Dr. André Conjusteau Profile

Dr. André Conjusteau

CEO at Pinami LLC

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Publications (35)

Proceedings Article | 11 March 2015 Paper

Paper

Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research

Sergey Ermilov, Richard Su, Andre Conjusteau, Tanmayi Oruganti, Kun Wang, Fatima Anis, Mark Anastasio, Alexander Oraevsky

Proceedings Volume 9323, 93230N (2015) https://doi.org/10.1117/12.2085028

KEYWORDS: Imaging systems, Ultrasonography, 3D image processing, Absorption, Acoustics, Transducers, Laser systems engineering, Reconstruction algorithms, Kidney, Tomography

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Proceedings Article | 3 March 2014 Paper

Paper

Dual modality optoacoustic and laser ultrasound endoscopy system

Dmitri Tsyboulski, André Conjusteau, Alexander Oraevsky

Proceedings Volume 8943, 89432S (2014) https://doi.org/10.1117/12.2044424

KEYWORDS: Ultrasonography, Endoscopy, Reflectors, Transducers, Signal detection, Imaging systems, Acoustics, Cancer, Tumors, Esophagus

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Proceedings Article | 3 March 2014 Paper

Paper

Temperature dependence of Grüneisen parameter in optically absorbing solutions measured by 2D optoacoustic imaging

Elena Petrova, Sergey Ermilov, Richard Su, Vyacheslav Nadvoretskiy, André Conjusteau, Alexander Oraevsky

Proceedings Volume 8943, 89430S (2014) https://doi.org/10.1117/12.2039949

KEYWORDS: Temperature metrology, Nickel, Absorbance, Thermodynamics, Carbon, Thermography, Liquids, Optical testing, Fiber lasers, Laser optics

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Proceedings Article | 3 March 2014 Paper

Paper

Investigation of the adjoint-state method for ultrasound computed tomography: a numerical and experimental study

Fatima Anis, Yang Lou, André Conjusteau, Richard Su, Tanmayi Oruganti, Sergey Ermilov, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 8943, 894337 (2014) https://doi.org/10.1117/12.2042636

KEYWORDS: Ultrasonography, Reconstruction algorithms, Computed tomography, Imaging systems, Breast imaging, Biomedical optics, Transducers, CT reconstruction, Image restoration, Tomography

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Proceedings Article | 3 March 2014 Paper

Paper

3D laser optoacoustic ultrasonic imaging system for research in mice (LOUIS-3DM)

Sergey Ermilov, Richard Su, Andre Conjusteau, Vassili Ivanov, Vyacheslav Nadvoretskiy, Tanmayi Oruganti, Pratik Talole, Fatima Anis, Mark Anastasio, Alexander Oraevsky

Proceedings Volume 8943, 89430J (2014) https://doi.org/10.1117/12.2044817

KEYWORDS: Ultrasonography, Imaging systems, Acoustics, 3D image processing, Transducers, Receivers, Tomography, Visualization, Reconstruction algorithms, Prototyping

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Proceedings Article | 3 March 2014 Paper

Paper

Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo, Paul Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene Zubarev, Alexander Oraevsky

Proceedings Volume 8943, 894368 (2014) https://doi.org/10.1117/12.2044628

KEYWORDS: Bacteria, Gold, Plasmons, Imaging systems, Absorbance, Scanning electron microscopy, Absorption, Optical properties, Calibration, Nanorods

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Proceedings Article | 4 March 2013 Paper

Paper

Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Jason Zalev, Bryan Clingman, Remie Smith, Don Herzog, Tom Miller, A. Thomas Stavros, Sergey Ermilov, André Conjusteau, Dmitri Tsyboulski, Alexander Oraevsky, Kenneth Kist, N. Dornbluth, Pamela Otto

Proceedings Volume 8581, 858103 (2013) https://doi.org/10.1117/12.2009112

KEYWORDS: Ultrasonography, Tumors, Breast, Tissues, Blood, Biopsy, Cancer, Tissue optics, Absorption, Diagnostics

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Proceedings Article | 4 March 2013 Paper

Paper

Image reconstruction and system optimization for three-dimensional speed of sound tomography using laser-induced ultrasound

Fatima Anis, Richard Su, Vyacheslav Nadvoretsky, André Conjusteau, Sergey Ermilov, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 8581, 85814T (2013) https://doi.org/10.1117/12.2008813

KEYWORDS: Imaging systems, Ultrasonography, Transducers, 3D image processing, Tomography, Image restoration, Receivers, Reconstruction algorithms, 3D modeling, Biomedical optics

