Usually, the response of biological cells to electrical excitations is given by its dipolar part. In addition to that, the shape models of the cells are restrained, in general, to ellipsoidal shape and, in particular, to spherical or spheroidal shapes. However, the electric/dielectric response of the live cells may contain higher multipolar components whose origins comes from the cell shape (other than the ellipsoidal one) and from the multipolar parts of the applied field. In the present work we consider the response of arbitrarily-shaped cells beyond dipolar approximation. We use a boundary integral equation (BIE) method that intrinsically includes all multipolar orders of the response. For small field non-uniformity, we show that although a cell of a certain shape has a relatively large higher order multipolar term in its dielectric response, the dielectrophoretic force is accurately modeled with the dipolar response of a close spherical cell.
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