Prof. Robert M. Hoffman Profile

Prof. Robert M. Hoffman

at AntiCancer Inc

SPIE Involvement:

Author

Publications (29)

Proceedings Article | 17 March 2023 Presentation

Fluorescence conjugated anti-mucin antibodies to target and brightly label colorectal and pancreatic cancer

Kristin Cox, Michael Turner, Siamak Amirfakhri, Thinzar Lwin, Shanglei Liu, Robert Hoffman, Surinder Batra, Michael Bouvet

Proceedings Volume PC12361, PC123610I (2023) https://doi.org/10.1117/12.2650520

KEYWORDS: Pancreatic cancer, Luminescence, Colorectal cancer, Tumors, Mouse models, Cancer, Near infrared, Imaging systems, Colon, Visualization

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Proceedings Article | 4 March 2022 Presentation + Paper

Precise tumor targeting and labeling with a flourescent mucin 4 antibody for imaging patient-derived pancreatic cancer in a mouse model

Michael Turner, Hiroto Nishino, Siamak Amirfakhri, Sukhwinder Kaur, Kavita Mallya, Robert Hoffman, Surinder Batra, Michael Bouvet

Proceedings Volume 11943, 1194305 (2022) https://doi.org/10.1117/12.2610524

KEYWORDS: Tumors, Pancreatic cancer, Surgery, Mouse models, Luminescence, Visualization, Medicine

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Proceedings Article | 4 March 2022 Presentation + Paper

Color-coded labeling of colon cancer liver metastasis and adjacent liver segment for image guided metastasectomy: a proof of concept review of clinical translatability

Hiroto Nishino, Michael Turner, Siamak Amirfakhri, Hannah Hollandsworth, Thinzar Lwin, Jun Yamamoto, Bérénice Framery, Françoise Cailler, Bernhard Singer, Robert Hoffman, Michael Bouvet

Proceedings Volume 11943, 1194306 (2022) https://doi.org/10.1117/12.2610557

KEYWORDS: Liver, Image segmentation, Tumors, Luminescence, Surgery, Visualization, Mouse models, Veins, Multichannel imaging systems, Indocyanine green

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SPIE Journal Paper | 28 June 2019 Open Access

Improved antibody-guided surgery with a near-infrared dye on a PEGylated linker for CEA-positive tumors

Paul Yazaki, Thinzar Lwin, Megan Minnix, Lin Li, Anakim Sherman, Justin Molnar, Aaron Miller, Paul Frankel, Junie Chea, Erasmus Poku, Nicole Bowles, Robert Hoffman, John Shively, Michael Bouvet

JBO, Vol. 24, Issue 06, 066012, (June 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.6.066012

KEYWORDS: Tumors, Surgery, Near infrared, Pancreatic cancer, Blood, Cancer, Luminescence, Tissues, Magnesium, In vivo imaging

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Proceedings Article | 7 March 2019 Presentation + Paper

Development of a humanized anti-CEA antibody for fluorescent guided surgery of GI cancers

Paul Yazaki, Thinzar Lwin, Megan Minnix , Lin Li, Anakim Sherman, Justin Molnar, Aaron Miller, Junie Chea, Erasmus Poku, Nicole Bowles, Robert Hoffman, John Shively, Michael Bouvet

Proceedings Volume 10862, 108620N (2019) https://doi.org/10.1117/12.2511771

KEYWORDS: Tumors, Surgery, Near infrared, Pancreatic cancer, Blood, Cancer, Tissues, In vivo imaging, Magnesium, Luminescence

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Proceedings Article | 1 March 2018 Presentation + Paper

Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

Thinzar Lwin, Kentaro Miyake, Takashi Murakami, Jonathan DeLong, Paul Yazaki, John Shivley, Bryan Clary, Robert Hoffman, Michael Bouvet