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Proceedings Article | 4 March 2013 Paper

Paper

3D laser optoacoustic ultrasonic imaging system for preclinical research

Sergey Ermilov, André Conjusteau, Travis Hernandez, Richard Su, Vyacheslav Nadvoretskiy, Dmitri Tsyboulski, Fatima Anis, Mark Anastasio, Alexander Oraevsky

Proceedings Volume 8581, 85810N (2013) https://doi.org/10.1117/12.2008811

KEYWORDS: Ultrasonography, Imaging systems, Acoustics, 3D image processing, Tomography, Visualization, Signal attenuation, 3D modeling, Ultrasound tomography, Pre-clinical research

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Proceedings Article | 4 March 2013 Paper

Paper

Generation of wide-directivity broadband ultrasound by short laser pulses

André Conjusteau, Vyacheslav Nadvoretskiy, Sergey Ermilov, Alexander Oraevsky

Proceedings Volume 8581, 85814U (2013) https://doi.org/10.1117/12.2008869

KEYWORDS: Ultrasonography, Spherical lenses, Acoustics, Detector arrays, Wavefronts, Imaging systems, Neodymium, Pulsed laser operation, Sensors, 3D image processing

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Proceedings Article | 23 February 2012 Paper

Paper

PEG-coated gold nanorod monoclonal antibody conjugates in preclinical research with optoacoustic tomography, photothermal therapy, and sensing

Anton Liopo, André Conjusteau, Alexander Oraevsky

Proceedings Volume 8223, 822344 (2012) https://doi.org/10.1117/12.910838

KEYWORDS: Gold, Monoclonal antibodies, Tumors, Leukemia, Liver, Receptors, Pre-clinical research, Tomography, Nanoparticles, Nanorods

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Proceedings Article | 23 February 2012 Paper

Paper

Optoacoustic microscopy system based on an off-axis parabolic reflector

Dmitri Tsyboulski, André Conjusteau, Alexander Oraevsky

Proceedings Volume 8223, 82230Z (2012) https://doi.org/10.1117/12.911015

KEYWORDS: Transducers, Reflectors, Microscopy, Signal detection, Ultrasonography, Mirrors, Imaging systems, Image resolution, Point spread functions, Off axis mirrors

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Proceedings Article | 11 April 2011 Paper

Paper

Optoacoustic imaging system with improved collection efficiency

Dmitri Tsyboulski, André Conjusteau, Sergey Ermilov, Hans-Peter Brecht, Anton Liopo, Richard Su, Vyacheslav Nadvoretsky, Alexander Oraevsky

Proceedings Volume 7899, 78991D (2011) https://doi.org/10.1117/12.877723

KEYWORDS: Transducers, Ultrasonography, Wavefronts, Microscopy, Reflectors, Mirrors, Acoustics, Signal attenuation, Imaging systems, Spherical lenses

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Proceedings Article | 28 February 2011 Paper

Paper

Optoacoustic sensor for nanoparticle linked immunosorbent assay (NanoLISA)

André Conjusteau, Anton Liopo, Dmitri Tsyboulski, Sergey Ermilov, William Elliott, Norman Barsalou, Saher Maswadi, Randolph Glickman, Alexander Oraevsky

Proceedings Volume 7899, 789910 (2011) https://doi.org/10.1117/12.879401

KEYWORDS: Gold, Sensors, Nanoparticles, Biosensors, Target detection, Ferroelectric polymers, Pulsed laser operation, Acoustics, Signal to noise ratio, Nanorods

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Proceedings Article | 28 February 2011 Paper

Paper

Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates

Anton Liopo, André Conjusteau, Marina Konopleva, Michael Andreeff, Alexander Oraevsky

Proceedings Volume 7897, 789710 (2011) https://doi.org/10.1117/12.878802

KEYWORDS: Leukemia, Gold, Proteins, Particles, Cell death, Plasmons, Laser therapeutics, Laser applications, Nanoparticles, Nanorods

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Optoacoustic imaging of the prostate: development toward image-guided biopsy

Mohammad Yaseen, Sergey Ermilov, Hans-Peter Brecht, Richard Su, André Conjusteau, Matthew Fronheiser, Brent Bell, Massoud Motamedi, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021310, (March 2010) https://doi.org/10.1117/12.10.1117/1.3333548

KEYWORDS: Prostate, Tissues, Acoustics, Tissue optics, Signal detection, Biopsy, In vivo imaging, Imaging systems, Tumors, Signal processing

