Dr. Maria Klimova Profile

Dr. Maria Klimova

at Saratov State Univ

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Publications (8)

Proceedings Article | 9 April 2020 Paper

Conjugation of Zn (II) phthalocyanine with polymeric brushes for improved photodiagnostics and photodynamic therapy of gastric tumours

E. Borisova, Ts. Genova, A. Yakimansky, V. Mantareva, I. Angelov, A. Gisbrecht, Al. Khorovodov, I. Agranovich, M. Klimova, O. Semyachkina-Glushkovskaya

Proceedings Volume 11457, 114570R (2020) https://doi.org/10.1117/12.2559938

KEYWORDS: Polymers, Photodynamic therapy, Luminescence, Molecules, In vivo imaging, Cancer, Fluorescence spectroscopy, Tissues

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The target-specific drug release which is depending on the pH of the medium appears precious approach for increasing of drug selectivity and further efficacy in photodynamic diagnosis (PDD) and therapy (PDT) of cancer. A strongly hydrophobic Zn (II) phthalocyanine (ZnPc) along with its liposomal formulates belongs to the clinically approved phthalocyanines for cancer photodiagnosis PDD and PDT. Nevertheless closed to the ideal photo-physicochemical properties the planar molecular structure of ZnPc easily forms aggregates which finally limit the phototoxic effect. Different strategies are on hand, all aiming to minimize the formation of photo-inactive associates. At present time, the polymeric carrier systems are still under development as carrier systems for biomedical applications. The present work evaluated the efficiency of two recently proposed graft - copolymers namely polyimide (PI)-graft-polymethacrylic acid (PAT2 and PAT3) as vehicles of hydrophobic ZnPc. The potential of the proposed polymeric brushes with great number of carboxylic groups, for conformational changes in different pH media, can be used for ZnPc release as studied by fluorescence spectroscopy. Complexes developed were investigated in vivo on rat model system of gastric carcinoma lesions for photodiagnosis and photodynamic treatment of neoplasia and compared with the application of ZnPcs solely. The contrast achieved of the fluorescence detection using polymer brushes - phthalocyanine conjugate is about twice higher that standard applied photosensitizer using same protocol and doses of application. The photodynamic treatment efficacy was also significantly improved allowing to receive full response using doses of 0,5-1 mg/kg of the conjugates. |To obtain same efficiency for the ZnPc PDT in the gastric lesions treated drug doses of 1,5-2 mg/kg had to be applied. Initially detected fluorescence signal and photo-bleaching dynamics were used for the monitoring of the processes of accumulation and photodynamic treatment processes.

Proceedings Article | 6 March 2020 Presentation

Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer’s disease (Conference Presentation)

Oxana Semyachkina-Glushkovskaya, Ekaterina Zinchenko, Maria Klimova, Andrey Terskov, Arkady Abdurashitov, Alexander Dubrovsky, Inna Blokhina, Alexander Khorovodov, Ilana Agranovich, Nikita Navolokin, Alexander Shirokov, Elena Saranceva, Aysel Mamedova, Valery Tuchin, Juergen Kurths

Proceedings Volume 11241, 1124103 (2020) https://doi.org/10.1117/12.2541561

KEYWORDS: Brain, Alzheimer's disease, Lymphatic system, Optical coherence tomography, Confocal microscopy, Gold, Nanorods, Neck

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Proceedings Article | 3 June 2019 Paper

The role of the meningeal lymphatic in the brain clearing

M. Klimova , A. Dubrovsky, E. Duarte Torres , A. Abdurashitov, A. Shirokov, A. Terskov, A. Khorovodov, E. Sarantseva, T. Iskra, O. Semyachkina-Glushkovskaya

Proceedings Volume 11067, 110670Z (2019) https://doi.org/10.1117/12.2524451

KEYWORDS: Lymphatic system, Brain, Blood brain barrier, Optical coherence tomography, Confocal microscopy, In vivo imaging, Tissues, Nanorods, Tomography, Neuroimaging

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Proceedings Article | 3 June 2019 Paper

Diagnostic of gastric pre-cancer with complexity analysis

Alexey Pavlov, Ekaterina Borisova, Olga Pavlova, Ilana Agranovich, Alexander Khorovodov, Andrey Terskov, Aysel Mamedova, Maria Klimova, Oxana Semyachkina-Glushkovskaya

Proceedings Volume 11067, 110670K (2019) https://doi.org/10.1117/12.2522421

KEYWORDS: Cancer, Diagnostics, Tumors, Animal model studies, Stomach, Data processing

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Proceedings Article | 3 June 2019 Paper

Lymphatic or glymphatic systems: opposite conceptions in fundamental understanding of the brain clearing

M. Klimova, E. Duarte Torres , E. Saranceva, T. Chukalina, T. Iskra, O. Semyachkina-Glushkovskaya, Ju. Kurths

Proceedings Volume 11067, 110670G (2019) https://doi.org/10.1117/12.2524687

KEYWORDS: Lymphatic system, Brain, Space reconnaissance, Arteries, Visualization, Tissues, Veins, Blood brain barrier, Medicine, Neurophysiology

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Proceedings Article | 4 March 2019 Presentation + Paper

Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance

O. Semyachkina-Glushkovskaya, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Terskov, A. Mamedova, A. E. Shareef, E. Saranceva, T. Iskra, A. Pavlov, J. Kurths

Proceedings Volume 10879, 108790C (2019) https://doi.org/10.1117/12.2508259

KEYWORDS: Brain, Blood brain barrier, Laser therapeutics, Receptors, Tissues

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Proceedings Article | 1 March 2019 Presentation + Paper

Lymphatic clearance from the blood after subarachnoid hemorrhages

O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Dubrovsky, A. Shirokov, N. Navolokin, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Mamedova, A. E. Shareef, A. Terskov, E. Saranceva, T. Iskra, J. Kurths

Proceedings Volume 10865, 108650T (2019) https://doi.org/10.1117/12.2509065

KEYWORDS: Lymphatic system, Blood, Brain, Optical coherence tomography, Blood brain barrier, Statistical analysis, Absorption spectroscopy, Tomography

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Proceedings Article | 26 April 2018 Paper

Optical coherent tomography and fluorescent microscopy for the study of meningeal lymphatic systems

O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Namykin, I. Fedosov, A. Pavlov, A. Karavaev, O. Sindeeva, A. Shirokov, M. Ulanova, N. Shushunova, A. Khorovodov, I. Agranovich, A. Bodrova, M. Sagatova, Ali Esmat Shareef, E. Saranceva, M. Dvoryatkina, V. Tuchin

Proceedings Volume 10717, 107171Y (2018) https://doi.org/10.1117/12.2315200

KEYWORDS: Lymphatic system, Microscopy, Optical coherence tomography, Brain, Imaging systems, Tomography, In vivo imaging, Blood vessels

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Showing 5 of 8 publications

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