Proceedings Volume 10478, 104780O (2018) https://doi.org/10.1117/12.2292546

KEYWORDS: Pancreatic cancer, Near infrared, Tumor growth modeling, In vivo imaging, Surgery

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Proceedings Article | 4 March 2016 Presentation + Paper

Fluorophore-conjugated antibodies for imaging and resection of GI tumors

Michael Bouvet, Robert Hoffman

Proceedings Volume 9696, 96960O (2016) https://doi.org/10.1117/12.2208811

KEYWORDS: Cancer, Surgery, Mouse models, Visualization, Luminescence, Signal detection, In vivo imaging, Pancreatic cancer, Colorectal cancer, Monoclonal antibodies, Tumors, Tissues, In vitro testing

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SPIE Journal Paper | 2 June 2014 Open Access

Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer

Ali Maawy, Yukihiko Hiroshima, Yong Zhang, George Luiken, Robert Hoffman, Michael Bouvet

JBO, Vol. 19, Issue 10, 101504, (June 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.10.101504

KEYWORDS: Tumors, Near infrared, Pancreatic cancer, Liver, Mouse models, Lung, Tissues, Lymphatic system, Cancer, Surgery

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SPIE Journal Paper | 19 December 2013 Open Access

Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models

Ali Maawy, Yukihiko Hiroshima, Sharmeela Kaushal, George Luiken, Robert Hoffman, Michael Bouvet

JBO, Vol. 18, Issue 12, 126016, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.126016

KEYWORDS: Tumors, Luminescence, Pancreatic cancer, Tissues, Mouse models, Imaging systems, Cancer, Tumor growth modeling, Skin, Liver

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Proceedings Article | 15 February 2012 Paper

Watching stem cells at work with a flexible multiphoton tomograph

Aisada Uchugonova, Robert Hoffmann, Martin Weinigel, Karsten König

Proceedings Volume 8226, 82260V (2012) https://doi.org/10.1117/12.908027

KEYWORDS: Stem cells, Skin, Tissue optics, In vivo imaging, Second-harmonic generation, Image resolution, Green fluorescent protein, Multiphoton tomography, Collagen, Wound healing

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SPIE Journal Paper | 1 November 2010 Open Access

Long-working-distance fluorescence microscope with high-numerical-aperture objectives for variable-magnification imaging in live mice from macro- to subcellular

Hiroaki Kimura, Masashi Momiyama, Katsuro Tomita, Hiroyuki Tsuchiya, Robert Hoffman

JBO, Vol. 15, Issue 06, 066029, (November 2010) https://doi.org/10.1117/12.10.1117/1.3526356

KEYWORDS: Cancer, Lung, Luminescence, Microscopes, In vivo imaging, Visualization, Green fluorescent protein, Skin, Veins, Fluorescent proteins

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SPIE Journal Paper | 1 November 2010 Open Access

Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

Ahmet Erten, David Hall, Carl Hoh, Hop Tran Cao, Sharmeela Kaushal, Sadik Esener, Robert Hoffman, Michael Bouvet, James Chen, Santosh Kesari, Milan Makale

JBO, Vol. 15, Issue 06, 066012, (November 2010) https://doi.org/10.1117/12.10.1117/1.3509111

KEYWORDS: Tumors, Magnetic resonance imaging, Luminescence, Cancer, Tissues, Neodymium, Resonance enhancement, Health sciences, Lanthanum, Fluorescence spectroscopy

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SPIE Journal Paper | 1 March 2009 Open Access

Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue

Milan Makale, Michele McElroy, Peter O'Brien, Robert Hoffman, Sharon Guo, Michael Bouvet, Leo Barnes, Elizabeth Ingulli, David Cheresh

JBO, Vol. 14, Issue 02, 024032, (March 2009) https://doi.org/10.1117/12.10.1117/1.3103783

KEYWORDS: Microscopes, Imaging systems, Tumors, Objectives, Confocal microscopy, Lymphatic system, Tissues, Lenses, Sensors, Pancreas

