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6 February 2019 Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis
Arseniy A. Gavdush, Nikita V. Chernomyrdin, Kirill M. Malakhov, Sheyh-Islyam T. Beshplav, Irina N. Dolganova, Alexandra V. Kosyrkova, Pavel V. Nikitin, Guzel R. Musina, Gleb M. Katyba, Igor V. Reshetov, Olga P. Cherkasova, Gennady A. Komandin, Valery E. Karasik, Alexander A. Potapov, Valery V. Tuchin, Kirill I. Zaytsev
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Journal of Biomedical Optics, Vol. 24, Issue 2, 027001 (February 2019). https://doi.org/10.1117/1.JBO.24.2.027001
Abstract
We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed according to further histological examination. In order to fix tissues for the THz measurements, we applied gelatin embedding, which allows for sustaining their THz response unaltered, as compared to that of the freshly excised tissues. We observed a statistical difference between the THz optical constants of intact tissues and gliomas of grades I to IV, while the response of edema was similar to that of tumor. The results of this paper justify a potential of THz technology in the intraoperative label-free diagnosis of human brain gliomas for ensuring the gross-total resection.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Arseniy A. Gavdush, Nikita V. Chernomyrdin, Kirill M. Malakhov, Sheyh-Islyam T. Beshplav, Irina N. Dolganova, Alexandra V. Kosyrkova, Pavel V. Nikitin, Guzel R. Musina, Gleb M. Katyba, Igor V. Reshetov, Olga P. Cherkasova, Gennady A. Komandin, Valery E. Karasik, Alexander A. Potapov, Valery V. Tuchin, and Kirill I. Zaytsev "Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis," Journal of Biomedical Optics 24(2), 027001 (6 February 2019). https://doi.org/10.1117/1.JBO.24.2.027001
Received: 26 November 2018; Accepted: 11 January 2019; Published: 6 February 2019
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KEYWORDS
Tissues
Terahertz radiation
Brain
Tumors
Imaging spectroscopy
Terahertz spectroscopy
Spectroscopy
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