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356806

KEYWORDS: Optical properties, Diffusion, Absorption, Reflectivity, Data modeling, Tissue optics, Scattering, Skin, Tissues, Signal detection

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Proceedings Article | 16 June 1997 Paper

Changes in fluorescence emission during PDT due to photobleaching: potential usefulness as a marker of tissue damage

Robert Hawkes, Thomas Farrell, Michael Patterson, Robert Weersink

Proceedings Volume 2975, (1997) https://doi.org/10.1117/12.275482

KEYWORDS: Luminescence, Tissue optics, Absorption, Photodynamic therapy, Tissues, Mathematical modeling, Scattering, Light scattering, Natural surfaces, Light

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