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature

Matthew Fronheiser, Sergey Ermilov, Hans-Peter Brecht, André Conjusteau, Richard Su, Ketan Mehta, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021305, (March 2010) https://doi.org/10.1117/12.10.1117/1.3370336

KEYWORDS: Arteries, Veins, Blood vessels, Visualization, Imaging systems, Video, Ultrasonography, Real time imaging, Skin, Blood circulation

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Proceedings Article | 26 February 2010 Paper

Paper

In vivo 3D visualization of peripheral circulatory system using linear optoacoustic array

Sergey Ermilov, Hans-Peter Brecht, Matthew Fronheiser, Vyacheslav Nadvoretsky, Richard Su, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 7564, 756422 (2010) https://doi.org/10.1117/12.847933

KEYWORDS: Blood vessels, Arteries, Computer simulations, Veins, Absorption, Skin, 3D image processing, Blood, In vivo imaging, Laser beam diagnostics

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Proceedings Article | 24 February 2010 Paper

Paper

Real-time optoacoustic imaging of breast cancer using an interleaved two laser imaging system coregistered with ultrasound

Sergey Ermilov, Matthew Fronheiser, Vyacheslav Nadvoretsky, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7564, 75641W (2010) https://doi.org/10.1117/12.847946

KEYWORDS: Tumors, Breast, Breast cancer, Ultrasonics, Imaging systems, Ultrasonography, Blood vessels, Mammography, Deconvolution, Visualization

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Proceedings Article | 24 February 2010 Paper

Paper

Toward functional imaging using the optoacoustic 3D whole-body tomography system

R. Su, H.-P. Brecht, S. Ermilov, V. Nadvoretsky, A. Conjusteau, A. Oraevsky

Proceedings Volume 7564, 756423 (2010) https://doi.org/10.1117/12.847044

KEYWORDS: Absorption, Nickel, Tomography, Imaging systems, 3D image processing, Scattering, Signal processing, Wavelets, Functional imaging, Filtering (signal processing)

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Proceedings Article | 24 February 2010 Paper

Paper

Effects of optical energy distribution on the generation of acoustic plane waves

André Conjusteau, Sergey Ermilov, Hans-Peter Brecht, Alexander Oraevsky

Proceedings Volume 7564, 75641L (2010) https://doi.org/10.1117/12.846992

KEYWORDS: Acoustics, Pulsed laser operation, Sensors, Transducers, Signal detection, Signal attenuation, Ultrasonics, Wavefronts, Laser energy, Absorption

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SPIE Journal Paper | 1 November 2009 Open Access

Open Access

Whole-body three-dimensional optoacoustic tomography system for small animals

Hans-Peter Brecht, Richard Su, Matthew Fronheiser, Sergey Ermilov, André Conjusteau, Alexander Oraevsky

JBO, Vol. 14, Issue 06, 064007, (November 2009) https://doi.org/10.1117/12.10.1117/1.3259361

KEYWORDS: Tomography, Transducers, 3D image processing, Imaging systems, Opacity, Visualization, Video, Veins, Tissue optics, Kidney

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SPIE Journal Paper | 1 March 2009 Open Access

Open Access

Laser optoacoustic imaging system for detection of breast cancer

Sergey Ermilov, Tuenchit Khamapirad, André Conjusteau, Morton Leonard, Ron Lacewell, Ketan Mehta, Tom Miller, Alexander Oraevsky

JBO, Vol. 14, Issue 02, 024007, (March 2009) https://doi.org/10.1117/12.10.1117/1.3086616

KEYWORDS: Tumors, Breast, Transducers, Acoustics, Imaging systems, Tissue optics, Breast cancer, Mammography, Ultrasonography, Signal detection

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Proceedings Article | 25 February 2009 Paper

Paper

Detection of gold-nanorod targeted pathogens using optical and piezoelectric optoacoustic sensors: comparative study

André Conjusteau, Saher Maswadi, Sergey Ermilov, Hans-Peter Brecht, Norman Barsalou, Randolph Glickman, Alexander Oraevsky

Proceedings Volume 7177, 71771P (2009) https://doi.org/10.1117/12.813434

KEYWORDS: Transducers, Acoustics, Sensors, Laser beam diagnostics, Gold, Signal detection, Signal generators, Target detection, Pathogens, Nanorods

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Proceedings Article | 25 February 2009 Paper

Paper

Characterization of optoacoustic transducers through the analysis of angular-dependent frequency response

