Dr. Christine Tanner Profile

Dr. Christine Tanner

at University of Basel

SPIE Involvement:

Author

Publications (29)

Proceedings Article | 17 November 2022 Presentation + Paper

Three-dimensional imaging of porcine joints down to the subcellular level

Georg Schulz, Andrea Barbero, Francine Wolf, Griffin Rodgers, Christine Tanner, Timm Weitkamp, Marcus Mumme, Marta Morawska, Daniel Beer, Bert Müller

Proceedings Volume 12242, 1224215 (2022) https://doi.org/10.1117/12.2635223

KEYWORDS: Cartilage, Tissues, Bone, Visualization, Bioalcohols, Laser ablation, Synchrotrons, Tomography, X-rays, Spatial resolution

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Proceedings Article | 10 November 2022 Paper

Tomographic imaging of unique objects: annual layers in tooth cementum of Anna Catharina Bischoff born 1719

Jeannette Von Jackowski, Bert Müller, Georg Schulz, Gerhard Hotz, Timm Weitkamp, Ursula Wittwer-Backofen, Christine Tanner

Proceedings Volume 12242, 122421O (2022) https://doi.org/10.1117/12.2635312

KEYWORDS: Teeth, Cements, Tomography, Photomicroscopy, Synchrotrons, Optical microscopy, Spatial resolution, Radiography, Computed tomography, Visualization

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Proceedings Article | 10 November 2022 Paper

Three-dimensional imaging of human teeth: an in vitro study of caries detection using micro computed tomography

Andrés Izquierdo, Christine Tanner, Georg Schulz, Jeannette von Jackowski, Griffin Rodgers, Hans Deyhle, Bert Müller

Proceedings Volume 12242, 122421P (2022) https://doi.org/10.1117/12.2635624

KEYWORDS: Dental caries, Teeth, Tissues, Image segmentation, Tomography, Radiography, Absorption, X-rays, In vitro testing, Visualization

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Proceedings Article | 14 October 2022 Presentation + Paper

Registration of microtomography images: challenges and approaches

Christine Tanner, Bert Müller, Griffin Rodgers

Proceedings Volume 12242, 122420T (2022) https://doi.org/10.1117/12.2633922

KEYWORDS: Image registration, Image registration, Teeth, Teeth, Tissues, Tissues, Image segmentation, Image segmentation, Dental caries, Dental caries, Image fusion, Image fusion, 3D modeling, 3D modeling, Brain, Brain, Tomography, Tomography, Image resolution, Image resolution

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Proceedings Article | 14 October 2022 Paper

Mosaic microtomography of a full mouse brain with sub-micron pixel size

Griffin Rodgers, Christine Tanner, Georg Schulz, Timm Weitkamp, Mario Scheel, Marta Girona Alarcón, Vartan Kurtcuoglu, Bert Müller

Proceedings Volume 12242, 122421L (2022) https://doi.org/10.1117/12.2633556

KEYWORDS: Brain, Tomography, Neuroimaging, Reconstruction algorithms, Sensors, Image segmentation, MATLAB, Visualization, Brain mapping, Synchrotrons

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Proceedings Article | 14 October 2022 Presentation + Paper

Nano-tomography of dental composites with wide color matching

Mattia Humbel, Mario Scheel, Christine Tanner, Griffin Rodgers, Georg Schulz, Corinne Carlucci, Jeannette von Jackowski, Guido Sigron, Andrés Izquierdo, Timm Weitkamp, Bert Müller

Proceedings Volume 12242, 122420Q (2022) https://doi.org/10.1117/12.2635928

KEYWORDS: Composites, Particles, Transmittance, Monte Carlo methods, Refractive index, Optical spheres, Tomography, Polymers, Teeth, Photorefractive polymers, X-ray microscopy, Disordered photonic crystals

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Proceedings Article | 14 October 2022 Presentation + Paper

Hierarchical imaging of African bovid tooth cementum using x-ray microtomography

Adriana Velasco, Christine Tanner, Georg Schulz, Griffin Rodgers, Jeannette von Jackowski, Mattia Humbel, Timm Weitkamp, Henry Bunn, Bert Müller

Proceedings Volume 12242, 122420R (2022) https://doi.org/10.1117/12.2633043

KEYWORDS: Teeth, Cements, Synchrotrons, X-rays, X-ray imaging, Tomography, Visualization, Statistical analysis, Anthropology, Synchrotron x-ray imaging

