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13 March 2024 The effect of radiation therapy on the growth rate of prostate tumor spheroids studied with dynamic contrast line-field optical coherence tomography (LF-dOCT)
Stephanie Swanson, Keyu Chen, Saduni U. S. Sumithrarachchige Don, Ernest Osei, Kostadinka Bizheva
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Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC1284106 (2024) https://doi.org/10.1117/12.3005670
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Prostate cancer is the most prevalent cancer among Canadian men and is often treated with radiation therapy. Historically, cancer has been studied using 2D cell culture methods, but recently 3D cell culture methods like tumor spheroids have been become popular to better replicate the physiological environment of the body. We developed ultrahigh resolution line-field OCT (LF-OCT) technology and a dynamic OCT (dOCT) method to image tumor spheroids and identify areas of necrosis, for comparison with computer simulation. The LF-OCT system has sufficient spatial resolution to identify individual cells and capture the cellular level of activity while the dOCT algorithm can resolve the dynamic activity accurately. The study will be extended to investigate the spatial and temporal development of necrosis in PC3 prostate tumor spheroids after irradiation. These results will be used to inform and extend the model to an in vivo environment.
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Stephanie Swanson, Keyu Chen, Saduni U. S. Sumithrarachchige Don, Ernest Osei, and Kostadinka Bizheva "The effect of radiation therapy on the growth rate of prostate tumor spheroids studied with dynamic contrast line-field optical coherence tomography (LF-dOCT)", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC1284106 (13 March 2024); https://doi.org/10.1117/12.3005670
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KEYWORDS
Tumors
Optical coherence tomography
Radiotherapy
Prostate
Radiation effects
Cancer
Computer simulations
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