André Conjusteau, Sergey Ermilov, Richard Su, Hans-Peter Brecht, Matthew Fronheiser, Alexander Oraevsky

Proceedings Volume 7177, 71770U (2009) https://doi.org/10.1117/12.812339

KEYWORDS: Transducers, Acoustics, Sensors, Calibration, Wavefronts, Ultrasonography, Signal attenuation, Pulsed laser operation, Image restoration, Signal to noise ratio

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Proceedings Article | 25 February 2009 Paper

Paper

Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 7177, 71770E (2009) https://doi.org/10.1117/12.812319

KEYWORDS: Blood vessels, Linear filtering, Wavelets, Tomography, Electronic filtering, Transducers, Imaging systems, Tissue optics, 3D image processing, Alexandrite lasers

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Proceedings Article | 25 February 2009 Paper

Paper

Development of laser optoacoustic and ultrasonic imaging system for breast cancer utilizing handheld array probes

Sergey Ermilov, Matthew Fronheiser, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7177, 717703 (2009) https://doi.org/10.1117/12.812192

KEYWORDS: Breast, Transducers, Tumors, Acoustics, Ultrasonics, Imaging systems, 3D modeling, Signal processing, Visualization, Tissue optics

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We describe two laser optoacoustic imaging systems for breast cancer detection based on arrays of acoustic detectors operated manually in a way similar to standard ultrasonic breast imaging. The systems have the advantages of standard light illumination (regardless of the interrogated part of the breast), the ability to visualize any part of the breast, and convenience in operation. The first system could work in both ultrasonic and optoacoustic mode, and was developed based on a linear ultrasonic breast imaging probe with two parallel rectangular optical bundles. We used it in a pilot clinical study to provide for the first time demonstration that the boundaries of the tumors visualized on the optoacoustic and ultrasonic images matched. Such correlation of coregistered images proves that the objects on both images represented indeed the same tumor. In the optoacoustic mode we were also able to visualize blood vessels located in the neighborhood of the tumor. The second system was proposed as a circular array of acoustic transducers with an axisymmetric laser beam in the center. It was capable of 3D optoacoustic imaging with minimized optoacoustic artifacts caused by the distribution of the absorbed optical energy within the breast tissue. The distribution of optical energy absorbed in the bulk tissue of the breast was removed from the image by implementing the principal component analysis on the measured signals. The computer models for optoacoustic imaging using these two handheld probes were developed. The models included three steps: (1) Monte Carlo simulations of the light distribution within the breast tissue, (2) generation of optoacoustic signals by convolving N-shaped pressure signals from spherical voxels with the shape of individual transducers, and (3) back-projecting processed optoacoustic signals onto spherical surfaces for image reconstruction. Using the developed models we demonstrated the importance of the included spatial impulse response of the optoacoustic imaging system.

Proceedings Article | 28 February 2008 Paper

Paper

Data processing and quasi-3D optoacoustic imaging of tumors in the breast using a linear arc-shaped array of ultrasonic transducers

Sergey Ermilov, Reda Gharieb, Andre Conjusteau, Tom Miller, Ketan Mehta, Alexander Oraevsky

Proceedings Volume 6856, 685603 (2008) https://doi.org/10.1117/12.770321

KEYWORDS: Tumors, Breast, Transducers, Acoustics, Tissues, Wavelets, Signal processing, 3D image processing, Image resolution, Tomography

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Proceedings Article | 28 February 2008 Paper

Paper

Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies

Mohammad Yaseen, H. P.-F. Brecht, Sergey Ermilov, Reda Gharieb, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 6856, 68560T (2008) https://doi.org/10.1117/12.769881

KEYWORDS: Prostate, Tissues, Tumors, Signal detection, Ultrasonography, Transducers, Signal processing, Imaging systems, Ultrasonics, Absorption

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Proceedings Article | 28 February 2008 Paper

Paper

Optoacoustic system for 3D functional and molecular imaging in nude mice

Matthew Fronheiser, Alan Stein, Don Herzog, Scott Thompson, Anton Liopo, Mohammad Eghtedari, Massoud Motamedi, Sergey Ermilov, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Ketan Mehta, Alexander Oraevsky

Proceedings Volume 6856, 68560R (2008) https://doi.org/10.1117/12.770461

KEYWORDS: Imaging systems, Tissues, Tumors, Sensors, Gold, Molecular imaging, Image resolution, 3D image processing, Tissue optics, Nanorods

