Ms. Xiaopu Wang Profile

Xiaopu Wang

at Technical Institute of Physics and Chemistry

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Proceedings Article | 21 November 2014 Paper

Initiation efficiency and cytotoxicity of a series of water-soluble benzylidene cyclopentanone for two-photon polymerization

Xiaopu Wang, Yanyan Fang, Qianli Zou, Yuxia Zhao, Feipeng Wu

Proceedings Volume 9268, 926824 (2014) https://doi.org/10.1117/12.2071644

KEYWORDS: Two photon polymerization, Tissue engineering, Absorption, Luminescence, Polymerization, Toxicity, Safety, 3D applications, Femtosecond phenomena, Neodymium

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The 3D fabrication of bio-compatible materials under an aqueous environment is a fundamental requirement for tissue engineering. In this work, a series of polyethylene glycol- (PEG-), carboxylate anionic group- or pyridyl cationic groupfunctionalized benzylidene cyclopentanone photo-initiators (B₂, B₃, X₂, X₃, Y₁ and P₁) were synthesized. Their water-solubility, photophysical properties and cytotoxicity were investigated. Using eosin as reference, their initiation efficiencies in water-soluble photoactive formulation (SR610 with 20% of DI water) excited by one- or two-photon were studied. The results showed that there were no significant differences on partial linear photophysical properties of these initiators, such as [see manuscript] and [see manuscript], but differences on their (see manuscript), Φ, and σ_max are clear. In addition, their cytotoxicity is different. Two PEG-functionalized initiators (B₃ and X₃) with two PEG groups on one side of benzylidene cyclopentanone cores have obvious toxicity, while other four intiators are safety to HepG2 cells at the concentration of 20 μM. Moreover, the water-solubility of X₂ and X₃ (containing two longer PEG) were much better than those of other four initiators. Using these initiators, 3D micro-structures fabricated by two-photon polymerization of water-soluble acrylate all could be achieved. In addition, their threshold energies were all lower than 0.5 mW. However, the stiffness of 3D micro-structures was affected by the water-solubility of these photo-initiators. Those structures built by formulations containing X₂ and X₃ would collapse easily. Conversely, other structures could sustain very well. This work proves that B₂，Y₁，and P₁ have extensive application prospects in 3D fabrication for tissue engineering.

Proceedings Article | 18 November 2014 Paper

Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy

Yanyan Fang, Xiaopu Wang, Qianli Zou, Yuxia Zhao, Feipeng Wu

Proceedings Volume 9268, 92680O (2014) https://doi.org/10.1117/12.2071756

KEYWORDS: Photodynamic therapy, In vitro testing, Oxygen, Absorption, Quantum efficiency, Toxicity, Tumors, Luminescence, Tissues, Receptors

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A series of amphiphilic benzylidene cycloalkanes ketone photosensitizers C1-C4 with or without folate receptor-targeted agent were designed and synthesized. Their photophysical properties and in vitro photodynamic therapy (PDT) effects were studied. The results showed that all compounds exhibited appropriate lipid-water partition coefficients and high reactive oxygen yields. The introduction of the folate receptor-targeted agent had no obvious influence on the basic photophysical & photochemical properties of C2 and C4 compared to those of their corresponding prototype compounds (C1 and C3). In vitro studies were carried out using MCF-7 cells (FR+), Hela cells (FR+) and A549 cells (FR-), which represented different levels of folate receptor (FR) expression. All of C1-C4 showed low dark toxicity and superior PDT effects compared with the clinical drug PSD-007 (a mixture of porphyrins). What’s more, folate receptor-targeted photosensitizers (C2 and C4) achieved higher accumulation and more excellent PDT effects in MCF-7 cells (FR+) and Hela cells (FR+) than photosensitizers (C1 and C3) without folate receptor-targeted agent and PSD-007. The photocytotoxicity of these photosensitizers showed no obvious differences in A549 cells (FR-).

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