Dr. Xiaoying Tian Profile

Dr. Xiaoying Tian

at Shanghai Jiao Tong Univ

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Proceedings Article | 20 November 2019 Paper

Ultrahigh-resolution stimulation by femtosecond laser reveals existence and regulation mechanism of nuclear Ca2+ store

Xiaoying Tian, Hao He

Proceedings Volume 11190, 111901N (2019) https://doi.org/10.1117/12.2537703

KEYWORDS: Femtosecond phenomena, Photostimulation, Calcium, Detection theory, Cell mechanics

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Nuclear Ca²⁺ regulates many signaling pathways including NFAT, CREB, MEF that are essential to cell immunity, development and differentiation. In current stage, there is no specified biochemical drugs to regulate nuclear Ca²⁺ individually. The existence of nuclear Ca²⁺ store remains unknown. In this study, we show the femtosecond-laser stimulation can precisely regulate nuclear and other subcellular Ca²⁺ stores exclusively. The stimulated Ca²⁺ store can be released but other subcellular Ca²⁺ stores are not interfered by femtosecond laser. By using this method, we present the evidence of the endogenous Ca²⁺ store inside nucleus. The nuclear Ca²⁺ store volume and release mechanism are clarified. By photostimulation, nuclear Ca²⁺ store can be released and impact the calcium in endoplasmic reticulum (ER), suggesting a Ca²⁺ transmission channel between nucleus and ER. The permeability of nuclear pore complex (NPC) to Ca²⁺ at different Ca²⁺ levels is also found different. This study indicates the existence of nuclear Ca²⁺ store and the final mapping of subcellular Ca²⁺ stores. This result thus is of great significance to the cell calcium theory, Ca²⁺ signaling, Ca²⁺-related cell processes, and further other Ca²⁺-related fields.

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