KEYWORDS: Ultrasonography, Photoacoustic imaging, Microscopy, Data acquisition, Photoacoustic spectroscopy, In vivo imaging, Algorithm development, Temporal resolution, Super resolution, Oncology
Photoacoustic (PA) imaging can map the physiological conditions of tissue and track the biodistribution of contrast agents; ultrasound localization microscopy (ULM) with microbubbles provides deep-tissue super-resolution blood vessel images and blood velocity maps. When combined, the dual imaging technique will become a powerful tool with diverse applications. However, longer acquisition time of ULM poses a challenge. To address this, we propose sparsity constraint optimization to accelerate ULM and develop an interleaved PA/fast ULM imaging sequences for the dual imaging. We demonstrate 3D and time-lapse dual imaging with a commonly used linear array imaging system in a mouse model.
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