Bioproduction is becoming increasingly important for the pharmaceutical industry. Real-time impurities monitoring during the purification phase could increase productivity and reduce drug cost. Here, we present a silicon photonics platform based on biofunctionalized Mach Zehnder Interferometers for this application. We demonstrate host cell proteins detection in the μg/ml range within 1 min, as well as the possibility to serially monitor up to 8 samples using a single silicon die.
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