Prof. Rongguang Liang Profile

Prof. Rongguang Liang

Professor at Wyant College of Optical Sciences

SPIE Involvement:

Conference Program Committee | Author | Editor | Instructor

Publications (81)

Proceedings Article | 30 September 2024 Presentation + Paper

Measurement of mid-spatial frequencies of diamond turned optics by using dual-mode snapshot interferometry

Neha Khatri, K. Manjunath, Suman Tewary, Wenjun Kang, Rongguang Liang

Proceedings Volume 13134, 131340I (2024) https://doi.org/10.1117/12.3027730

KEYWORDS: Optical surfaces, Diamond turning, Spectral density, Spatial frequencies, Polarized light, Light emitting diodes, Metrology, Laser interferometry, Error analysis, Diamond machining

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Proceedings Article | 13 March 2024 Poster

Scene-aware compressive hyperspectral imaging with spectral tunable light source

Yuanyuan Sun, Rongguang Liang

Proceedings Volume PC12857, PC128571J (2024) https://doi.org/10.1117/12.3005728

KEYWORDS: Light sources and illumination, Hyperspectral imaging, Design and modelling, Biomedical optics, Biomedical applications, Spectral density, RGB color model, Switching, Spectral resolution, Spatial learning

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Proceedings Article | 13 March 2024 Poster

Development of a multimodal intraoral probe for oral cancer

Shaobai Li, Wenjun Kang, Yihan Wang, Hongzhang Ma, Bofan Song, Rongguang Liang

Proceedings Volume PC12834, PC128340S (2024) https://doi.org/10.1117/12.3007491

KEYWORDS: Cancer, Optical coherence tomography, Cancer detection, Autofluorescence, Visualization, Tissues, Scattering, Prototyping, Medicine, In vivo imaging

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Proceedings Article | 13 March 2024 Presentation

Advanced 3D printing of glass micro-optical systems

Zhihan Hong, Piaoran Ye, Yuanyuan Sun, Douglas Loy, Rongguang Liang

Proceedings Volume PC12898, PC128980D (2024) https://doi.org/10.1117/12.3005585

KEYWORDS: Glasses, 3D printing, Manufacturing, Imaging systems, Optics manufacturing, Micro optics, Biological imaging, Astronomical imaging, Waveguides, Shrinkage

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Proceedings Article | 13 March 2024 Presentation

Compact device for intraoperative NIR fluorescence imaging and projection guidance

Tyler Peterson, Rongguang Liang

Proceedings Volume PC12825, PC128250V (2024) https://doi.org/10.1117/12.3008908

KEYWORDS: Near infrared, Fluorescence, Fluorescence imaging, Wearable devices, Tissues, Surgery, Imaging devices, Visualization, Visible radiation, Video

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Proceedings Article | 13 March 2024 Presentation

3D printing glass micro-optics from silsesquioxanes

Piaoran Ye, Zhihan Hong, Rongguang Liang, Douglas Loy

Proceedings Volume PC12898, PC128980C (2024) https://doi.org/10.1117/12.3005589

KEYWORDS: Glasses, Micro optics, 3D printing, Printing, Silica, Shrinkage, Polymers, Nanolithography, Waveguides, Two photon polymerization

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Proceedings Article | 13 March 2024 Presentation

Reliable and trustworthy deep learning algorithm design for oral cancer image analysis

Bofan Song, Dharma KC, Shaobai Li, Chicheng Zhang, Rongguang Liang

Proceedings Volume PC12833, PC1283302 (2024) https://doi.org/10.1117/12.3007296

KEYWORDS: Deep learning, Cancer, Artificial intelligence, Image analysis, Evolutionary algorithms, Design and modelling, Visualization, Visual process modeling, Reliability, Systems modeling

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Proceedings Article | 13 March 2024 Presentation

Large chromatic shift objective for chromatic confocal microscopy

Jiabin Chen, Shuyuan Guan, Shaobai Li, Wenjun Kang, Rongguang Liang

Proceedings Volume PC12848, PC1284804 (2024) https://doi.org/10.1117/12.3007669

KEYWORDS: Colorimetry, Confocal microscopy, Objectives, Biological imaging, Tissues, Tissue optics, Microscopes, Image resolution, Biological samples, Visualization

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Proceedings Article | 13 March 2024 Presentation

Widefield multispectral imaging to evaluate spectral biomarkers associated with oral epithelial dysplasia and squamous cell carcinoma in a hamster buccal model and human clinical samples

