Dr. Naomi Yu Ko Profile

Dr. Naomi Yu Ko

at Boston Medical Ctr

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Author

Publications (4)

Proceedings Article | 7 March 2022 Presentation

Paced breathing hemodynamics in healthy and cancerous breast tissue measured with a high-optode density wearable diffuse optical probe

Samuel Spink, Adam Eggebrecht, Naomi Ko, Darren Roblyer

Proceedings Volume PC11956, PC1195605 (2022) https://doi.org/10.1117/12.2607388

KEYWORDS: Tissue optics, Hemodynamics, Breast, Tumors, Tomography, Tissues, Spatial resolution, Sensors, Optical components, Oncology

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SPIE Journal Paper | 2 June 2021 Open Access

High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue

Samuel Spink, Fei Teng, Vivian Pera, Hannah Peterson, Tim Cormier, Alexis Sauer-Budge, David Chargin, Sam Brookfield, Adam Eggebrecht, Naomi Yu Ko, Darren Roblyer

JBO, Vol. 26, Issue 06, 062708, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.062708

KEYWORDS: Breast, Tissue optics, Hemodynamics, Tissues, Sensors, Tumors, Optical properties, Near infrared spectroscopy, Absorption, In vivo imaging

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Significance: Diffuse optical imaging (DOI) provides in vivo quantification of tissue chromophores such as oxy- and deoxyhemoglobin (HbO2 and HHb, respectively). These parameters have been shown to be useful for predicting neoadjuvant treatment response in breast cancer patients. However, most DOI devices designed for the breast are nonportable, making frequent longitudinal monitoring during treatment a challenge. Furthermore, hemodynamics related to the respiratory cycle are currently unexplored in the breast and may have prognostic value. Aim: To design, fabricate, and validate a high optode-density wearable continuous wave diffuse optical probe for the monitoring of breathing hemodynamics in breast tissue. Approach: The probe has a rigid-flex design with 16 dual-wavelength sources and 16 detectors. Performance was characterized on tissue-simulating phantoms, and validation was performed through flow phantom and cuff occlusion measurements. The breasts of N = 4 healthy volunteers were measured while performing a breathing protocol. Results: The probe has 512 unique source–detector (S-D) pairs that span S-D separations of 10 to 54 mm. It exhibited good performance characteristics: μa drift of 0.34%/h, μa precision of 0.063%, and mean SNR ≥ 24 dB up to 41 mm S-D separation. Absorption contrast was detected in flow phantoms at depths exceeding 28 mm. A cuff occlusion measurement confirmed the ability of the probe to track expected hemodynamics in vivo. Breast measurements on healthy volunteers during paced breathing revealed median signal-to-motion artifact ratios ranging from 8.1 to 8.7 dB. Median ΔHbO2 and ΔHHb amplitudes ranged from 0.39 to 0.67 μM and 0.08 to 0.12 μM, respectively. Median oxygen saturations at the respiratory rate ranged from 82% to 87%. Conclusions: A wearable diffuse optical probe has been designed and fabricated for the measurement of breast tissue hemodynamics. This device is capable of quantifying breathing-related hemodynamics in healthy breast tissue.

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Proceedings Article | 5 March 2021 Presentation

Paced breathing hemodynamics in breast tumors measured with a high-optode density wearable diffuse optical probe

Samuel Spink, Adam Eggebrecht, Naomi Ko, Darren Roblyer

Proceedings Volume 11622, 116220L (2021) https://doi.org/10.1117/12.2577266

KEYWORDS: Hemodynamics, Tumors, Breast, Synthetic aperture radar, Sensors, Optical components, Oncology, Light emitting diodes, Continuous wave operation, Cancer

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SPIE Journal Paper | 13 January 2017 Open Access

Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions

Fei Teng, Timothy Cormier, Alexis Sauer-Budge, Rachita Chaudhury, Vivian Pera, Raeef Istfan, David Chargin, Samuel Brookfield, Naomi Yu Ko, Darren Roblyer

JBO, Vol. 22, Issue 01, 014001, (January 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.1.014001

KEYWORDS: Tissue optics, Breast, Sensors, Breast cancer, Hemodynamics, Light emitting diodes, Tissues, Biomedical optics, Oxygen, Signal to noise ratio

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