Dr. Giancarol Morelli Profile

Dr. Giancarol Morelli

at Univ. degli Studi di Napoli Federico II

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 1 April 2020 Presentation + Paper

Fluorescence waveguiding in amyloidogenic fibers

Boris Apter, Boris Fainberg, Amir Handelman, Igor Lapsker, Antonella Accardo, Carlo Diaferia, Giancarlo Morelli, Gil Rosenman

Proceedings Volume 11360, 113600D (2020) https://doi.org/10.1117/12.2554948

KEYWORDS: Optical fibers, Light wave propagation, Waveguides, Absorption, Photons, Biomedical optics, Polymers, Radio propagation, Laser beam propagation, Geometrical optics

Read Abstract +

Chemically synthesized biomolecules can self-assemble to bioinspired nanostructures of different morphologies such as dots, tubes, spheres, nanofibers and more. They adopt similar basic ordering as their biological counterparts either α-helical or β-sheet peptide/protein conformations. These two fundamental biomolecular architectures exhibit dissimilar physical properties. One of the most interesting physical properties found in biological and bioinspired structures is a new biophotonic phenomenon of visible fluorescence (FL). It has been observed both in neurodegenerative disease-related amyloid fibrils and in synthetic amyloidogenic biorganic di- and tri-aromatic and aliphatic peptide nanostructures. The FL effect has been also found recently in peptide nanodots and hybrid polymer/peptide thin films. All of them have been assembled to β-sheet secondary structure. In this work we report on a new development of FL optical waveguiding in elongated bioinspired fibrillary structures, self-assembled from ultrashort amylodogenic peptides/proteins and hybrid polymer/peptides biomolecules. We show that FL propagation in these two fiber materials of different origin can be described by two completely different mechanisms. One of them is conventional FL propagation in the region of optical transparency of peptide materials in accordance with optical confinement rules. Another model is FL reabsorption mechanism where anomalous long range FL propagation has been found. We show that this intrinsic FL biophotonic waveguiding effects found in different β- sheet biomaterials is considered as a promising tool for precise biomedicine where new biocompatible visible tunable FL optical waveguides can be applied in advanced nanomedical technologies (local bioimaging, light diagnostics, therapy, optogenetitcs and health monitoring).

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years