Dr. Alan L. Huston Profile

Dr. Alan L. Huston

Research Chemist at US Naval Research Lab

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Author

Publications (19)

Proceedings Article | 7 March 2019 Presentation + Paper

Controlled membrane depolarization through photothermal effects of tethered gold nanoparticles

Megan Muroski, Okhil Nag, Eunkeu Oh, Alan Huston, James Delehanty

Proceedings Volume 10892, 108920M (2019) https://doi.org/10.1117/12.2508662

KEYWORDS: Nanoparticles, Gold, Plasmonics, Photothermal effect, Tumors, Nanomaterials, Live cell imaging, Statistical analysis, Action potentials, Neurons

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Proceedings Article | 23 February 2018 Presentation + Paper

Nanoparticle bioconjugate for controlled cellular delivery of doxorubicin

Ajmeeta Sangtani, Eleonora Petryayeva, Miao Wu, Kimihiro Susumu, Eunkeu Oh, Alan Huston, Guillermo Lasarte-Aragones, Igor Medintz, W. Russ Algar, James Delehanty

Proceedings Volume 10507, 105070M (2018) https://doi.org/10.1117/12.2290031

KEYWORDS: Toxicity, Nanoparticles, Modulation, Chemistry, Control systems, Quantum dots

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Proceedings Article | 28 April 2016 Presentation

Energy transfer sensitization of luminescent gold nanoclusters: more than just the classical Forster mechanism (Conference Presentation)

Eunkeu Oh, Alan Huston, Andrew Shabaev, Alexander Efros, Marc Currie, Kimihiro Susumu, Konrad Bussmann, Ramasis Goswami, Fredrik Fatemi, Igor Medintz

Proceedings Volume 9722, 97220F (2016) https://doi.org/10.1117/12.2212733

KEYWORDS: Energy transfer, Gold, Data modeling, Energy efficiency, Fluorescence resonance energy transfer, Nanocrystals, Metals, Semiconductors, Quantum dots, Nanolithography

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Proceedings Article | 22 April 2016 Paper

Imaging cellular membrane potential through ionization of quantum dots

Clare Rowland, Kimihiro Susumu, Michael Stewart, Eunkeu Oh, Antti Mäkinen, Thomas O'Shaughnessy, Gary Kushto, Mason Wolak, Jeffrey Erickson, Alexander Efros, Alan Huston, James Delehanty

Proceedings Volume 9722, 97220S (2016) https://doi.org/10.1117/12.2207337

KEYWORDS: Quantum dots, Ionization, Action potentials, Absorption, Luminescence, Neurons, Brain, Electrodes, Silica, Capacitors

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Proceedings Article | 12 March 2015 Paper

Membrane-targeting peptides for nanoparticle-facilitated cellular imaging and analysis

Joyce Breger, James Delehanty, Kelly Boeneman Gemmill, Lauren Field, Juan Blanco-Canosa, Philip Dawson, Alan Huston, Igor Medintz

Proceedings Volume 9338, 93381P (2015) https://doi.org/10.1117/12.2077026

KEYWORDS: Plasma, Nanoparticles, Luminescence, Analytical research, Quantum dots, Nanomaterials, Metals, Zinc, Biological research, Physiology

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Proceedings Article | 10 March 2015 Paper

Visualization and neuronal cell targeting during electrophysiological recordings facilitated by quantum dots

Lauren Field, Bertalan Andrásfalvy, Gregorio Galiñanes, Daniel Huber, Mladen Barbic, John Macklin, Kimihiro Susumu, James Delehanty, Alan Huston, Judit Makara, Igor Medintz

Proceedings Volume 9305, 93050Y (2015) https://doi.org/10.1117/12.2076934

KEYWORDS: Neurons, Visualization, Quantum dots, Plasma, Tissues, Brain, In vivo imaging, Coating, Thin film coatings, Physiology

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Proceedings Article | 1 October 2013 Paper

Improving energy transfer in QD-DNA photonic networks

Susan Buckhout-White, Christopher Spillmann, Mario Ancona, W. Russ Algar, Michael Stewart, Kimihiro Susumu, Alan Huston, Ellen Goldman, Igor Medintz

Proceedings Volume 8817, 88170J (2013) https://doi.org/10.1117/12.2024574

KEYWORDS: Fluorescence resonance energy transfer, Energy transfer, Chromophores, Excitons, Quantum dots, Resonance energy transfer, Thulium, Analytical research, Chemistry, Nanostructures