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SPIE Journal Paper | 16 June 2022 Open Access

Three-dimensional analysis of aligner gaps and thickness distributions, using hard x-ray tomography with micrometer resolution

Rémi Ammann, Christine Tanner, Georg Schulz, Bekim Osmani, Prasad Nalabothu, Tino Töpper, Bert Müller

JMI, Vol. 9, Issue 03, 031509, (June 2022) https://doi.org/10.1117/12.10.1117/1.JMI.9.3.031509

KEYWORDS: Teeth, 3D modeling, Tomography, Temperature metrology, Image segmentation, Polymers, Data modeling, Transmittance, Hard x-rays, Bone

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Purpose: The morphology of a polymer aligner, designed according to an orthodontic treatment plan, determines clinical outcomes. A fundamental element of orthodontic tooth movement with aligner treatment is the fit of the aligner’s surface to the individual teeth. Gaps between the aligner and teeth do occur because current aligner fabrication is not capable of completely reproducing the complex anatomy of the individual denture. Our study aims at a quantitative three-dimensional assessment of the fit between optically transparent aligners placed on a polymeric model of the upper dental arch for two thermofoil thicknesses at preselected thermoforming temperatures. Approach: Using an intraoral scan of a subject’s upper dental arch, eight models were printed using a stereolithographic system. A series of eight NaturAligners® was manufactured with a pressure molding process, using thermofoils with thicknesses of 550 and 750 μm and preselected process temperatures between 110°C and 210°C. These aligners placed on the corresponding models were imaged by an advanced micro computed tomography system. The aligners and the models were segmented to extract the gaps and aligners’ local thicknesses as a function of the processing temperature for the two foil thicknesses. Results: The results indicate that the aligners show a better fit when the foils are processed at higher temperatures. Nevertheless, processing temperatures can be kept below 150°C, as the gain becomes negligible. Thermal processing reduces the average thickness of the aligners to 60% with respect to the planar starting foil. These thickness distributions demonstrate that the aligners are generally thicker on the occlusal surfaces of molars and premolars but thinner around the incisors and buccal as well as on oral surfaces. Conclusions: Hard x-ray tomography with micrometer resolution is a powerful technique employed to localize the gaps between aligners and teeth, and it also enables film thickness measurements after thermoforming. The thicker film on the occlusal surfaces is most welcome because of aligner abrasion during wear. The NaturAligner® surfaces consist of a 25-μm-thin cellulose layer, and thus the microplastics released via abrasion of less than this thickness are expected to be substantially less critical than for other commercially available, optically transparent aligners.

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Proceedings Article | 20 April 2022 Presentation + Paper

Three-dimensional imaging and analysis of annual layers in tree trunk and tooth cementum

Bert Müller, Muriel Stiefel, Griffin Rodgers, Mattia Humbel, Melissa Osterwalder, Jeannette von Jackowski, Gerhard Hotz, Adriana Velasco Guadarrama, Henry Bunn, Mario Scheel, Timm Weitkamp, Georg Schulz, Christine Tanner

Proceedings Volume 12041, 120410C (2022) https://doi.org/10.1117/12.2615148

KEYWORDS: Teeth, Tomography, Hard x-rays, Image segmentation, Spatial resolution, 3D image processing, X-rays, Visualization

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SPIE Journal Paper | 31 March 2022 Open Access

Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve

Alexandra Migga, Georg Schulz, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Holger Blank, Iwan Jerjen, Phil Salmon, William Twengström, Mario Scheel, Timm Weitkamp, Christian Schlepütz, Jan S. Bolten, Jörg Huwyler, Gerhard Hotz, Srinivas Madduri, Bert Müller

JMI, Vol. 9, Issue 03, 031507, (March 2022) https://doi.org/10.1117/12.10.1117/1.JMI.9.3.031507

KEYWORDS: Tomography, Teeth, Nerve, Spatial resolution, Hard x-rays, Cements, Synchrotrons, Imaging systems, Tissues, Data acquisition

