Dr. Saabah B. Mahbub Profile

Dr. Saabah B. Mahbub

Research fellow at Univ of New South Wales

SPIE Involvement:

Author

Proceedings Article | 2 March 2022 Presentation + Paper

Label-free assessment of Panc-1 cells viability and changes in metabolic fluorophores followed by radiodynamic therapy (RDT)

Shannon Handley, Saabah Mahbub, Sandhya Clement, Ayad Anwer, Ewa Goldys

Proceedings Volume 11972, 1197202 (2022) https://doi.org/10.1117/12.2608479

KEYWORDS: Nanoparticles, X-rays, Luminescence, Photodynamic therapy, Hyperspectral imaging, Data modeling, Cell death, Confocal microscopy, Cancer

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Proceedings Article | 5 March 2021 Poster

Reactive oxygen species (ROS) measurement using multispectral auto-fluorescence imaging technique: a real-time and label-free technology

Abbas Habibalahi, Mahdieh Dashtbani, Jared Campbell, Ayad Anwer, Saabah Mahbub, Martin Gosnell, Sonia Saad, Carol Pollock, Ewa Goldys

Proceedings Volume 11655, 116551O (2021) https://doi.org/10.1117/12.2582863

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Proceedings Article | 5 March 2021 Presentation

Label-free multispectral identification of native fluorophores to assess embryo and oocyte quality

Saabah Mahbub, Jared Campbell, Tiffany C. Tan, Abbas Habibalahi, Michael Bertoldo, Dale Goss, Kirsty Walter, Lindsay Wu, Kylie Dunning, Ewa Goldys

Proceedings Volume 11647, 116471C (2021) https://doi.org/10.1117/12.2579141

KEYWORDS: Biological research, Analytical research, Tissues, Pathology, Nondestructive evaluation, Microscopy, Medical diagnostics, Luminescence, Hyperspectral imaging

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Proceedings Article | 5 March 2021 Presentation

Quantitative label-free characterisation and discrimination of osteoarthritis and rheumatoid arthritis based on hyperspectral autofluorescence features

Saabah Mahbub, Jared Campbell, Florence Lees, Anna Guller, Martin Gosnell, Ayad Anwer, Tania Crotti, Mihir Wechalekar, Mark Hutchinson, Ewa Goldys

Proceedings Volume 11655, 116551I (2021) https://doi.org/10.1117/12.2578486

KEYWORDS: Arthritis, Hyperspectral imaging, Cartilage, Bone, Visualization, Tissues, Inflammation

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Proceedings Article | 5 March 2021 Presentation

Pancreatic islet characterisation by the hyperspectral Assessment of autofluorescence: a non-invasive, label-free measure of viability

Jared Campbell, Stacey Walters, Saabah Mahbub, Abbas Habibalahi, Ayad Anwer, Shane Grey, Ewa Goldys

Proceedings Volume 11655, 1165506 (2021) https://doi.org/10.1117/12.2578220

KEYWORDS: Transplantation, Ischemia, Receivers, Oxygen, Microscopy, Inflammation, Hyperspectral imaging, Glucose, Blood

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Proceedings Article | 10 March 2020 Presentation

Label-free multispectral monitoring of functional state: from embryos to human articular cartilage tissue (Conference Presentation)

Saabah Mahbub, Jared Campbell, Tiffany C. Tan, Kylie Dunning, Abbas Habibalahi, Michael Bertoldo, Dale Goss, Lindsay Wu, Ewa Goldys

Proceedings Volume 11251, 112510H (2020) https://doi.org/10.1117/12.2545265

KEYWORDS: Tissues, Cartilage, Biological research, Analytical research, Nondestructive evaluation, Medical diagnostics, Luminescence, Microscopy, Data processing, Cancer

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Proceedings Article | 20 February 2020 Presentation + Paper

Multispectral characterisation of mesenchymal stem/stromal cells: age, cell cycle, senescence, and pluripotency

Jared Campbell, Abbas Habibalahi, Saabah Mahbub, Sharon Paton, Stan Gronthos, Ewa Goldys

Proceedings Volume 11251, 112510F (2020) https://doi.org/10.1117/12.2544623

KEYWORDS: Microscopy, Stem cells, Multispectral imaging, Tissues, Fluorescence lifetime imaging, Receivers, Transplantation, Bone, In vitro testing, Cancer

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Proceedings Article | 30 December 2019 Paper

Hyperspectral imaging of the early embryo: can it detect chromosome abnormalities and predict IVF success?

