Investigation of neurodegeneration in the human organoid retina with transmission matrix measurements
 (Conference Presentation)

Jürgen W. Czarske; Nektarios Koukourakis; Stefan Rothe; Felix Wagner; Mike O. Karl

doi:10.1117/12.2661936

16 March 2023 Investigation of neurodegeneration in the human organoid retina with transmission matrix measurements (Conference Presentation)

Jürgen W. Czarske, Nektarios Koukourakis, Stefan Rothe, Felix Wagner, Mike O. Karl

Author Affiliations +

Proceedings Volume PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX; PC123880E (2023) https://doi.org/10.1117/12.2661936
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Adaptive optics and wavefront control enable advances in the transmission matrix measurement. However, despite its rich information content, the transmission matrix is usually only used to enhance light transmission through scattering media. For the first time, we present an assessment of the health status of retinal tissues using the transmission matrix measured by digital holography. Our data show that transmission matrix analysis can detect pathological changes in the retina and is promising for the development of label-free imaging biomarkers.

Conference Presentation

Citation Download Citation

Jürgen W. Czarske, Nektarios Koukourakis, Stefan Rothe, Felix Wagner, and Mike O. Karl "Investigation of neurodegeneration in the human organoid retina with transmission matrix measurements (Conference Presentation)", Proc. SPIE PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX, PC123880E (16 March 2023); https://doi.org/10.1117/12.2661936

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