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Purpose: Synchrotron radiation-based tomography yields microanatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compared the performance of three cutting-edge laboratory systems benchmarked by synchrotron radiation-based tomography for three specimens. As an additional criterion, the user-friendliness of the three microtomography systems was considered. Approach: The three tomography systems—SkyScan 2214 (Bruker-microCT, Kontich, Belgium), Exciscope prototype (Stockholm, Sweden), and Xradia 620 Versa (Zeiss, Oberkochen, Germany)—were given 36 h to measure three medically relevant specimens, namely, zebrafish larva, archaeological human tooth, and porcine nerve. The obtained datasets were registered to the benchmark synchrotron radiation-based tomography from the same specimens and selected ones to the SkyScan 1275 and phoenix nanotom m® laboratory systems to characterize development over the last decade. Results: Next-generation laboratory-based microtomography almost reached the quality achieved by synchrotron-radiation facilities with respect to spatial and density resolution, as indicated by the visualization of the medically relevant microanatomical features. The SkyScan 2214 system and the Exciscope prototype demonstrated the complementarity of phase information by imaging the eyes of the zebrafish larva. The 3-μm thin annual layers in the tooth cementum were identified using Xradia 620 Versa. Conclusions: SkyScan 2214 was the simplest system and was well-suited to visualizing the wealth of anatomical features in the zebrafish larva. Data from the Exciscope prototype with the high photon flux from the liquid metal source showed the spiral nature of the myelin sheaths in the porcine nerve. Xradia 620 Versa, with detector optics as typically installed for synchrotron tomography beamlines, enabled the three-dimensional visualization of the zebrafish larva with comparable quality to the synchrotron data and the annual layers in the tooth cementum.

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Proceedings Article | 12 October 2021 Presentation + Paper

Three-dimensional analysis of aligner gaps and thickness distributions using advanced laboratory-based hard x-ray tomography

Remi Ammann, Christine Tanner, Georg Schulz, Bekim Osmani, Prasad Nalabothu, Tino Töpper, Bert Müller

Proceedings Volume 11840, 1184008 (2021) https://doi.org/10.1117/12.2592821

KEYWORDS: Teeth, 3D modeling, Temperature metrology, Tomography, Data modeling, Bone, Polymers, Image segmentation, Hard x-rays, Optical properties

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Proceedings Article | 7 October 2021 Presentation + Paper

Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo

Alexandra Migga, Georg Schulz, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Holger Blank, Iwan Jerjen, Phil Salmon, William Twengström, Mario Scheel, Timm Weitkamp, Christian Schlepütz, Jan Bolten, Jörg Huwyler, Gerhard Hotz, Srinivas Madduri, Bert Müller

Proceedings Volume 11840, 118400T (2021) https://doi.org/10.1117/12.2597926

KEYWORDS: Teeth, Tomography, Nerve, Spatial resolution, Synchrotrons, Data acquisition, Tissues, Synchrotron radiation

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Proceedings Article | 7 October 2021 Presentation + Paper

Extended-field synchrotron microtomography for non-destructive analysis of incremental lines in archeological human teeth cementum

Christine Tanner, Griffin Rodgers, Georg Schulz, Melissa Osterwalder, Gabriela Mani-Caplazi, Gerhard Hotz, Mario Scheel, Timm Weitkamp, Bert Müller

Proceedings Volume 11840, 1184019 (2021) https://doi.org/10.1117/12.2595180

KEYWORDS: Teeth, Cements, Synchrotrons, Sensors, Tomography, Image segmentation, Radiography, Nondestructive evaluation, Linear filtering, Image enhancement

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Proceedings Article | 9 September 2021 Presentation + Paper

Impact of fixation and paraffin embedding on mouse brain morphology: a synchrotron radiation-based tomography study

Griffin Rodgers, Christine Tanner, Georg Schulz, Alexandra Migga, Timm Weitkamp, Willy Kuo, Mario Scheel, Melissa Osterwalder, Vartan Kurtcuoglu, Bert Müller

Proceedings Volume 11840, 118400P (2021) https://doi.org/10.1117/12.2595144

KEYWORDS: Brain, Bioalcohols, Tissues, Neuroimaging, Visualization, Synchrotrons, X-rays, Cerebellum

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Proceedings Article | 8 July 2021 Open Access

X-ray imaging of human brain tissue down to the molecule level

Bert Müller, Anna Khimchenko, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Georg Schulz