Tiffany C. Tan, Carl Campugan, Saabah Mahbub, Jared Campbell, Abbas Habibalahi, Sanam Mustafa, Ewa Goldys, Jeremy Thompson, Kylie Dunning

Proceedings Volume 11202, 112020M (2019) https://doi.org/10.1117/12.2541282

KEYWORDS: Hyperspectral imaging, Mode conditioning cables, Biopsy, Medical research, Fetus, Biomedical optics, Biomedical engineering, In vitro testing, Diagnostics, Diagnostic tests

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Proceedings Article | 13 March 2019 Presentation

Label-free multispectral imaging for biological research and medical diagnostics (Conference Presentation)

Ewa Goldys, Jared Campbell, Saabah Mahbub, Abbas Habibalahi, Ayad Anwer, Martin Gosnell

Proceedings Volume 10890, 108900F (2019) https://doi.org/10.1117/12.2509130

KEYWORDS: Multispectral imaging, Biological research, Medical diagnostics, Tissues, Mode conditioning cables, Cancer, Auto-fluorescence imaging, Luminescence, Oxygen, Molecular mechanisms

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Proceedings Article | 4 March 2019 Presentation

Hyperspectral imaging of the early embryo: can it detect chromosome abnormalities and predict IVF success? (Conference Presentation)

Kylie Dunning, Carl Campugan, Tiffany C. Tan, Saabah Mahbub, Ewa Goldys, Jeremy Thompson

Proceedings Volume 10890, 108900I (2019) https://doi.org/10.1117/12.2510912

KEYWORDS: Hyperspectral imaging, Mode conditioning cables, Biopsy, Diagnostics, Cancer, Mouse models, Spindles

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Proceedings Article | 4 March 2019 Presentation

Non-invasive monitoring of functional state of articular cartilage tissue with label-free unsupervised hyperspectral imaging (Conference Presentation)

Saabah Mahbub, Anna Guller, Martin Gosnell, Ayad Anwer, Ewa Goldys

Proceedings Volume 10890, 108900D (2019) https://doi.org/10.1117/12.2510768

KEYWORDS: Cartilage, Tissues, Hyperspectral imaging, Collagen, Luminescence, Biological research, Stem cells, Multispectral imaging

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Degradation of cartilage, occurring in osteoarthritis and other conditions leads to pain and reduced mobility. Current treatments beyond anti-inflammatories include intra-articular injections of hyaluronan or preparations based on adult mesenchymal stem cells (MSC), the latter shown to aid cartilage regeneration which requires the assessment of the cartilage, best on a molecular level and in a minimally invasive way. However, the conventional methods are invasive, destroying and can only provide a snapshot of a tissue structure and functional state on a sample-by-sample basis, while the continuous monitoring and high-throughput assays require low-invasive biopsy-free approach. As a first step to address this problem, in current work, we explored the potential of label-free multispectral imaging of endogenous tissue fluorescence to characterise the molecular composition, structure and functional status of ex vivo healthy bovine and osteoarthritic (OA) human knee articular cartilage followed by monitoring the effects of experimental treatment of OA cartilage performed ex vivo. However, strong autofluorescence of collagens (especially from collagen type II, which is the structural backbone of collagen fibrils) from various cartilage layers presents a challenge, because this signal tends to overpower the fluorescence from chondrocytes. We have managed to use Robust Dependent Component Analysis (RoDECA) to observe the detailed metabolic information with a proper account of intrinsic cellular heterogeneity, which signifies the sophisticated quantitative biochemical analysis. This work reports on the “signatures” of the healthy articular cartilage for superficial and transitional layer, define the “healthy range” of each fluorophore’s abundance and localization of chondrocytes non-invasively as well as identify the changes of the signatures in OA cartilage of real patients and observe the reaction of the OA cartilage on 2 types of experimental treatments.

Proceedings Article | 14 March 2018 Presentation

Label-free unsupervised hyperspectral analysis for regenerative treatments on various cartilage layers (Conference Presentation)

Saabah Mahbub, Martin Gosnell, Ayad Anwer, Ewa Goldys

Proceedings Volume 10497, 104970I (2018) https://doi.org/10.1117/12.2289864

KEYWORDS: Cartilage, Collagen, Stem cells, Therapeutics, Hyperspectral imaging, Tissues, Biological research, Tissue optics, Luminescence, Imaging spectroscopy

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Proceedings Article | 17 May 2016 Presentation

Deconstructing autofluorescence: non-invasive detection and monitoring of biochemistry in cells and tissues (Conference Presentation)

Ewa Goldys, Martin Gosnell, Ayad Anwer, Juan Cassano, Carolyn Sue, Saabah Mahbub, Sandeep Pernichery, David Inglis, Partho Adhikary, Jalal Jazayeri, Michael Cahill, Sonia Saad, Carol Pollock, Melanie Sutton-Mcdowall, Jeremy Thompson

Proceedings Volume 9703, 97030R (2016) https://doi.org/10.1117/12.2212443

KEYWORDS: Tissues, Luminescence, Biochemistry, Multispectral imaging, Stem cells, Biology, Medicine, Image processing, Microscopes, Genetics

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Proceedings Article | 27 April 2016 Presentation

Non-invasive monitoring of cytokine-based regenerative treatment of cartilage by hyperspectral unmixing (Conference Presentation)

Saabah Mahbub, Peter Succer, Martin Gosnell, Ayad Anwaer, Benjamin Herbert, Graham Vesey, Ewa Goldys

Proceedings Volume 9698, 96980B (2016) https://doi.org/10.1117/12.2212336

KEYWORDS: Cartilage, Tissues, Stem cells, Therapeutics, Bone, In vitro testing, Biomedical optics, Diagnostics, Current controlled current source

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Showing 5 of 14 publications

Conference Committee Involvement (1)

Biophotonics Australasia 2019

9 December 2019 |

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