Activated platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis, as well as in atherosclerosis and cancer. More recent studies demonstrate further an important role for platelets in generating a permissive microenvironment for tumor growth, and the promotion of invasion and metastasis. To advance the in vivo study of the biological activity of this activated cell type from basic experimental to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically-approved small molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through in vitro experiments with human platelets, and in vivo in a murine model of deep vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, thereby enabling rapid in vivo visualization within the vasculature
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.