The spectral sensitivity of conventional prism-based SPR sensors is numerically investigated and found to increase rapidly with the RI of the analyte. The sensitivity could be greatly enhanced by means of setting the x_component of the effective RI of the incident light a little larger than the RI of the analyte mainly on account of a large dielectric permittivity of the SPR active material which is essential in just mentioned approach in order to satisfy the coupling condition of SPR.
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