Low cost flatbed scanner label-free biosensor

Ugur Aygun; Oguzhan Avci; Elif Seymour; Derin D. Sevenler; Hakan Urey; M. Selim Ünlü; Ayca Yalcin Ozkumur

doi:10.1117/12.2214113

7 March 2016 Low cost flatbed scanner label-free biosensor

Ugur Aygun, Oguzhan Avci, Elif Seymour, Derin D. Sevenler, Hakan Urey, M. Selim Ünlü, Ayca Yalcin Ozkumur

Proceedings Volume 9699, Optics and Biophotonics in Low-Resource Settings II; 969906 (2016) https://doi.org/10.1117/12.2214113
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for highthroughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with ~10μm lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems.

Conference Presentation

Citation Download Citation

Ugur Aygun, Oguzhan Avci, Elif Seymour, Derin D. Sevenler, Hakan Urey, M. Selim Ünlü, and Ayca Yalcin Ozkumur "Low cost flatbed scanner label-free biosensor", Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969906 (7 March 2016); https://doi.org/10.1117/12.2214113

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available