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Proceedings Article | 29 May 2013 Paper

Peptide-mediated cellular delivery of semiconductor quantum dots

Kelly Boeneman Gemmill, Markus Muttenthaler, James Delehanty, Jeff Deschamps, Kimihiro Susumu, Michael Stewart, Philip Dawson, Alan Huston, Igor Medintz

Proceedings Volume 8723, 872311 (2013) https://doi.org/10.1117/12.2015446

KEYWORDS: Quantum dots, Nanoparticles, Biosensing, Semiconductors, Proteins, Image analysis, Mirrors, Toxicity, Fluorescent proteins, In vitro testing

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Proceedings Article | 22 February 2013 Paper

Recent development of dihydrolipoic acid appended ligands for robust and biocompatible quantum dots

Kimihiro Susumu, Eunkeu Oh, Michael Stewart, James Delehanty, Kelly Gemmill, Vaibhav Jain, Alan Huston, Igor Medintz

Proceedings Volume 8595, 859515 (2013) https://doi.org/10.1117/12.2004952

KEYWORDS: Luminescence, Quantum dots, Proteins, Nanoparticles, Quantum efficiency, Zinc, Semiconductors, Coating, Adsorption, Biosensing

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Proceedings Article | 2 February 2012 Paper

Further progress in cytosolic cellular delivery of quantum dots

Kelly Boeneman Gemmill, James Delehanty, Michael Stewart, Kimihiro Susumu, Juan Blanco-Canosa, Philip Dawson, Alan Huston, Igor Medintz

Proceedings Volume 8232, 82320B (2012) https://doi.org/10.1117/12.906801

KEYWORDS: Quantum dots, Nanoparticles, Proteins, Biosensing, Toxicity, Luminescence, Polymers, Manufacturing, Zinc, In vivo imaging

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Proceedings Article | 12 February 2011 Paper

Quantum dots as a FRET donor and nanoscaffold for multivalent DNA photonic wires

Kelly Boeneman, Duane Prasuhn, Juan Blanco-Canosa, Philip Dawson, Joseph Melinger, Mario Ancona, Michael Stewart, Kimihiro Susumu, Alan Huston, Igor Medintz

Proceedings Volume 7909, 79090R (2011) https://doi.org/10.1117/12.879272

KEYWORDS: Fluorescence resonance energy transfer, Energy transfer, Quantum efficiency, DNA photonics, Quantum dots, Energy efficiency, Quenching (fluorescence), Composites, Chromophores, Absorption

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Proceedings Article | 5 May 2010 Paper

Quantum dots in life sciences: applications, benefits, and safety issues

James Delehanty, Christopher Bradburne, Kelly Boeneman, Kimihiro Susumu, Bing Mei, Juan Blanco-Canosa, Phillip Dawson, Hedi Mattoussi, Alan Huston, Igor Medintz

Proceedings Volume 7666, 766619 (2010) https://doi.org/10.1117/12.853121

KEYWORDS: Quantum dots, Life sciences, Safety, Semiconductors, Spectroscopy, Quantum efficiency, Polymers, Analytical research, Biology, Optical spectroscopy

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Proceedings Article | 7 November 2007 Paper

Recent advances in the development of a novel aerosol sorting and deposition system for bio-threat sensing applications

Timothy Pletcher, Joseph McGinn, David Keller, Alan Huston, Jay Eversole, Vasanthi Sivaprakasam

Proceedings Volume 6739, 673910 (2007) https://doi.org/10.1117/12.737821

KEYWORDS: Particles, Atmospheric particles, Algorithm development, Aerosols, Ultraviolet radiation, Signal processing, Near infrared, Solar concentrators, Luminescence, Crystals