Proceedings Volume 11886, 1188613 (2021) https://doi.org/10.1117/12.2592603

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X rays have been used for medical imaging since RÖNTGEN's fascinating discovery 125 years ago. The first radiographs of human hands were made public less than a month after his famous paper. The conventional X-ray sources integrated into the CT-machines of today’s hospitals still rely on the same physical principles. X-ray imaging has traditionally offered high spatial resolution and low contrast for soft tissues such as the brain. Magnetic resonance imaging is therefore the method of choice for brain imaging in a clinical setting, although for cellular resolution studies it suffers from limited spatial resolution. The gold standard in post mortem brain imaging is histology, which involves fixation, embedding, physical sectioning, staining, and optical microscopy. Currently, section thickness limits isotropic voxel sizes to 20 μm. Advanced X-ray sources including synchrotron radiation facilities offer complementary modalities such as phase-contrast imaging and spatially resolved small-angle X-ray scattering. We showed that X-ray phase contrast of the human cerebellum with micrometer resolution yields complementary three-dimensional images to magnetic resonance microscopy with even better contrast and spatial resolution. Grating interferometry enabled us to visualize individual Purkinje cells in the nonstained cerebellum. Taking advantage of well-established paraffin embedding, Purkinje cells were visualized within the human cerebellum even with conventional instrumentation. Hard X-ray nano-holotomography allowed for label-free, three-dimensional neuroimaging beyond the optical limit with a spatial resolution below 100 nm. Spatially resolved smallangle X-ray scattering permitted the localization of periodic nanostructures such as myelin sheaths on square-inch brain slices and included the orientational information on the axons. These developments have contributed to the establishment of virtual histology and extended the conventional histology to the third dimension. Further advances are required to image the entire human brain with an isotropic micrometer resolution and to suitably handle the petabyte datasets.

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Proceedings Article | 8 July 2021 Open Access

Hard X-ray microtomography of Zebrafish larvae

Melissa Osterwalder, Jan Stephan Bolten, Griffin Rodgers, Mattia Humbel, Georg Schulz, Christine Tanner, Jörg Huwyler, Bert Müller

Proceedings Volume 11886, 1188614 (2021) https://doi.org/10.1117/12.2593119

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Proceedings Article | 31 March 2021 Presentation + Paper

Non-rigid registration to determine strain fields during mouse brain fixation and embedding

Griffin Rodgers, Georg Schulz, Willy Kuo, Mario Scheel, Vartan Kurtcuoglu, Timm Weitkamp, Bert Müller, Christine Tanner

Proceedings Volume 11586, 115860I (2021) https://doi.org/10.1117/12.2583632

KEYWORDS: Brain, X-ray microscopy, Tissues, Neuroimaging, Biological research, X-ray imaging, Tomography, Synchrotrons, Synchrotron radiation, States of matter

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Proceedings Article | 29 March 2021 Presentation + Paper

Three-dimensional x-ray microscopy of zebrafish larvae

Melissa Osterwalder, Jan Stephan Bolten, Griffin Rodgers, Georg Schulz, Christine Tanner, Emre Cörek, Jörg Huwyler, Bert Müller

Proceedings Volume 11586, 115860J (2021) https://doi.org/10.1117/12.2583639

KEYWORDS: X-ray microscopy, Nanoparticles, Tomography, Synchrotrons, Nanomaterials, Visualization, Toxicity, Tissues, Synchrotron radiation, Spatial resolution

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Proceedings Article | 13 March 2013 Paper

Population based modeling of respiratory lung motion and prediction from partial information

Dirk Boye, Golnoosh Samei, Johannes Schmidt, Gabor Székely, Christine Tanner

Proceedings Volume 8669, 86690U (2013) https://doi.org/10.1117/12.2007076

KEYWORDS: Lung, Motion models, Data modeling, Principal component analysis, Tumors, Data acquisition, 3D modeling, Image registration, Image segmentation, Prototyping

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Proceedings Article | 14 February 2012 Paper

Using fractional gradient information in non-rigid image registration: application to breast MRI

A. Melbourne, N. Cahill, C. Tanner, M. Modat, D. Hawkes, S. Ourselin

Proceedings Volume 8314, 83141Z (2012) https://doi.org/10.1117/12.911173

KEYWORDS: Image registration, Breast, Diffusion, Image enhancement, Brain, Magnetic resonance imaging, Computer simulations, Algorithm development, Neuroimaging, Image restoration

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Proceedings Article | 4 March 2011 Paper

