Dr. Paolo Matteini Profile

Dr. Paolo Matteini

at Istituto di Fisica Applicata "Nello Carrara"

SPIE Involvement:

Author

Publications (41)

Proceedings Article | 12 March 2024 Poster + Paper

Urban green proximal sensing with portable photonics-based devices: preliminary results in the metropolitan city of Cagliari

Francesca Sanfilippo, Lorenza Tuccio, Lucia Cavigli, Francesca Rossi, Giorgio Querzoli, Ivan Blecic, Paolo Matteini

Proceedings Volume 12879, 128790J (2024) https://doi.org/10.1117/12.3023415

KEYWORDS: Portability, Pollution, Photonic devices, Raman spectroscopy, Environmental monitoring, Ecosystems, Climate change, Sustainability, Environmental sensing, Photodetectors

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Proceedings Article | 9 December 2021 Paper

Label-free SERS/machine learning procedures for protein classification

Edoardo Farnesi, Andrea Barucci, Cristiano D'Andrea, Martina Banchelli, Chiara Amicucci, Marella de Angelis, Michael Schmitt, Paolo Matteini

Proceedings Volume 11920, 1192025 (2021) https://doi.org/10.1117/12.2615448

KEYWORDS: Proteins, Principal component analysis, Biological research, Statistical analysis, Data processing, Raman scattering, Photonics, Machine learning, Silver, Medicine

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Proceedings Article | 20 June 2021 Presentation + Paper

Electrospinnable composites for laser-activated tissue bonding and wound monitoring

Fulvio Ratto, Alessio Milanesi, Giada Magni, Sonia Centi, Gioacchino Schifino, Annalisa Aluigi, Boris Khlebtsov, Lucia Cavigli, Andrea Barucci, Paolo Matteini, Nikolai Khlebtsov, Roberto Pini, Francesca Rossi

Proceedings Volume 11786, 117861M (2021) https://doi.org/10.1117/12.2593263

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Proceedings Article | 5 March 2021 Presentation + Paper

Blue LED light photobiomodulation in cultured human fibroblasts and keratinocytes cell line

Giada Magni, Martina Banchelli, Federica Cherchi, Elisabetta Coppi, Michele Rossi, Marco Fraccalvieri, Anna Maria Pugliese, Paolo Matteini, Francesco Pavone, Francesca Rossi

Proceedings Volume 11628, 116280C (2021) https://doi.org/10.1117/12.2578249

KEYWORDS: Blue light emitting diodes, Wound healing, In vitro testing, Tissues, Raman spectroscopy, Potassium, Mode conditioning cables, Inflammation, In vivo imaging, Collagen

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SPIE Journal Paper | 2 July 2020 Open Access

Hollow core photonic crystal fiber-assisted Raman spectroscopy as a tool for the detection of Alzheimer’s disease biomarkers

Pinkie Eravuchira, Martina Banchelli, Cristiano D'Andrea, Marella De Angelis, Paolo Matteini, Israel Gannot

JBO, Vol. 25, Issue 07, 077001, (July 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.7.077001

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Photonic crystals, Alzheimer's disease, Proteins, Bioalcohols, Spectroscopy, Nanoparticles, Molecules

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Proceedings Article | 1 April 2020 Presentation

A SERS affinity bioassay based on ion-exchanged glass microrods (Conference Presentation)

Simone Berneschi, Cristiano D'Andrea, Ambra Giannetti, Marella De Angelis, Martina Banchelli, Andrea Barucci, Nadia Giovanna Boetti, Stefano Pelli, Francesco Baldini, Roberto Pini, Davide Janner, Diego Pugliese, Daniel Milanese, Paolo Matteini

