Dr. Sacha Loiseau Profile

Dr. Sacha Loiseau

Founder, Chairman & CEO at Mauna Kea Technologies

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 14 February 2007 Paper

To see the unseeable: confocal miniprobes for routine microscopic imaging during endoscopy

A. Osdoit, F. Lacombe, Charlotte Cavé, S. Loiseau, E. Peltier

Proceedings Volume 6432, 64320F (2007) https://doi.org/10.1117/12.701004

KEYWORDS: Confocal microscopy, Imaging systems, Endoscopy, Lung, Tissues, In vivo imaging, Magnetic resonance imaging, Luminescence, Pulmonology, Biopsy

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Confocal fluorescence high resolution imaging during standard endoscopic procedures has been presented as a very promising tool to enhance patient care and physician practice by providing supplementary diagnostic information in real-time. The purpose of this paper is to show not only potential, but convincing results of endoscopic microscopy using a catheter-based approach. Mauna Kea Technologies' core technology, Cellvizio, delivers dynamic imaging at 12 frames/second using confocal miniprobes inserted through the operating channel of regular endoscopes. Cellvizio is composed of 3 parts including (a) a Laser Scanning Unit, (b) Confocal Miniprobe^TM with the following characteristics: 5-15 &mgr;m axial resolution, 2-5 &mgr;m lateral resolution, 15-100 &mgr;m depth of penetration, field of view of 600x500 &mgr;m and (c) a software package with onthe- fly processing capabilities. With several tens of patients examined during routine GI endoscopy procedures, the most relevant clinical parameters could be assessed in a doubled-blinded fashion between the endoscopist and a pathologist and results showing very high accuracy in the differentiation of neoplasia from normal and hyperplastic tissue were obtained. In the field of pulmonology, the micro-autofluorescence properties of tissues could be assessed and structures never before accessed in vivo were observed. Cellvizio® may be useful to study bronchial remodeling in asthma and chronic obstructive pulmonary diseases. Using appropriate topical fluorescent dye, the Confocal Miniprobes may also make it possible to perform optical biopsy of precancerous and superficial bronchial cancers. Cellvizio® is as a new tool towards "targeted biopsies", leading to earlier, more reliable and cost effective diagnostic procedures. Other applications, specifically in molecular imaging are also made possible by the miniaturization of the probe (combination with biopsy needle for solid organs use or lymph node detection) and by the compatibility of the system with other imaging modalities (auto-fluorescence and narrow-band imaging endoscopy, MRI, PET, etc).

Proceedings Article | 23 February 2006 Paper

In vivo fibered confocal reflectance imaging: totally non-invasive morphological cellular imaging brought to the endoscopist

Anne Osdoit, Magalie Genet, Aymeric Perchant, Sacha Loiseau, Benjamin Abrat, François Lacombe

Proceedings Volume 6082, 608208 (2006) https://doi.org/10.1117/12.646659

KEYWORDS: Confocal microscopy, Tissues, In vivo imaging, Reflectivity, Imaging systems, Microscopy, Image resolution, Endoscopes, Chemical elements, Optical fibers

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Proceedings Article | 23 February 2006 Paper

Mauna Kea technologies’ F400 prototype: a new tool for in vivo microscopic imaging during endoscopy

B. Viellerobe, A. Osdoit, C. Cavé, F. Lacombe, S. Loiseau, B. Abrat

Proceedings Volume 6082, 60820C (2006) https://doi.org/10.1117/12.646625

KEYWORDS: Luminescence, In vivo imaging, Endoscopy, Confocal microscopy, Endoscopes, Tissues, Prototyping, Image resolution, Biopsy, Standards development

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Proceedings Article | 24 July 1998 Paper

Retroreflector diffraction modeling

Sacha Loiseau, Stuart Shaklan, David Redding, Edouard Schmidtlin

Proceedings Volume 3350, (1998) https://doi.org/10.1117/12.317186

KEYWORDS: Metrology, Diffraction, Retroreflectors, Cameras, Mirrors, Wavefronts, Reflection, Interferometry, Systems modeling, Near field optics

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Proceedings Article | 1 November 1997 Paper

Raman studies on single-walled carbon nanotubes

Serge Lefrant, M. Lamy de la Chapelle, C. Journet, W. Maser, Patrick Bernier, Alexandre Loiseau

Proceedings Volume 3142, (1997) https://doi.org/10.1117/12.293354

KEYWORDS: Raman spectroscopy, Single walled carbon nanotubes, Carbon, Spectroscopy, Microscopes, Raman scattering, Electron microscopy, Scanning electron microscopy, X-ray diffraction, Laser ablation

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Proceedings Article | 26 June 1995 Paper

Global astrometric interferometer for astrophysics (GAIA)

Lennart Lindegren, Michael Perryman, Sacha Loiseau

Proceedings Volume 2477, (1995) https://doi.org/10.1117/12.213006

KEYWORDS: Stars, Sensors, Modulation, Charge-coupled devices, Interferometers, Phase shift keying, Interferometry, Mirrors, Photometry, Imaging systems

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Proceedings Article | 26 June 1995 Paper

Global astrometry with OSI

Sacha Loiseau, Fabien Malbet, Jeffrey Yu

Proceedings Volume 2477, (1995) https://doi.org/10.1117/12.212997

KEYWORDS: Stars, Interferometers, Optical spheres, Satellites, Metrology, Space operations, Computer simulations, Information technology, Osmium, Michelson interferometers

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Proceedings Article | 2 June 1995 Paper

Optical design for the Global Astrometric Interferometer for Astrophysics

Sacha Loiseau, Stuart Shaklan

Proceedings Volume 2478, (1995) https://doi.org/10.1117/12.210930

KEYWORDS: Visibility, Interferometers, Mirrors, Telescopes, Fizeau interferometers, Diffraction, Astrophysics, Stars, Optical instrument design, Optical design

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Proceedings Article | 9 June 1994 Paper

GAIA: global astrometric interferometer for astrophysics

Lennart Lindegren, Michael Perryman, Ulrich Bastian, Christopher Dainty, E. Hog, F. van Leeuwen, J. Kovalevsky, Antoine Labeyrie, Sacha Loiseau, F. Mignard, Jacco Noordam, Rudolf le Poole, P. Thejll, Farrokh Vakili

Proceedings Volume 2200, (1994) https://doi.org/10.1117/12.177278

KEYWORDS: Stars, Modulation, Interferometers, Charge-coupled devices, Sensors, Satellites, Interferometry, Phase shift keying, Telescopes, Galactic astronomy

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Showing 5 of 9 publications

Conference Committee Involvement (13)

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII

29 January 2024 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXI

30 January 2023 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX

24 January 2022 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX

6 March 2021 | Online Only, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII

3 February 2020 | San Francisco, California, United States

Showing 5 of 13 Conference Committees

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