Estimating corresponding locations in ipsilateral breast tomosynthesis views

Guido van Schie, Christine Tanner, Nico Karssemeijer

Proceedings Volume 7963, 796306 (2011) https://doi.org/10.1117/12.878239

KEYWORDS: Breast, Optical spheres, Digital breast tomosynthesis, Nipple, Tissues, Computer aided diagnosis and therapy, Mammography, Mathematical modeling, Data modeling

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Proceedings Article | 13 March 2010 Paper

An intensity-based approach to x-ray mammography: MRI registration

Thomy Mertzanidou, John Hipwell, Christine Tanner, David Hawkes

Proceedings Volume 7623, 76232Z (2010) https://doi.org/10.1117/12.843988

KEYWORDS: X-rays, Mammography, Image registration, Magnetic resonance imaging, Breast, X-ray imaging, 3D acquisition, 3D image processing, Detection and tracking algorithms, Computer simulations

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Proceedings Article | 13 March 2010 Paper

Detection of stable mammographic features under compression using simulated mammograms

Y. Jafar, J. Hipwell, C. Tanner, D. Hawkes

Proceedings Volume 7623, 76232W (2010) https://doi.org/10.1117/12.844124

KEYWORDS: Mammography, Breast, Image compression, X-rays, Image registration, Computer simulations, Tissues, 3D image processing, X-ray imaging, Breast cancer

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Proceedings Article | 13 March 2010 Paper

Cylindrical affine transformation model for image registration

Christine Tanner, Timothy Carter, David Hawkes, Gàbor Székely

Proceedings Volume 7623, 76232P (2010) https://doi.org/10.1117/12.843992

KEYWORDS: Image registration, Image segmentation, Breast, Computed tomography, Affine motion model, 3D modeling, Visual process modeling, Magnetic resonance imaging, Image restoration, Medical imaging

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Proceedings Article | 27 March 2009 Paper

Using statistical deformation models for the registration of multimodal breast images

Christine Tanner, John Hipwell, David Hawkes

Proceedings Volume 7259, 72590P (2009) https://doi.org/10.1117/12.811631

KEYWORDS: Breast, Image registration, Magnetic resonance imaging, 3D modeling, Finite element methods, Image compression, Statistical modeling, 3D image processing, Image segmentation, Tissues

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Proceedings Article | 13 March 2009 Paper

Determining material properties of the breast for image-guided surgery

Timothy Carter, Christine Tanner, David Hawkes

Proceedings Volume 7261, 726124 (2009) https://doi.org/10.1117/12.810092

KEYWORDS: Breast, Tissues, Image registration, Skin, Magnetic resonance imaging, Image segmentation, Image-guided intervention, Surgery, Finite element methods, Visualization

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Proceedings Article | 12 May 2004 Paper

Alignment of dynamic contrast-enhanced MR volumes of the breast for a multicenter trial: an exemplar grid application

Yalin Zheng, Christine Tanner, Derek Hill, David Hawkes, Mark White, Michael Khazen, Martin Leach

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.535151

KEYWORDS: Image registration, Breast, Magnetic resonance imaging, Medical imaging, Rigid registration, 3D image processing, Breast cancer, Mammography, Image segmentation, Computer security

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Proceedings Article | 9 May 2002 Paper

Comparison of biomechanical breast models: a case study

Christine Tanner, Andreas Degenhard, Julia Schnabel, Andrew Castellano-Smith, Carmel Hayes, Luke Sonoda, Martin Leach, D. Hose, Derek Hill, David Hawkes

Proceedings Volume 4684, (2002) https://doi.org/10.1117/12.467155

KEYWORDS: Breast, Tissues, Finite element methods, 3D modeling, Image registration, 3D image processing, Image compression, Magnetic resonance imaging, Natural surfaces, Skin

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Proceedings Article | 9 May 2002 Paper

Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography

Julia Schnabel, Christine Tanner, Andrew Castellano-Smith, Andreas Degenhard, Carmel Hayes, Martin Leach, D. Hose, Derek Hill, David Hawkes

Proceedings Volume 4684, (2002) https://doi.org/10.1117/12.467197

KEYWORDS: Image registration, Finite element methods, Tissues, Mammography, Breast, Computer simulations, Tumor growth modeling, 3D image processing, Chemical elements, Algorithm development

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Showing 5 of 29 publications

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