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Sarnoff Corporation and the Naval Research Laboratory, through support of the U.S. Department of Homeland Security, are developing an automated, high throughput bio-aerosol physical enrichment system designed for use as part of a biological-threat protection system. The Biological Aerosol-Capture-Enrichment (BioACE) system is a bio-aerosol collection system that combines three unique technologies to create physically enriched aerosol samples that can be subsequently interrogated by any number of bio-threat detection systems for the presence of threat agents. An air-to-air concentrator uses an inertial separation technique to highly concentrate an aerosol sample presented to a dual wavelength ultra-violet laser induced fluorescence (UVLIF) optical trigger used to discriminate potential threat particles from non-threat particles conveyed in a collimated particle stream. This particle classification information is used to trigger an electrostatic deposition mechanism to deposit only those particles determined to be potential bio-threats onto a stainless steel substrate. Non-threat particles are discarded with the exiting airflow. The goal for the most recent development effort has been the integration and optimization of these technologies into a unit capable of producing highly enriched particulate samples from ambient air containing variable background aerosol loading and type. Several key technical and engineering challenges were overcome during the course of this development including a unique solution for compensating particle velocity dispersion within the airflow, development of a real-time signal acquisition and detection algorithm for determining material type on a particle by particle basis at rates greater than 2000 particles per second, and the introduction of a robust method for transferring deposited particulate into a 50ul wet sample suitable for most advanced bio-detection techniques. This paper will briefly describe the overall system architecture and then concentrate on the various component and system design tradeoffs required to optimize sample enrichment performance. A system performance model will be presented along with detailed analysis of the optical system components and electronic signal processing needed for achieving high concentration sample enrichment. Experimental methods and data obtained in the laboratory setting and from real world environments will be described and used to support the performance model of the system. Finally, a number of air sampling scenarios will be analyzed using the system performance model to determine the applicability of the BioACE system to the various concepts of operation perceived to be needed for achieving a high performance bio-threat detect-to-protect system.

Proceedings Article | 2 May 2007 Paper

Field test results and ambient aerosol measurements using dual wavelength fluorescence excitation and elastic scatter for bio-aerosols

V. Sivaprakasam, A. Huston, H. B. Lin, J. Eversole, P. Falkenstein, A. Schultz

Proceedings Volume 6554, 65540R (2007) https://doi.org/10.1117/12.719326

KEYWORDS: Atmospheric particles, Luminescence, Aerosols, Particles, Beam splitters, Scattering, Sensors, Ultraviolet radiation, Light scattering, Pulsed laser operation

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Proceedings Article | 13 October 2006 Paper

Experimental performance of a novel aerosol sorting and deposition system for bio-threat sensing applications

Timothy Pletcher, Joseph McGinn, David Keller, Alan Huston, Jay Eversole, Vasanthi Sivaprakasam

Proceedings Volume 6398, 63980A (2006) https://doi.org/10.1117/12.686677

KEYWORDS: Particles, Atmospheric particles, Aerosols, Laser systems engineering, Particle systems, Prototyping, Mirrors, Aerodynamics, Microscopes, Sensing systems

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Proceedings Article | 29 December 2004 Paper

Rapid identification of biological particles using on-the-fly fluorescent marking

Matthew Hart, Horn-Bond Lin, Jason Deich, Alan Huston, Jay Eversole, Scott Knudsen

Proceedings Volume 5617, (2004) https://doi.org/10.1117/12.578338

KEYWORDS: Atmospheric particles, Aerosols, Laser induced fluorescence, Particles, Coating, Luminescence, Molecules, Liquids, Fluorescent markers, Organisms

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Proceedings Article | 29 December 2004 Paper

Optical classification of bioaerosols using UV fluorescence and IR absorption spectroscopy

Alan Huston, Vasanthi Sivaprakasam, Cathy Scotto, Horn-Bond Lin, Jay Eversole, Abraham Schultz, Jeff Willey

Proceedings Volume 5617, (2004) https://doi.org/10.1117/12.578062

KEYWORDS: Luminescence, Atmospheric particles, Aerosols, Infrared spectroscopy, Ultraviolet radiation, Proteins, Principal component analysis, Bacteria, Particles, Absorption spectroscopy

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Proceedings Article | 16 December 2004 Paper

Multiple UV wavelength excitation and fluorescence of bioaerosols

Vasanthi Sivaprakasam, Alan Huston, Cathy Scotto, Jay Eversole

Proceedings Volume 5585, (2004) https://doi.org/10.1117/12.571296

KEYWORDS: Luminescence, Atmospheric particles, Aerosols, Ultraviolet radiation, Particles, Light scattering, Principal component analysis, Pulsed laser operation, Beam splitters, Proteins

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Proceedings Article | 1 September 1999 Paper

In vivo radiotherapy dose monitoring system

Alan Huston

Proceedings Volume 3746, 37463T (1999) https://doi.org/10.1117/12.2302127

KEYWORDS: Radiotherapy, Sensors, Scintillation, Fiber optics sensors, X-rays, Tumors, Fused quartz, Semiconductor lasers, Glasses, Tissues

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Showing 5 of 19 publications

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