Absolute measurement of blood flow using a wide-field cerebral metabolic imaging (CMI) system

Thinh Phan; Christian Crouzet; Gordon T. Kennedy; Anthony J. Durkin; Bernard Choi

doi:10.1117/12.2648084

17 March 2023 Absolute measurement of blood flow using a wide-field cerebral metabolic imaging (CMI) system

Thinh Phan, Christian Crouzet, Gordon T. Kennedy, Anthony J. Durkin, Bernard Choi

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC1236502 (2023) https://doi.org/10.1117/12.2648084
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Previous work established that optical properties (absorption (μa) and reduced scattering (μs’) coefficients) can affect speckle contrast, and hence blood-flow measurements. Here, we introduce a cerebral metabolic imaging system that combines laser speckle imaging and spatial frequency domain imaging for rodents. Using measured optical properties and speckle contrast values, we developed a method of achieving absolute measurements of cerebral blood flow (CBF) using the correlation diffusion. We tested our approach with a mouse hindpaw stimulation model and observed a more substantial increase in peak CBF than conventional speckle contrast analysis.

Conference Presentation

Citation Download Citation

Thinh Phan, Christian Crouzet, Gordon T. Kennedy, Anthony J. Durkin, and Bernard Choi "Absolute measurement of blood flow using a wide-field cerebral metabolic imaging (CMI) system", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC1236502 (17 March 2023); https://doi.org/10.1117/12.2648084

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available