Can near infrared nerve-specific imaging assess nerve integrity?

Anas M. Masillati; Antonio R. Montaño; Connor W. Barth; Lei G. Wang; Summer L. Gibbs

doi:10.1117/12.3004839

13 March 2024 Can near infrared nerve-specific imaging assess nerve integrity?

Anas M. Masillati, Antonio R. Montaño, Connor W. Barth, Lei G. Wang, Summer L. Gibbs

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250I (2024) https://doi.org/10.1117/12.3004839
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Iatrogenic nerve injuries are a major concern in various surgical fields, causing significant morbidity. These injuries lead to impaired sensory and motor functions, chronic pain, reduced limb control, and increased healthcare needs. Surgeons use techniques like white light visualization and intraoperative neuromonitoring (e.g., electromyography [EMG]) to identify nerve damage. However, the incidence rate remains high, necessitating better alternatives. Our team developed near-infrared (NIR) nerve-specific fluorophores to enhance nerve visualization, and one of our lead fluorophores exhibited reduced fluorescence intensity in injured nerve regions, providing contrast shortly after nerve injury. These results led us to hypothesize that the fluorophore could be used as an intraoperative neuromonitoring tool during fluorescence-guided surgery. Ultimately, this tool can be used intraoperatively to aid surgeons in timely detection and accurate assessment of nerve health, mitigating complications and improving patient outcomes. The culmination of our work will bring forth a novel methodology for localizing nerve injuries, benefiting both patients and surgical procedures.

Conference Presentation

Citation Download Citation

Anas M. Masillati, Antonio R. Montaño, Connor W. Barth, Lei G. Wang, and Summer L. Gibbs "Can near infrared nerve-specific imaging assess nerve integrity?", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250I (13 March 2024); https://doi.org/10.1117/12.3004839

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