Spatially distributed biosensors are being developed for many healthcare applications. We have focused on such sensor arrays with the longer term goal of developing technologies for reading out and writing in information for brain circuits. In this presentation we highlight recent work where approaches to large scale cortical neural interfaces by entirely wireless means are developed, built as spatially distributed autonomous networks of wireless neural microsensors. From a systems level perspective, three key elements are critical: (i) individual sensor design and fabrication of hermetic, active electronic microdevices; (ii) implementation of high data rate wireless telecommunication methods, scalable for thousands of sensors; (iii) high performance computing platforms to decode and encode large amounts of physiological data for real-time analysis.
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