Metasurface-enhanced infrared reflection spectroscopy of live cells: integrating microfluidics with plasmonics for drug screening

Gennady B. Shvets

doi:10.1117/12.2633139

13 October 2022 Metasurface-enhanced infrared reflection spectroscopy of live cells: integrating microfluidics with plasmonics for drug screening

Gennady B. Shvets

Author Affiliations +

Proceedings Volume PC12197, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XX; PC1219709 (2022) https://doi.org/10.1117/12.2633139
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States

Abstract

The ability to monitor the effects of external stimuli, such as drugs and other compounds, on a living cell, is of great interest for life sciences. It is especially desirable to do this all-optically and without introducing any external labels. I will describe such an experimental technique developed in our lab – Metasurface-Enhanced Infrared Reflection Spectroscopy (MEIRS) of live cells – that we have used to interrogating the effects of various chemical compounds (including chemotherapeutics) on cellular membranes and cytoskeleton. The prospects for expanding the scope of MEIRS to high-throughput drug screening will be discussed.

Conference Presentation

Citation Download Citation

Gennady B. Shvets "Metasurface-enhanced infrared reflection spectroscopy of live cells: integrating microfluidics with plasmonics for drug screening", Proc. SPIE PC12197, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XX, PC1219709 (13 October 2022); https://doi.org/10.1117/12.2633139

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