Infrared neural modulation is an optical technique to stimulate or inhibit neural activity with pulsed infrared light (IR). This study focuses on effects of IR and heat on microglial calcium signaling, a main indicator of physiological changes within the immune-like cell. Widefield fluorescence microscopy quantified the intracellular calcium fluxes, cell death, and early apoptosis fluorescent indicators in BV2 immortalized microglia cell culture after irradiation. We have found that unique cellular responses are highly associated with different temperature increases, and the irradiance thresholds for these responses do not drive cells to Caspase-3 apoptosis nor necrotic cellular death.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.