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Proceedings Article | 29 February 2008 Paper

Imaging enhancement of malignancy by cyclophosphamide: surprising chemotherapy opposite effects

Kensuke Yamauchi, Meng Yang, Katsuhiro Hayashi, Ping Jiang, Mingxu Xu, Norio Yamamoto, Hiroyuki Tsuchiya, Katsuro Tomita, A. Moossa, Michael Bouvet, Robert Hoffman

Proceedings Volume 6868, 68680I (2008) https://doi.org/10.1117/12.772085

KEYWORDS: Cancer, Veins, Tumors, Liver, Lung, Colorectal cancer, In vivo imaging, Visualization, Green fluorescent protein, Liver cancer

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Proceedings Article | 29 February 2008 Paper

Specific in vivo labeling with GFP retroviruses, lentiviruses, and adenoviruses for imaging

Robert Hoffman, Hiroyuki Kishimoto, Toshiyoshi Fujiwara

Proceedings Volume 6868, 68680F (2008) https://doi.org/10.1117/12.773308

KEYWORDS: Green fluorescent protein, Tumors, In vivo imaging, Liver, Luminescence, Fluorescent proteins, Cancer, Visualization, Lymphatic system, Packaging

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Proceedings Article | 13 February 2008 Paper

Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants

Robert Hoffman, Katsuhiro Hayashi, Ming Zhao

Proceedings Volume 6868, 68680K (2008) https://doi.org/10.1117/12.772067

KEYWORDS: Tumors, Bacteria, Green fluorescent protein, Tissues, Prostate, Cancer, Mouse models, Lung, Breast, Control systems

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Proceedings Article | 13 February 2008 Paper

Use of GFP for in vivo imaging: concepts and misconceptions

Robert Hoffman

Proceedings Volume 6868, 68680E (2008) https://doi.org/10.1117/12.774181

KEYWORDS: Green fluorescent protein, Tumors, Fluorescent proteins, In vivo imaging, Cancer, Proteins, Tissues, Luminescence, Skin, Imaging systems

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Proceedings Article | 13 February 2008 Paper

Noninvasive imaging in vivo with fluorescent proteins from centimeters to micrometers

Meng Yang, Ping Jiang, Manal Al-Zaid, Robert Hoffman

Proceedings Volume 6868, 68680G (2008) https://doi.org/10.1117/12.772122

KEYWORDS: Tumors, Cancer, Green fluorescent protein, Fluorescent proteins, In vivo imaging, Whole body imaging, Proteins, Tissues, Tumor growth modeling, Microscopes

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Proceedings Article | 13 February 2008 Paper

Subcellular real-time in vivo imaging of intralymphatic and intravascular cancer-cell trafficking

M. McElroy, K. Hayashi, S. Kaushal, M. Bouvet, Robert Hoffman

Proceedings Volume 6868, 68680J (2008) https://doi.org/10.1117/12.772120

KEYWORDS: Cancer, Lymphatic system, Skin, Imaging systems, Tumors, Real time imaging, Green fluorescent protein, Blood vessels, Skin cancer, In vivo imaging

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Proceedings Article | 14 February 2007 Paper

Preclinical fluorescent mouse models of pancreatic cancer

Michael Bouvet, Robert Hoffman

Proceedings Volume 6449, 64490X (2007) https://doi.org/10.1117/12.708060

KEYWORDS: Tumors, Pancreatic cancer, Tumor growth modeling, Visualization, Liver, Green fluorescent protein, Luminescence, Pancreas, Blood vessels, In vivo imaging

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Proceedings Article | 3 February 2007 Paper

Whole-body subcellular multicolor imaging

Meng Yang, Ping Jiang, Robert Hoffman

Proceedings Volume 6449, 64490V (2007) https://doi.org/10.1117/12.714035

KEYWORDS: Cancer, Tumors, Green fluorescent protein, In vivo imaging, Microscopes, Capillaries, Liver, Imaging systems, Veins, Laser scanners