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A three-dimensional laser optoacoustic imaging system was developed, which combines the advantages of optical spectroscopy and high resolution ultrasonic detection, to produce high contrast maps of optical absorbance in tissues. This system was tested in a nude mouse model of breast cancer and produced tissue images of tumors and vasculature. The imaging can utilize either optical properties of hemoglobin and oxyhemoglobin, which are the main endogenous tissue chromophores in the red and near-infrared spectral ranges, or exogenous contrast agent based on gold nanorods. Visualization of tissue molecules targeted by the contrast agent provides molecular information. Visulization of blood at multiple colors of light provides functional information on blood concentration and oxygen saturation. Optoacoustic imaging, using two or more laser illumination wavelengths, permits an assessment of the angiogenesis-related microvasculature, and thereby, an evaluation of the tumor stage and its metastatic potential. The optoacoustic imaging system was also used to generate molecular images of the malignancy-related receptors induced by the xenografts of BT474 mammary adenocarcinoma cells in nude mice. The development of the latter images was facilitated by the use of an optoacoustic contrast agent that utilizes gold nanorods conjugated to monoclonal antibody raised against HER2/neu antigens. These nanorods possess a very strong optical absorption peak that can be tuned in the near-infrared by changing their aspect ratio. The effective conversion of the optical energy into heat by the gold nanorods, followed by the thermal expansion of the surrounding water, makes these nanoparticles an effective optoacoustic contrast agent. Optical scattering methods and x-ray tomography may also benefit from the application of this contrast agent. Administration of the gold nanorod bioconjugates to mice resulted in an enhanced contrast of breast tumors relative the background of normal tissues in the nude mouse model. The combination of this novel contrast agent and optoacoustic imaging has the potential to become a useful imaging modality, for preclinical research in murine models of cancer and other human diseases.

Proceedings Article | 28 February 2008 Paper

Paper

Photothermolysis by laser-induced microbubbles generated around gold nanorod clusters selectively formed in leukemia cells

Dmitri Lapotko, Ekaterina Lukianova-Hleb, Sergei Zhdanok, Betty Rostro, Rebecca Simonette, Jason Hafner, Marina Konopleva, Michael Andreeff, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 6856, 68560K (2008) https://doi.org/10.1117/12.771660

KEYWORDS: Tumors, Gold, Scattering, Pulsed laser operation, Laser scattering, Nanoparticles, Light scattering, Absorption, Leukemia, Nanorods

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Proceedings Article | 19 February 2007 Paper

Paper

Functionalized gold nanorod particles for molecular optoacoustic imaging

Mohammad Eghtedari, Alexander Oraevsky, Andre Conjusteau, John Copland, Nicholas Kotov, Massoud Motamedi

Proceedings Volume 6437, 64370G (2007) https://doi.org/10.1117/12.716380

KEYWORDS: Gold, Nanoparticles, Signal detection, Laser irradiation, Transducers, In vivo imaging, Absorption, Skin, Cancer, Nanorods

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Proceedings Article | 15 February 2007 Paper

Paper

Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system

Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara McCorvey, Tuenchit Khamapirad, Morton Leonard, Alexander Oraevsky

Proceedings Volume 6437, 643703 (2007) https://doi.org/10.1117/12.714039

KEYWORDS: Transducers, Tumors, Acoustics, Breast, Absorption, Imaging systems, Tissues, Breast cancer, Tomography, Signal processing

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Proceedings Article | 6 March 2006 Paper

Paper

Metallic nanoparticles as optoacoustic contrast agents for medical imaging

Andre Conjusteau, Sergey Ermilov, Dmitri Lapotko, Hongwei Liao, Jason Hafner, Mohammad Eghtedari, Massoud Motamedi, Nicholas Kotov, Alexander Oraevsky

Proceedings Volume 6086, 60860K (2006) https://doi.org/10.1117/12.658065

KEYWORDS: Nanoparticles, Gold, Tumors, Particles, Absorption, Plasmons, Laser damage threshold, Water, Cancer, Nanorods

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Proceedings Article | 6 March 2006 Paper

Paper

128-channel laser optoacoustic imaging system (LOIS-128) for breast cancer diagnostics

Sergey Ermilov, Andre Conjusteau, Ketan Mehta, Ron Lacewell, P. Mark Henrichs, Alexander Oraevsky

Proceedings Volume 6086, 608609 (2006) https://doi.org/10.1117/12.658158

KEYWORDS: Transducers, Absorption, Tumors, Acoustics, Imaging systems, Diagnostics, Signal processing, Signal detection, Tissues, Breast

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Showing 5 of 35 publications

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