Recent advances in inkjet-printed optics have created a new class of lens fabrication technique. Dubbed DotLens, a single of which weighs less than 50 mg and occupies a volume less than 50 μL. DotLens can be attached onto any smartphone camera akin to a contact lens, and turn the smartphones into a microscope. In this paper, we show recent results from images collected from a variety of biological samples. Lately, we have demonstrated that by data analytics the smartphone microscope is capable of detect nanoscale objects and their minute color changes, called nanocolorimetry. We have applied it to the detection and quantification of lean ion in drinking water with performance surpassing the EPA standard.
Compared to traditional optical fibers, which are designed to transmit light from one end to the other, a multi-point side firing optical fiber can be useful in several applications such as phototherapy, optogenetics brain stimulation and remote sensing. We present the fabrication and characterization of an optical fiber capable of launching light from virtually any point along its circumferential surface by laser micro-ablation. Continuous wave (CW) laser radiation was employed to form a conical-shaped cavity (side window) in the fiber core. Because of the total internal reflection, when the laser beam reached the side window-outside medium interface, the beam was reflected to the side of the optical fiber. A single side window on 730 μm fiber can deliver more than 8% of the total coupled light. Light-firing output can be increased to more than 19% by using femtosecond (fs) laser ablation on smaller optical fiber (65 µm). In addition, the fiber also exhibited 3-dimensional light emission by placing side-windows of various orientations on its axis.
We envision the 65 um-OD multi-point side-firing optical fiber to be employed in optogenetics brain neuron stimulation in vivo. To test the feasibility of this approach, ablated fibers were investigated in agar-based tissue mimicking material (0.5% w/v in water). Successful multi-point side-firing capability has been demonstrated in the tissue phantom with similar refractive index. Furthermore, this experiment was also used to test the side-firing fiber’s mechanical strength in order to optimize the window’s depth.
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