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A high resolution all optical 3D photoacoustic scanner for superficial vascular imaging has been employed in a pilot study on patients with Peripheral Arterial Disease (PAD). The system can reliably produce high quality in-vivo photoacoustic images and is well tolerated by patients. The scanner can visualise the irregular vascular patterns in patients. In addition, by comparing the microvasculature of healthy volunteers and participants with CLTI we have demonstrated significant differences in the tortuosity, vessel size and vascular density between the 2 groups. The ability to visualise the lower limb microvasculature in detail in this way could be used to study small vessel-PAD linked to diseases such as diabetes with a view to informing diagnosis and treatment decision making.
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Nam Huynh, Jiaqi Zhu, Rachel Fox, Edward Zhang, Ben Cox, Janice Tsui, Conrad Von Stempel, Paul Beard, "Peripheral arterial disease assessment using the Fabry Perot photoacoustic scanner," Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420H (13 March 2024); https://doi.org/10.1117/12.3009000