Optomechanics intended for flight applications on satellite, rocket, or high altitude balloon payloads have special design requirements in addition to those necessary for earth-based systems. Space environment conditions such as micro-gravity, vacuum, radiation, temperature gradients, and jitter impose special constraints on optomechanical design. Optics and their mounts must not only survive launch loads, but also meet mass and envelope restrictions, maintain precision alignment, and demonstrate long-term stability. Further, these systems must operate remotely once they arrive on-orbit and remain reliable throughout the life of the mission. This course reviews environmental conditions for common orbits, spacecraft, and launch vehicles and describes how they influence optomechanical design requirements. The effect of space conditions on materials is covered in detail. Participants are provided with tools necessary for selecting suitable structural and optical materials, lubricants, and adhesives for flight design. Optomechanical principles appropriate for flight designs are reviewed and methods for resolving common design issues are presented. Flight design examples related to course topics are covered in detail at the end of the day.