Dr. Kecan Lin Profile

Dr. Kecan Lin

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Proceedings Article | 9 October 2021 Presentation + Paper

Preliminary study of surface-enhanced Raman spectroscopy (SERS) of serum samples of liver cancer patients

Qiwen Wang, Mengmeng Zheng, Yuhong Fang, Kecan Lin, Shusen Xie, Zheng Huang

Proceedings Volume 11900, 119000U (2021) https://doi.org/10.1117/12.2602627

KEYWORDS: Liver cancer, Surface enhanced Raman spectroscopy, Blood, Cancer, Silver, Raman spectroscopy, Proteins, Molecules, Liver

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Background: Liver cancer is a leading cause of cancer mortality in China. Early diagnosis and treatment play a significant role in reducing liver cancer mortality. Aims: In this preliminary study, the feasibility of using surface enhanced Raman spectroscopy (SERS) of serum to identify primary liver cancer was explored. Materials and methods: Serum samples were obtained from liver cancer patients (n = 25) and healthy controls (n = 30). Nano-silver (Ag) colloids (45 ± 6 nm) were used as the SERS substrate and mixed with serum samples (10 μL). Raman spectra were obtained from a confocal Raman micro-spectrometer (Renishaw) and spectral characteristics analyzed. Results: Analyses of spectral characteristics showed noticeable differences in peak heights between the mean spectra of the control and patients, mainly reflected in following peak positions: increased at 496, 593, 637, 726, 813, 888, and 1137 cm^-1, and decreased at 1580 cm^-1, respectively. Which might be attributable to glycogen, phosphatidylinositol, aminoacid methionine, C-S (protein), C-C stretching, methylene rocking, palmitic acid and C-C stretching, respectively. Conclusion: These preliminary analyses suggest that SERS might be useful for the identification of serum markers of liver cancer.

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