Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C. L. Black; Ji Yi; José G. Rivera; Daria C. Zelasko-Leon; Phillip B. Messersmith

doi:10.1117/12.2005041

12 April 2013 Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C. L. Black, Ji Yi, José G. Rivera, Daria C. Zelasko-Leon, Phillip B. Messersmith

Author Affiliations +

Proceedings Volume 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices; 85980D (2013) https://doi.org/10.1117/12.2005041
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

Citation Download Citation

Kvar C. L. Black, Ji Yi, José G. Rivera, Daria C. Zelasko-Leon, and Phillip B. Messersmith "Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy", Proc. SPIE 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, 85980D (12 April 2013); https://doi.org/10.1117/12.2005041

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