Utilization of near infrared cranial nerve-specific fluorophores intraoperatively for visualization enhancement

Anas M. Masillati; Antonio Montaño; Lei Wang; Connor Barth; Dani Szafran-Reeder; Summer L. Gibbs

doi:10.1117/12.2650869

17 March 2023 Utilization of near infrared cranial nerve-specific fluorophores intraoperatively for visualization enhancement

Anas M. Masillati, Antonio Montaño, Lei Wang, Connor Barth, Dani Szafran-Reeder, Summer L. Gibbs

Author Affiliations +

Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610L (2023) https://doi.org/10.1117/12.2650869
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cranial and spinal nerve repair occurs at a very slow rate, and in most cases the iatrogenic injury can’t be fully repaired, leading to permanent motor or sensory disabilities as well as incurable neuropathies. The visualization and evaluation of tumor-involved nerves is extremely difficult during minimally invasive surgical procedures such as through at the skull base. Recently, our group developed a library of nerve-specific near infrared (NIR) oxazine scaffold dyes that have high specificity for cranial nerves, and the ability to permeate the Blood-Brain Barrier (BBB), which resulted in different degrees of the obtained cranial nerves SBR. These cranial nerve-specific fluorophores will significantly improve nerve visualization at depth, enhancing the ability to visualize and evaluate buried and tumor-involved cranial nerves. This could significantly decrease post-surgical morbidity rates and could solve the unmet clinical need for an intraoperative tool that enhances visualization.

Conference Presentation

Citation Download Citation

Anas M. Masillati, Antonio Montaño, Lei Wang, Connor Barth, Dani Szafran-Reeder, and Summer L. Gibbs "Utilization of near infrared cranial nerve-specific fluorophores intraoperatively for visualization enhancement", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610L (17 March 2023); https://doi.org/10.1117/12.2650869

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