Ms. Saskia C. Kruitwagen Profile

Saskia C. Kruitwagen

at Univ Twente

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Publications (7)

Proceedings Article | 7 March 2022 Poster

Insights from healthy human studies with a photoacoustic tomography system for breast imaging

Rianne Bulthuis, Maura Dantuma, Saskia Kruitwagen, Frédérique P. van Gameren, Felix Lucka, Bruno De Santi, Saskia Aarnink, Lioe-Fee de Geus-Oei, Ben Cox, Srirang Manohar, Ashkan Javaherian

Proceedings Volume PC11960, PC119600X (2022) https://doi.org/10.1117/12.2609529

KEYWORDS: Breast, Photoacoustic tomography, Imaging systems, Breast imaging, Skin, Visibility, Photoacoustic spectroscopy, Tomography, Image analysis, Image acquisition

Proceedings Article | 9 December 2021 Paper

Imaging results from a semi-anthropomorphic photoacoustic-ultrasound breast phantom carrying blood vessels

Maura Dantuma, Saskia Kruitwagen, Javier Ortega Julia, Rutger Pompe van Meerdervoort, Srirang Manohar

Proceedings Volume 11923, 1192310 (2021) https://doi.org/10.1117/12.2615981

KEYWORDS: Blood, Breast, Imaging systems, Oxygen, Blood vessels, Tissues, Photoacoustic spectroscopy, X-ray computed tomography, Magnetic resonance imaging, Data modeling

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Proceedings Article | 9 December 2021 Paper

Quantification of total haemoglobin concentrations in human whole-blood based on the optical density with spectroscopic optical coherence tomography

Carlos Cuartas-Vélez, Colin Veenstra, Saskia Kruitwagen, Wilma Petersen, Nienke Bosschaart

Proceedings Volume 11924, 119240R (2021) https://doi.org/10.1117/12.2616058

KEYWORDS: Blood, Spectroscopy, Mirrors, Optical spectroscopy, Optical coherence tomography, Data modeling, Absorbance, Data acquisition, Oxygen, Optical filtering

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SPIE Journal Paper | 9 December 2021 Open Access

Suite of 3D test objects for performance assessment of hybrid photoacoustic-ultrasound breast imaging systems

Maura Dantuma, Saskia Kruitwagen, Marlies Weggemans, Tim J. P. op't Root, Srirang Manohar

JBO, Vol. 27, Issue 07, 074709, (December 2021) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074709

KEYWORDS: Imaging systems, Breast, Spatial resolution, Tissue optics, Acoustics, Sensors, Blood, 3D metrology, 3D image processing, Image quality

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Significance: During the development and early testing phases of new photoacoustic (PA) breast imaging systems, several choices need to be made in aspects of system design and measurement sequences. Decision-making can be complex for state-of-the-art systems such as 3D hybrid photoacoustic-ultrasound (PA-US) breast imagers intended for multispectral quantitative imaging. These systems have a large set of design choices and system settings that affect imaging performance in different ways and often require trade-offs. Decisions have to be made carefully as they can strongly influence the imaging performance. Aim: A systematic approach to assess the influence of various choices on the imaging performance in carefully controlled laboratory situations is crucial before starting with human studies. Test objects and phantoms are used for first imaging studies, but most reported structures have a 2D geometry and are not suitable to assess all the image quality characteristics (IQCs) of 3D hybrid PA-US systems. Approach: Our work introduces a suite of five test objects designed for hybrid PA-US systems with a 3D detection aperture. We present the test object designs and production protocols and explain how they can be used to study various performance measures. To demonstrate the utility of the developed objects, measurements are made with an existing tomographic PA system. Results: Two test objects were developed for measurements of the US detectors’ impulse responses and light distribution on the breast surface. Three others were developed to assess image quality and quantitative accuracy of the PA and US modes. Three of the five objects were imaged to demonstrate their use. Conclusions: The developed test objects allow one to study influences of various choices in design and system settings. With this, IQCs can be assessed as a function of measurement sequence settings for the PA and US modes in a controlled way. Systematic studies and measurements using these objects will help to optimize various system settings and measurement protocols in laboratory situations before embarking on human studies.

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SPIE Journal Paper | 16 March 2021 Open Access

Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom

Maura Dantuma, Saskia Kruitwagen, Javier Ortega Julia, Rutger Pompe van Meerdervoort, Srirang Manohar

JBO, Vol. 26, Issue 03, 036003, (March 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.3.036003

KEYWORDS: Blood, Breast, Tissues, Tumors, Absorption, Tissue optics, Acoustics, Connectors, Imaging systems, Optical properties

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Significance: Recovering accurate oxygenation estimations in the breast with quantitative photoacoustic tomography (QPAT) is not straightforward. Accurate light fluence models are required, but the unknown ground truth of the breast makes it difficult to validate them. Phantoms are often used for the validation, but most reported phantoms have a simple architecture. Fluence models developed in these simplistic objects are not accurate for application on the complex tissues of the breast. Aim: We present a sophisticated breast phantom platform for photoacoustic (PA) and ultrasound (US) imaging in general, and specifically for QPAT. The breast phantom is semi-anthropomorphic in distribution of optical and acoustic properties and contains wall-less channels with blood. Approach: 3D printing approaches are used to develop the solid 3D breast phantom from custom polyvinyl chloride plastisol formulations and additives for replicating the tissue optical and acoustic properties. A flow circuit was developed to flush the channels with bovine blood with a controlled oxygen saturation level. To showcase the phantom’s functionality, PA measurements were performed on the phantom with two oxygenation levels. Image reconstructions with and without fluence compensation from Monte Carlo simulations were analyzed for the accuracy of oxygen saturation estimations. Results: We present design aspects of the phantom, demonstrate how it is developed, and present its breast-like appearance in PA and US imaging. The oxygen saturations were estimated in two regions of interest with and without using the fluence models. The fluence compensation positively influenced the SO2 estimations in all cases and confirmed that highly accurate fluence models are required to minimize estimation errors. Conclusions: This phantom allows studies to be performed in PA in carefully controlled laboratory settings to validate approaches to recover both qualitative and quantitative features sought after in in-vivo studies. We believe that testing with phantoms of this complexity can streamline the transition of new PA technologies from the laboratory to studies in the clinic.

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Proceedings Article | 20 April 2020 Presentation

Test-objects and phantoms for characterization and optimization of hybrid 3D PA-US systems (Conference Presentation)

Maura Dantuma, Javier Ortega Julia, Saskia Kruitwagen, Damien Gasteau, Srirang Manohar

Proceedings Volume 11240, 112401C (2020) https://doi.org/10.1117/12.2543410

KEYWORDS: Blood, Image restoration, Photoacoustic imaging, Blood vessels, Breast, Reconstruction algorithms, Breast cancer, Visualization, Diagnostics, Ultrasonography

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Proceedings Article | 13 March 2019 Presentation

Quantificiation of hemoglobin concentrations in whole blood by visible-light spectroscopic optical coherence tomography (Conference Presentation)

Colin Veenstra, Saskia Kruitwagen, Dafne Groener, Wilma Petersen, Wiendelt Steenbergen, Nienke Bosschaart

Proceedings Volume 10885, 1088505 (2019) https://doi.org/10.1117/12.2509866

KEYWORDS: Blood, Optical spectroscopy, Spectroscopy, Optical coherence tomography, Signal attenuation, Tissue optics, Oxygen, Heart, Failure analysis, Absorption

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