A complex instrument is ordinarily used in electrochemiluminescence (ECL) biosensors to monitor the emitted light from the chemiluminescence reaction. As a result, these biosensors may not be suitable for point-of-need (PON) testing, which is critical in healthcare diagnostics. Microfluidic and luminol-based ECL systems were integrated on a CMOS chip to create a miniaturized ECL sensor for PON applications in this study. The findings demonstrated that this novel lab-on-a-chip system could detect uric acid levels as an essential biomarker for diagnosing gout disease in urine and saliva at levels lower than the physiological range. The device's repeatability, reproducibility, and selectivity were also investigated.
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