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Proceedings Article | 23 February 2006 Paper

Multicolor fluorescence imaging of subcellular dynamics of cancer cells in live mice

Robert Hoffman

Proceedings Volume 6098, 60980D (2006) https://doi.org/10.1117/12.644923

KEYWORDS: Cancer, Veins, Capillaries, Visualization, Skin, Green fluorescent protein, Liver, Luminescence, Arteries, In vivo imaging

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SPIE Journal Paper | 1 July 2005 Open Access

Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging

Robert Hoffman

JBO, Vol. 10, Issue 04, 041202, (July 2005) https://doi.org/10.1117/12.10.1117/1.1992485

KEYWORDS: Tumors, Green fluorescent protein, Fluorescent proteins, Visualization, In vivo imaging, Luminescence, Cancer, Proteins, Whole body imaging, Blood vessels

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Proceedings Article | 4 April 2005 Paper

Study of action of cyclophosphamide and extract of mycelium of Pleurotus ostreatus in vivo on mice, bearing melanoma B16-F0-GFP

Irina Meerovich, Meng Yang, Ping Jiang, Robert Hoffman, Valery Gerasimenya, Alexander Orlov, Alexander Savitsky, Vladimir Popov

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.592546

KEYWORDS: Tumors, Melanoma, Blood, In vivo imaging, Green fluorescent protein, Proteins, Organisms, Luminescence, Visualization, Tumor growth modeling

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Proceedings Article | 4 April 2005 Paper

Imaging cellular dynamics in vivo with multicolor fluorescent proteins

Robert Hoffman

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.585093

KEYWORDS: Tumors, Green fluorescent protein, Visualization, In vivo imaging, Luminescence, Cancer, Lung, Fluorescent proteins, Blood vessels, Skin

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Proceedings Article | 14 June 2004 Paper

Dual-color fluorescence imaging of tumor/host interaction with green and red fluorescent proteins

Meng Yang, Yasuyuki Amoh, Lingna Li, Eugene Baranov, Jin Wei Wang, Ping Jiang, A.R. Moossa, Robert Hoffman

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.528023

KEYWORDS: Tumors, Green fluorescent protein, Tissues, Luminescence, Visualization, Microscopy, Melanoma, Blood vessels, Fluorescent proteins, Whole body imaging

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Proceedings Article | 28 May 2002 Paper

Fluorescence imaging of angiogenesis in green fluorescent protein-expressing tumors

Meng Yang, Eugene Baranov, Ping Jiang, Xiao-Ming Li, Jin Wang, Lingna Li, Shigeo Yagi, A. Moossa, Robert Hoffman

Proceedings Volume 4622, (2002) https://doi.org/10.1117/12.468331

KEYWORDS: Tumors, Green fluorescent protein, Luminescence, Blood vessels, Tumor growth modeling, In vivo imaging, Visualization, Lung, Cancer, Animal model studies

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Proceedings Article | 27 April 2000 Paper

External optical imaging of freely moving mice with green fluorescent protein-expressing metastatic tumors

Meng Yang, Eugene Baranov, Hiroshi Shimada, A. Moossa, Robert Hoffman

Proceedings Volume 3921, (2000) https://doi.org/10.1117/12.384220

KEYWORDS: Tumors, Green fluorescent protein, Optical imaging, Luminescence, Visualization, Liver, Colon, In vivo imaging, Surgery, Melanoma

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Proceedings Article | 2 July 1999 Paper

Green fluorescent protein: new light to visualize metastasis and angiogenesis in cancer

Meng Yang, Takashi Chishima, Eugene Baranov, Hiroshi Shimada, A. Moossa, Robert Hoffman

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351020

KEYWORDS: Tumors, Green fluorescent protein, Visualization, Animal model studies, Cancer, Luminescence, Tissues, Lung, Lung cancer, Tumor growth modeling

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