Paula Villarreal, Suimin Qiu, Orly Coblens, Tyler Peterson, Bofan Song, Xingde Li, Rongguang Liang, Gracie Vargas

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003202

KEYWORDS: Multispectral imaging, Tumor growth modeling, Statistical modeling, Cancer detection, Tissues, Autofluorescence, Tunable filters, Neck, Liquid crystals, Light emitting diodes

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Proceedings Article | 13 March 2024 Presentation

Benchtop to handheld: characterization and optimization of a ring illuminator/detector in a handheld endogenous fluorescence imaging probe

Paula Villarreal, Tyler Peterson, Bofan Song, Rongguang Liang, Gracie Vargas

Proceedings Volume PC12833, PC1283304 (2024) https://doi.org/10.1117/12.3009704

KEYWORDS: Fluorescence, Light sources and illumination, Imaging systems, Autofluorescence imaging, Signal detection, Light emitting diodes, LED lighting, Fluorescence imaging, Diseases and disorders, Ultraviolet light emitting diodes

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Proceedings Article | 13 March 2024 Presentation + Paper

Comparison of micro-optic systems for close-focus microendoscopic applications

Dominique Galvez, Zhihan Hong, Andrew Rocha, Rongguang Liang, Jennifer Barton

Proceedings Volume 12820, 1282009 (2024) https://doi.org/10.1117/12.3001130

KEYWORDS: Crosstalk, Endoscopes, GRIN lenses, Lenses, Objectives, Optics manufacturing, Fallopian tube, Optical design, Micro optics, Lens design

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Proceedings Article | 13 March 2024 Presentation + Paper

Design of a 1.0mm multiphoton microscopy microendoscope

Zuzana Adams, Zhihan Hong, Lynette Valenzuela, Piaoran Ye, Rongguang Liang, Khanh Kieu, Jennifer Barton

Proceedings Volume 12820, 1282004 (2024) https://doi.org/10.1117/12.3001732

KEYWORDS: Design, Prisms, Endoscopes, Printing, Imaging systems, Zemax, Prototyping, 3D printing, Tissues, Aspheric lenses, Multiphoton microscopy

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Proceedings Article | 13 March 2024 Presentation + Paper

Preclinical evaluation of a handheld theranostic intraoral device for image-guided PDT treatment of pre-malignant and malignant oral lesions

Shakir Khan, Bofan Song, Sergio Farias, Rongguang Liang, Tayyaba Hasan, Jonathan Celli

Proceedings Volume 12823, 1282302 (2024) https://doi.org/10.1117/12.3001825

KEYWORDS: Photodynamic therapy, Tumors, Fluorescence, Tissues, Photobleaching, Fluorescence imaging, Imaging devices, Cancer, Cameras, Mouse models

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Significance: Oral squamous cell carcinoma (OSCC) has an exceptionally high rate of incidence and mortality in India, with 15 cases per 100,000 people and over 70,000 deaths annually. The problem is exacerbated due to insufficient medical infrastructure for widescale screening and oncology care, particularly in rural regions. New technologies are urgently needed to detect oral cancer and provide timely treatment at the point of care. This work draws upon previous development and clinical validation of low-cost hardware for photodynamic therapy (PDT) treatment of oral lesions combined with an intraoral probe for cancer screening, incorporated here into an integrated theranostic device for image-guided PDT. Aim: This study aimed to validate technical performance of a novel hand-held smartphone-coupled intraoral device designed for simultaneous imaging and photodynamic therapy (PDT) of oral lesions. The imaging and PDT light delivery capabilities of the handheld system were evaluated using tissue phantoms containing protoporphyrin IX (PpIX) and a mouse model of OSCC photosensitized using 5-aminolevulinic acid (ALA)-induced PpIX. Approach: The probe’s built-in multi-channel fluorescence and polarized white light imaging capabilities were evaluated using tissue phantoms with TiO₂ and controlled PpIX concentrations. In-vivo testing was performed using mice with subcutaneous TR146 OSCC implants before and after administering ALA, and again to assess photobleaching after light delivery (a total of 100J/cm² at 635nm from the integrated diode laser). Results: Quantification of fluorescence images generated using the device showed that the PpIX signal scaled linearly with concentration, and the extent of photobleaching increased with increasing PDT dose as expected. In murine xenografts, PDT treatment delivered through the intraoral probe reduced tumor volume significantly in comparison to untreated control animals. Conclusion: Our findings demonstrate the effectiveness of a low-cost handheld device for simultaneous quantitative imaging of PpIX fluorescence and image-guided PDT in vivo. The integration of intraoral imaging and image-guided treatment into the same handheld device paves the way for a streamlined approach to cancer screening and early intervention with PDT at the point of care.

