Dr. Ryo Kubota Profile

Dr. Ryo Kubota

at Kubota Vision Inc

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Proceedings Article | 11 August 2023 Paper

Low-cost retinal imaging for disease progression monitoring at home

Ryo Kubota, Stefan Troller, Matthias Pfister

Proceedings Volume 12632, 1263207 (2023) https://doi.org/10.1117/12.2670574

KEYWORDS: Retinal diseases, Retinal scanning, Algorithm development, Vertical cavity surface emitting lasers, Tablets, Signal processing, Neural networks, Medical devices, Light sources, Design and modelling

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The unmet medical need of continuously monitoring retinal disease progression asks for an affordable and easy to use medical device that can be used multiple times per week at the patient’s home. A retinal monitor system has been designed for home use, has been built, and tested in a clinical study. The retinal monitor system consists of a handheld device operated by the patient, a tablet with an application, and cloud software. The retinal monitor system has been optimized for low production cost and ease of use for elderly patients while a minimum required performance has been assured to detect changes of retinal thickness and the presence of fluid. Component costs are optimized by relying on the wavelength-tuning capabilities of a VCSEL light source. The small form factor, the lightweight design and an auto-capture functionality enable patients to operate the retinal monitor on their own. The limited performance of low-cost components is compensated by sophisticated signal processing including a deep neural network. Clinical data has been acquired on 20 healthy and 50 diseased eyes to develop the algorithm and estimate the device performance. The clinical results indicate a 95% sensitivity and 95% specificity to detect a change of ±25 μm. Moreover, presence of fluid has been detected with a true positive rate of 97% and a true negative rate of 92%.

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