Proceedings Volume 11361, 113610V (2020) https://doi.org/10.1117/12.2555817

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The well-known enhancement effect of surface-enhanced Raman spectroscopy (SERS) is associated with the presence of metallic nanostructures at the substrate surface. Different bottom-up and top-down processes have been proposed to impart the substrate with such a nanostructured layer. The former approaches are low cost but may suffer from reusability and stability. The latter strategies are expensive, time consuming and require special equipment that complicate the fabrication process. Here, we present the possibility to obtain stable and reusable SERS substrates by a low-cost silver-sodium ion-exchange process in soda-lime glass microrods. The microrods were obtained by cutting the tip of the ion-exchanged soda-lime fiber, resulting in disks of about few millimeters in length and one hundred microns in diameter. A thermal annealing post-process was applied to trigger the reduction of Ag+ ions into nanoparticles (AgNPs) within the ion-exchanged glass microrods. Afterwards, ion-exchange and thermal treatments were carefully tuned to assure the presence of silver NPs exposed on the surface of the microrods, without using any chemical etching. An AFM analysis confirmed the presence of AgNPs with size of tens of nm on the surface of the fiber probe. A SERS affinity bioassay was developed on the probe with the final aim of detecting microRNA fragments acting as biomarkers of different diseases. Specifically a DNA hybridization assay was built up by anchoring a molecular beacon containing a Raman tag on the Ag surface via thiol chemistry. Initial SERS experiments confirmed the presence of the beacon on the NPs embedded on the microrods surface, as monitored by detecting main spectral bands ascribed to the oligonucleotide chain. Finally, the ability of the platform to interact with the target microRNA sequence was assessed. The analysis was repeated on a number of miRNA sequences differing from the target to evaluate the specificity of the proposed assay.

Proceedings Article | 19 February 2020 Paper

New materials for laser welding of connective tissue and controlled release of antimicrobial principles

Fulvio Ratto, Annalisa Aluigi, Sonia Centi, Alessio Milanesi, Boris Khlebtsov, Nikolai Khlebtsov, Vania Delfino, Carmela Calonico, Antonella Lo Nostro, Giada Magni, Claudia Borri, Lucia Cavigli, Paolo Matteini, Roberto Pini, Francesca Rossi

Proceedings Volume 11223, 112230S (2020) https://doi.org/10.1117/12.2545141

KEYWORDS: Laser welding, Connective tissue, Gold, Nanorods, Indocyanine green, Plasmonics, Nanoparticles, Adhesives, Wound healing, Optical fibers

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Proceedings Article | 17 February 2020 Paper

Preliminary ex vivo and in vivo evaluation of laser bonding in dura mater

Roberto Colasanti, Maurizio Iacoangeli, Alessandra Marini, Denis Aiudi, Erika Carrassi, Alessandro Di Rienzo, Massimo Scerrati, Fiorenza Orlando, Mauro Provinciali, Luca Giannoni, Laura Pieri, Filippo Fagnani, Stefano Dallari, Giada Magni, Paolo Matteini, Fulvio Ratto, Roberto Pini, Francesca Rossi

Proceedings Volume 11225, 112250G (2020) https://doi.org/10.1117/12.2543750

KEYWORDS: Laser bonding, In vivo imaging, Tissues, Laser tissue interaction, Surgery, Wound healing, Semiconductor lasers, Animal model studies, Laser welding, Collagen

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Proceedings Article | 22 July 2019 Paper

Human keloid cultured fibroblasts irradiated with blue LED light: evidence from an in vitro study

Giada Magni, Martina Banchelli, Federica Cherchi, Elisabetta Coppi, Marco Fraccalvieri, Anna Maria Pugliese, Felicita Pedata, Antongiulio Mangia, Stefano Gasperini, Francesco Pavone, Duccio Rossi Degl'Innocenti, Lorenzo Targetti, Roberto Pini, Paolo Matteini, Francesca Rossi

Proceedings Volume 11079, 110790V (2019) https://doi.org/10.1117/12.2527084

KEYWORDS: Blue light emitting diodes, Raman spectroscopy, Tissues, In vitro testing, Therapeutics, Light emitting diodes, Wound healing, Skin

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Proceedings Article | 27 February 2019 Presentation + Paper

