Sex-related skin differences are known to be expressed such as differences in sebum secretion, yet the relationship to skin’s internal structures is still unclear. Recently, a histopathological study revealed differences in micro-vessel density between females and males. Past studies have been limited to histological vascular assessments, but this study aimed to characterize dermal blood vessels in females and males using optical coherence tomography angiography. We found sex-related differences in vessel volume density through inflammatory-related factors. Also, a male group with higher vascular density showed higher trans-epidermal water loss, implying a relationship between dermal vasculature and skin physiological conditions in males.
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