Dr. Kuang-Li Lee Profile

Dr. Kuang-Li Lee

Associate Research Scholar at Academia Sinica

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 10 May 2019 Paper

96-well capped gold nanoslits for backside-reflection plasmonic biosensing

Kuang-Li Lee, Po-Cheng Tsai, Meng-Lin You, Pei-Kuen Wei

Proceedings Volume 11007, 1100704 (2019) https://doi.org/10.1117/12.2518423

KEYWORDS: Gold, Reflection, Nanostructures, Refractive index, Plasmonics, Biosensing, Proteins, Interfaces, Water, Sensors

Read Abstract +

A nanostructure-based plasmonic biochip with the same size as standard 96-well plates for backside reflection-type biosensing was proposed and validated through analyses of biological interactions. The capped gold nanoslit arrays were fabricated on a polycarbonate plastic film using a rapid hot embossing nanoimprint lithography process. The optical properties of capped gold nanoslits with different structure parameters in backside reflection geometry were studied; their refractive index (bulk) and surface (thickness) sensitivities were verified. By changing the cavity length, the coupling between a broadband cavity resonance and a narrowband surface plasmon resonance mode results in an asymmetric Fano resonance in the reflection spectra. The coupling mode is able to enhance the thickness sensitivity by a factor of 2.4 with wavelength interrogation. The bulk and thickness sensitivities were 454 nm/RIU and 1.14 nm/nm, respectively. The protein-protein interaction experiments verified the sensing capabilities and high sensitivity of the capped nanostructures; a limit of detection (LOD) of 2 ng/mL IgA was achieved. Such a multi-well plate with backside reflection-type geometry, decoupling the optical paths, allows for sensing with opaque, bubbly or highly scattering liquids and benefits multiple sensing applications in the biotechnology and agricultural products.

Proceedings Article | 3 May 2017 Presentation + Paper

Fano resonances in capped metallic nanostructures for highly sensitive plasmonic sensors

Kuang-Li Lee, Pei-Kuen Wei

Proceedings Volume 10215, 102150E (2017) https://doi.org/10.1117/12.2267758

KEYWORDS: Aluminum, Metals, Refractive index, Water, Surface plasmons, Dielectrics, Plasmonic sensors, Oxides, Nanostructures, Sensors, Plasmons, Optical biosensors

Read Abstract +

Nanostructure-based surface plasmon resonance (SPR) sensors are capable of sensitive, real-time, label-free, and multiplexed detection for chemical and biomedical applications. Recently, the studies of nanostructure-based aluminum sensors have attracted a large attention. However, the intrinsic properties of aluminum metal, having a large imaginary part of the dielectric function and a longer electromagnetic field decay length, limit nanostructure’s surface sensing capability. To improve the surface sensitivity, a nearly guided wave SPR sensor has been proposed, which enables the surface plasmons to spread along the dielectric layer and increases the interaction volume. Here we proposed the combination between Fano resonances in capped nanoslits and a thin nanodielectric top layer to develop highly sensitive nanostructure-based aluminum sensors. We studied the effects of an Al₂O₃ protection layer on the optical properties, bulk and surface (wavelength and intensity) sensitivities of capped aluminum nanoslits. We found the top layer can enhance the sensitivities of the Wood’s anomaly-dominant resonance or asymmetric Fano resonance in capped aluminum nanoslits. The maximum improvement can be reached by a factor of 16. The maximum wavelength and intensity sensitivities are 6.8 nm/nm and 150 %/nm, respectively. With 1.71 % intensity change (3 times of noise level), the limit of detection of Al₂O₃ film thickness was 0.018 nm. We attributed the enhanced surface sensitivity for capped aluminum nanoslits to a reduced evanescent length and sharp slope of the asymmetric profile caused by the capped oxide layer and Fano coupling. The protein-protein interaction experiments verified the high sensitivity of the Al₂O₃-aliminum capped nanoslits.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years