A biosensor of high-density lipoprotein of human serum on a liquid crystal and polymer composite film

Yi-Hsin Lin; Kai-Han Chang; Wei-Lin Chu; Yu-Shih Tsou; Li-Ching Wu; Chien-Feng Li

doi:10.1117/12.2025382

1 October 2013 A biosensor of high-density lipoprotein of human serum on a liquid crystal and polymer composite film

Yi-Hsin Lin, Kai-Han Chang, Wei-Lin Chu, Yu-Shih Tsou, Li-Ching Wu, Chien-Feng Li

Proceedings Volume 8828, Liquid Crystals XVII; 88280I (2013) https://doi.org/10.1117/12.2025382
Event: SPIE Organic Photonics + Electronics, 2013, San Diego, California, United States

Abstract

A biosensor for the concentration of high-density lipoprotein (HDL) in human serum on a liquid crystal and polymer composite film (LCPCF) is demonstrated. The sensing mechanism is based on a polar-polar interaction between orientation of LC directors and HDL in human serum. The concentration of polar HDL in human serum affects the orientations of LC directors at the interface between LCPCF and the human serum. In addition, the surface free energy of LCPCF changes with the applied voltage due to the electrically tunable orientations of LC directors anchored among the polymer grains of LCPCF. As a result, the droplet motion of human serum on LCPCF under applied voltages can sense the concentration of HDL in human serum.

Citation Download Citation

Yi-Hsin Lin, Kai-Han Chang, Wei-Lin Chu, Yu-Shih Tsou, Li-Ching Wu, and Chien-Feng Li "A biosensor of high-density lipoprotein of human serum on a liquid crystal and polymer composite film", Proc. SPIE 8828, Liquid Crystals XVII, 88280I (1 October 2013); https://doi.org/10.1117/12.2025382

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