Fiber-enhanced Raman spectroscopy as a tool for an early detection of Alzheimer's disease biomarkers

P. Eravuchira, M. Banchelli, C. D'Andrea, M. De Angelis, P. Matteini, I. Gannot

Proceedings Volume 10872, 1087211 (2019) https://doi.org/10.1117/12.2516545

KEYWORDS: Raman spectroscopy, Alzheimer's disease, Spectroscopy, Raman scattering, Photonic crystal fibers, Liquids

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Proceedings Article | 13 February 2018 Paper

Plasmon-enhanced Raman detection of body-fluid components

Paolo Matteini, Martina Banchelli, Marella De Angelis, Cristiano D'Andrea, Roberto Pini

Proceedings Volume 10488, 104880W (2018) https://doi.org/10.1117/12.2295086

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Molecules, Plasmonics, Nanoparticles, Molecular assembly, Biological research, Biomedical optics

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Proceedings Article | 22 April 2016 Paper

Graphene oxide / plasmon nanoparticles bilayers for optimized SERS detection

M. Banchelli, M. de Angelis, R. Pini, B. Tiribilli, G. Caminati, P. Matteini

Proceedings Volume 9725, 97250Q (2016) https://doi.org/10.1117/12.2214623

KEYWORDS: Surface enhanced Raman spectroscopy, Graphene, Nanoparticles, Oxides, Silver, Plasmons, Plasmonics, Biosensing, Nanocomposites, Modulation, Magnesium, Raman spectroscopy, Adsorption, Coating, Molecules

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Proceedings Article | 7 March 2016 Presentation + Paper

Investigation on laser-assisted tissue repair with NIR millisecond-long light pulses and Indocyanine Green-biopolymeric patches

Paolo Matteini, Martina Banchelli, Maximilien Cottat, Iacopo Osticioli, Marella de Angelis, Francesca Rossi, Roberto Pini

Proceedings Volume 9702, 97020A (2016) https://doi.org/10.1117/12.2214621

KEYWORDS: Surgery, Laser welding, Near infrared, Photothermal effect, Optical fibers, Arteries, Laser tissue interaction, Collagen, Raman spectroscopy, Tissue optics, Tissues

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Proceedings Article | 11 March 2015 Paper

The influence of cellular uptake on the photostability and photoacoustic conversion efficiency of gold nanorods

Lucia Cavigli, Fulvio Ratto, Francesca Tatini, Paolo Matteini, Alberto Cini, Ilaria Giovannelli, Marella de Angelis, Francesca Rossi, Sonia Centi, Roberto Pini

Proceedings Volume 9323, 932346 (2015) https://doi.org/10.1117/12.2077632

KEYWORDS: Photoacoustic spectroscopy, Gold, Biomedical optics, Particles, Plasmons, Near infrared, Absorbance, Tissue optics, Transmission electron microscopy, Nanorods

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Proceedings Article | 11 March 2015 Paper

Bidimensional assemblies of nonspherical gold nanoparticles for SERS analysis of biomolecules

Paolo Matteini, Marella de Angelis, Lorenzo Ulivi, Sonia Centi, Roberto Pini

Proceedings Volume 9340, 93400S (2015) https://doi.org/10.1117/12.2078659

KEYWORDS: Surface enhanced Raman spectroscopy, Proteins, Nanoparticles, Gold, Biological research, Particles, Nanolithography, Nanostructures, Interfaces, Analytical research

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Proceedings Article | 8 May 2014 Paper

Laser bonding with ICG-infused chitosan patches: preliminary experiences in suine dura mater and vocal folds

Francesca Rossi, Paolo Matteini, Fulvio Ratto, Roberto Pini, Maurizio Iacoangeli, Luca Giannoni, Damiano Fortuna, Emiliano Di Cicco, Sylwia Corbara, Stefano Dallari

Proceedings Volume 9129, 91292L (2014) https://doi.org/10.1117/12.2051487

KEYWORDS: Tissues, Laser bonding, Semiconductor lasers, Wound healing, Surgery, Laser therapeutics, Carbon dioxide lasers, Laser welding, Matrices, Chromophores

