Mr. Robert I. Loshkarev Profile

Robert I. Loshkarev

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Proceedings Article | 9 April 2020 Paper

Opening the BBB could disable neurovascular coupling: the quantitative mathematical model prediction

Robert Loshkarev, Dmitry Postnov

Proceedings Volume 11459, 114590Q (2020) https://doi.org/10.1117/12.2565794

KEYWORDS: Neurons, Potassium, Mathematical modeling, Blood brain barrier, Neurovascular coupling, Calcium, Ion channels, Receptors, Brain, Ions

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The concept of neurovascular unit (NVU) is used to denote cells and their communication mechanisms involved in the formation of autoregulation of blood supply. It has been shown that the "opening" of blood-brain barrier (BBB) can be caused by different types of effects, such as a strong and prolonged sound, or by laser irradiation. It has been noted that the BBB opening is accompanied by perivascular edema, as capillary permeability to water also increases many times. Thus, one can expect that such changes can significantly affect the operational mode of neurovascular unit. We present the model study aimed to estimate the impact of perivascular edema on the functioning of neurovascular coupling using a multidimensional quantitative mathematical model. Our results predict the blocking of neurovascular communication operation when BBB is opened. Namely, we show that a relatively small (2-3 times) change in perivascular volume has a subtle effect, a 10-fold increase in PVS changes markedly, but does not violate the functionality of neurovascular coupling, and a significant degree of edema (increase in PVS more than 100 times) almost completely turns off the neurovascular coupling.

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