Pancreatic ductal adenocarcinoma (PDAC) ranks among the malignancies with the highest fatality and morbidity rates. This is predominantly attributable to an absence of understanding the intricate and diverse microenvironment of the tumor. We use terahertz time-domain spectroscopy (THz-TDS) imaging in transmission geometry to probe ex-vivo the heterogenous microenvironment of the genetically modified murine PDAC tissue that closely resembles the PDAC heterogeneity in human malignancy. We introduced a maximum a-posteriori probability estimation algorithm to objectively the tumor’s heterogenous microenvironment using the average values of refractive index and absorption coefficient within the useable terahertz bandwidth as imaging markers. Direct comparison of stained histopathologic images and the refractive index and the absorption coefficient high-resolution, two-dimensional maps of the same PDAC samples confirms the high potential of the THz-TDS method for tumor tissue characterization.
We present a photodetector capable of detecting both optical and x-ray picosecond pulses, based on our in-house grown cadmium magnesium telluride (Cd,Mg)Te single crystals. We focused on a specific Cd0.97Mg0.03Te, In-doped crystal composition, because of its bandgap suitable for 800-nm-wavelength light detection and a single-picosecond optical photoresponse. The detector was fabricated as a planar metal-semiconductor-metal structure with interdigitated electrodes and exhibited a linear, Schottky-free, current-voltage characteristics with <40-pA dark current and up to 20-mA/W responsivity. The detector temporal resolution was measured to be ~200-ps full-width-at-half-maximum transient, in response of ~100-fs-wide pulses consisting of either optical (800-nm wavelength) or x-ray (4.5-keV) photons and was limited by the detector housing and 15-GHz bandwidth of the readout oscilloscope. The latter demonstrates the detector is suitable for coarse timing in x-ray free-electron laser/optical femtosecond pump-probe spectroscopy applications. We also demonstrated that due to its very high stopping power, the Cd0.97Mg0.03Te detector responded well to various nuclear gamma sources with energy ranging from 59.6-keV to 660-keV.
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