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Laser bonding is a promising minimally invasive approach, emerging as a valid alternative to conventional suturing techniques. It shows widely demonstrated advantages in wound treatment: immediate closuring effect, minimal inflammatory response and scar formation, reduced healing time. This laser based technique can overcome the difficulties in working through narrow surgical corridors (e.g. the modern “key-hole” surgery as well as the endoscopy setting) or in thin tissues that are impossible to treat with staples and/or stitches. We recently proposed the use of chitosan matrices, stained with conventional chromophores, to be used in laser bonding of vascular tissue. In this work we propose the same procedure to perform laser bonding of vocal folds and dura mater repair. Laser bonding of vocal folds is proposed to avoid the development of adhesions (synechiae), after conventional or CO2 laser surgery. Laser bonding application in neurosurgery is proposed for the treatment of dural defects being the Cerebro Spinal Fluid leaks still a major issue.
Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice.
In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in depth.

Proceedings Article | 14 June 2013 Paper

Photoacoustic stability of gold nanorods embedded in biopolymeric scaffolds

Lucia Cavigli, Marella De Angelis, Fulvio Ratto, Paolo Matteini, Francesca Rossi, Francesca Tatini, Sonia Centi, Roberto Pini

Proceedings Volume 8800, 88000E (2013) https://doi.org/10.1117/12.2032546

KEYWORDS: Photoacoustic spectroscopy, Biomedical optics, Gold, Particles, Absorption, Plasmons, Biomimetics, Nanoparticles, Tissue optics, Nanorods

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Proceedings Article | 4 March 2013 Paper

Optimization of the photoacoustic conversion of gold nanorods embedded in biopolymeric scaffolds

Lucia Cavigli, Marella De Angelis, Fulvio Ratto, Paolo Matteini, Francesca Rossi, Sonia Centi, Roberto Pini

Proceedings Volume 8581, 85810Z (2013) https://doi.org/10.1117/12.2003173

KEYWORDS: Photoacoustic spectroscopy, Gold, Biomedical optics, Particles, Absorption, Plasmons, Tissue optics, Biomimetics, Thermography, Nanorods

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SPIE Journal Paper | 19 January 2012 Open Access

Emerging concepts of laser-activated nanoparticles for tissue bonding

Paolo Matteini, Fulvio Ratto, Francesca Rossi, Roberto Pini

JBO, Vol. 17, Issue 1, 010701, (January 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.1.010701

KEYWORDS: Gold, Nanoparticles, Laser tissue interaction, Laser bonding, Tissue optics, Tissues, Absorption, Near infrared, Semiconductor lasers, Nanorods

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Proceedings Article | 2 June 2011 Paper

In vivo laser assisted end-to-end anastomosis with ICG-infused chitosan patches

Francesca Rossi, Paolo Matteini, Giuseppe Esposito, Alba Scerrati, Alessio Albanese, Alfredo Puca, Giulio Maira, Giacomo Rossi, Roberto Pini

Proceedings Volume 8092, 809212 (2011) https://doi.org/10.1117/12.889800

KEYWORDS: Laser welding, In vivo imaging, Semiconductor lasers, Arteries, Laser tissue interaction, Patents, Wound healing, Simulation of CCA and DLA aggregates, Optical fibers, Laser vision correction

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Proceedings Article | 18 February 2011 Paper

In vivo experimental study on laser welded ICG-loaded chitosan patches for vessel repair

Francesca Rossi, Paolo Matteini, Giuseppe Esposito, Alessio Albanese, Alfredo Puca, Giulio Maira, Giacomo Rossi, Roberto Pini

Proceedings Volume 7883, 78833M (2011) https://doi.org/10.1117/12.874460

KEYWORDS: Laser welding, Tissues, Arteries, Wound healing, In vivo imaging, Laser tissue interaction, Semiconductor lasers, Chromophores, Patents, Surgery

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