Optical Coherence Tomography Angiography (OCTA), a functional extension of Optical Coherence Tomography (OCT), is capable of imaging blood flow signals non-invasively at the capillary level without the need for dye injection. However, widespread usage of OCTA is hindered by the trade-off between transverse sampling rate and Signal to Noise Ratio (SNR). To achieve a clinically applicable field of view, capillary fine details are commonly sacrificed due to under-sampling. In addition, the image contrast of capillaries suffers from 'thin line' motion artifacts. We introduce spectrally extended line field OCTA (SELF-OCTA) that tackles the above-mentioned issues with parallel transverse sampling and increased allowable light exposure. We show that SELF-OCTA provides significantly improved sampling density and image contrast for microvasculature compared with the standard OCTA technique.
We have developed a novel scanning protocol based on Spectrally Extended Line Field OCTA (SELF-OCTA) to realize 4 interscan times ranging from 0.54 ms to 5.4 ms without increasing A-scan repetitions at the same position. Based on the linear model, we further developed signal processing methods to realize high dynamic range blood flow map by concatenating the dynamic range of 3 interscan time: 0.54 ms, 1.35 ms and 2.70 ms. The differential OCTA signals provided by different interscan times help with flow dynamic range extension and blood flow evaluation.
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