Proceedings Article | 4 October 2023 Presentation + Paper

On-machine metrology for diamond turning applications

Wenjun Kang, Yihan Wang, Hongzhang Ma, Daodang Wang, Rongguang Liang

Proceedings Volume 12672, 1267208 (2023) https://doi.org/10.1117/12.2677505

KEYWORDS: Optical surfaces, Diamond turning, Metrology, Light emitting diodes, Diamond, Polymethylmethacrylate, Polarized light, Single point diamond turning, Surface roughness, Reflection

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Proceedings Article | 14 September 2023 Paper

All-reflective, unobscured, freeform microscope for biological research: design and fabrication

Tyler Peterson, Wenjun Kang, Hongzhang Ma, Rongguang Liang

Proceedings Volume 12798, 127980C (2023) https://doi.org/10.1117/12.2691614

KEYWORDS: Objectives, Microscopes, Design and modelling, Biological imaging, Fabrication, Ultraviolet radiation, Infrared imaging, Biological research, Mirrors, Mirror surfaces

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SPIE Journal Paper | 21 July 2023 Open Access

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Shaista Siddiqui, Amjad P. Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen G. Bown, Rongguang Liang, Tayyaba Hasan, Jonathan P. Celli

JBO, Vol. 28, Issue 08, 082809, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.8.082809

KEYWORDS: Photodynamic therapy, Tissues, Image segmentation, Cancer, Oncology, Biomedical optics, Tumors, Imaging systems, Light emitting diodes, Collagen

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SignificanceIndia has one of the highest rates of oral squamous cell carcinoma (OSCC) in the world, with an incidence of 15 per 100,000 and more than 70,000 deaths per year. The problem is exacerbated by a lack of medical infrastructure and routine screening, especially in rural areas. New technologies for oral cancer detection and timely treatment at the point of care are urgently needed.AimOur study aimed to use a hand-held smartphone-coupled intraoral imaging device, previously investigated for autofluorescence (auto-FL) diagnostics adapted here for treatment guidance and monitoring photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence (FL).ApproachA total of 12 patients with 14 buccal mucosal lesions having moderately/well-differentiated micro-invasive OSCC lesions (<2 cm diameter and <5 mm depth) were systemically (in oral solution) administered three doses of 20 mg / kg ALA (total 60 mg / kg). Lesion site PpIX and auto-FL were imaged using the multichannel FL and polarized white-light oral cancer imaging probe before/after ALA administration and after light delivery (fractionated, total 100 J / cm2 of 635 nm red LED light).ResultsThe handheld device was conducive for access to lesion site images in the oral cavity. Segmentation of ratiometric images in which PpIX FL is mapped relative to auto-FL enabled improved demarcation of lesion boundaries relative to PpIX alone. A relative FL (R-value) threshold of 1.4 was found to segment lesion site PpIX production among the patients with mild to severe dysplasia malignancy. The segmented lesion size is well correlated with ultrasound findings. Lesions for which R-value was >1.65 at the time of treatment were associated with successful outcomes.ConclusionThese results indicate the utility of a low-cost, handheld intraoral imaging probe for image-guided PDT and treatment monitoring while also laying the groundwork for an integrated approach, combining cancer screening and treatment with the same hardware.

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Proceedings Article | 17 March 2023 Presentation

Integrating optical diagnostics and PDT: image guided treatment of oral lesions using a handheld multichannel fluorescence probe

Jonathan Celli, Shakir Khan, Rongguang Liang, Tayyaba Hasan, Bilal Hussain, Shahid Ali Siddiqui, Syed Hasan

Proceedings Volume PC12359, PC1235906 (2023) https://doi.org/10.1117/12.2672304

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Proceedings Article | 6 March 2023 Presentation

Analysis considerations for multimodal based approaches in diagnostics

Paula Villarreal, Suimin Qiu, Xingde Li, Rongguang Liang, Gracie Vargas

Proceedings Volume PC12370, PC1237008 (2023) https://doi.org/10.1117/12.2657771

KEYWORDS: Diagnostics, Optical imaging, Multiphoton microscopy, Multimodal imaging, Luminescence, Tumor growth modeling, Tissues, Optical sensing, Cancer

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Proceedings Article | 6 March 2023 Presentation

