Dr. Logan Hubbard Profile

Dr. Logan Hubbard

at Univ. of California, Irvine

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

SPIE Journal Paper | 31 October 2023

Low-dose quantitative CT myocardial flow measurement using a single volume scan: phantom and animal validation

Logan Hubbard, Sabee Molloi

JMI, Vol. 10, Issue 05, 056002, (October 2023) https://doi.org/10.1117/12.10.1117/1.JMI.10.5.056002

KEYWORDS: Computed tomography, Animals, Tissues, Microspheres, Blood, Attenuation, Animal model studies, Data modeling, Myocardium, Arteries

Read Abstract +

PurposeTo validate a low-dose, single-volume quantitative CT myocardial flow technique in a cardiovascular flow phantom and a swine animal model of coronary artery disease.ApproachA cardiovascular flow phantom was imaged dynamically over different flow rates (0.97 to 2.45 mL / min / g) using 15 mL of contrast per injection. Six swine (37 ± 8 kg) were also imaged dynamically, with different left anterior descending coronary artery balloon stenoses assessed under intracoronary adenosine stress, using 1 mL / kg of contrast per injection. The resulting images were used to simulate dynamic bolus tracking and peak volume scan acquisition. After which, first-pass single-compartment modeling was performed to derive quantitative flow, where the pre-contrast myocardial attenuation was assumed to be spatially uniform. The accuracy of CT flow was then assessed versus ultrasound and microsphere flow in the phantom and animal models, respectively, using regression analysis.ResultsSingle-volume quantitative CT flow measurements in the phantom (QCT_PHANTOM) were related to reference ultrasound flow measurements (QUS) by QCT_PHANTOM = 1.04 QUS − 0.1 (Pearson’s r = 0.98; RMSE = 0.09 mL / min / g). In the animal model (QCT_ANIMAL), they were related to reference microsphere flow measurements (QMICRO) by QCT_ANIMAL = 1.00 QMICRO − 0.05 (Pearson’s r = 0.96; RMSE = 0.48 mL / min / g). The effective dose per CT measurement was 1.21 mSv.ConclusionsThe single-volume quantitative CT flow technique only requires bolus tracking data, spatially uniform pre-contrast myocardial attenuation, and a single volume scan acquired near the peak aortic enhancement for accurate, low-dose, myocardial flow measurement (in mL/min/g) under rest and adenosine stress conditions.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years