Design and characterization of handheld multiphoton probe for intraoral imaging

Tyler Peterson, Hongzhang Ma, Paula Villarreal, Xingde Li, Gracie Vargas, Rongguang Liang

Proceedings Volume PC12370, PC1237007 (2023) https://doi.org/10.1117/12.2657635

KEYWORDS: Image resolution, Image quality, Tissues, Prisms, Natural surfaces, Multiphoton fluorescence microscopy, Manufacturing, Design for manufacturability, Cancer, Cameras

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SPIE Journal Paper | 4 January 2023 Open Access

Characterizing close-focus lenses for microendoscopy

Dominique Galvez, Zhihan Hong, Andrew Rocha, John Heusinkveld, Piaoran Ye, Rongguang Liang, Jennifer Barton

JOM, Vol. 3, Issue 01, 011003, (January 2023) https://doi.org/10.1117/12.10.1117/1.JOM.3.1.011003

KEYWORDS: GRIN lenses, Optical systems, Lenses, Optics manufacturing, Optical components, Depth of field, Image resolution, Lens design, Optical microsystems, Glasses

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SPIE Journal Paper | 3 November 2022 Open Access

Exploring uncertainty measures in convolutional neural network for semantic segmentation of oral cancer images

Bofan Song, Shaobai Li, Sumsum Sunny, Keerthi Gurushanth, Pramila Mendonca, Nirza Mukhia, Sanjana Patrick, Tyler Peterson, Shubha Gurudath, Subhashini Raghavan, Imchen Tsusennaro, Shirley Leivon, Trupti Kolur, Vivek Shetty, Vidya Bushan, Rohan Ramesh, Vijay Pillai, Petra Wilder-Smith, Amritha Suresh, Moni Abraham Kuriakose, Praveen Birur, Rongguang Liang

JBO, Vol. 27, Issue 11, 115001, (November 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.11.115001

KEYWORDS: Image segmentation, Cancer, Tumor growth modeling, Performance modeling, Convolution, Instrument modeling, Reliability, Medical research, Inspection, Skin cancer

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SignificanceOral cancer is one of the most prevalent cancers, especially in middle- and low-income countries such as India. Automatic segmentation of oral cancer images can improve the diagnostic workflow, which is a significant task in oral cancer image analysis. Despite the remarkable success of deep-learning networks in medical segmentation, they rarely provide uncertainty quantification for their output.AimWe aim to estimate uncertainty in a deep-learning approach to semantic segmentation of oral cancer images and to improve the accuracy and reliability of predictions.ApproachThis work introduced a UNet-based Bayesian deep-learning (BDL) model to segment potentially malignant and malignant lesion areas in the oral cavity. The model can quantify uncertainty in predictions. We also developed an efficient model that increased the inference speed, which is almost six times smaller and two times faster (inference speed) than the original UNet. The dataset in this study was collected using our customized screening platform and was annotated by oral oncology specialists.ResultsThe proposed approach achieved good segmentation performance as well as good uncertainty estimation performance. In the experiments, we observed an improvement in pixel accuracy and mean intersection over union by removing uncertain pixels. This result reflects that the model provided less accurate predictions in uncertain areas that may need more attention and further inspection. The experiments also showed that with some performance compromises, the efficient model reduced computation time and model size, which expands the potential for implementation on portable devices used in resource-limited settings.ConclusionsOur study demonstrates the UNet-based BDL model not only can perform potentially malignant and malignant oral lesion segmentation, but also can provide informative pixel-level uncertainty estimation. With this extra uncertainty information, the accuracy and reliability of the model’s prediction can be improved.

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Proceedings Article | 4 March 2022 Presentation + Paper

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for ALA PDT monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Mayra BaptistaLopesTeix, Shaista Siddiqui, Amjad Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen Bown, Rongguang Liang, Tayyaba Hasan, Jonathan Celli

Proceedings Volume 11940, 1194004 (2022) https://doi.org/10.1117/12.2609956

KEYWORDS: Photodynamic therapy, Cancer, Image segmentation, Tissues, Oncology, Light emitting diodes, Imaging systems, Visualization

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SPIE Journal Paper | 12 January 2022 Open Access

Interpretable deep learning approach for oral cancer classification using guided attention inference network

Kevin Figueroa, Bofan Song, Sumsum Sunny, Shaobai Li, Keerthi Gurushanth, Pramila Mendonca, Nirza Mukhia, Sanjana Patrick, Shubha Gurudath, Subhashini Raghavan, Imchen Tsusennaro, Shirley Leivon, Trupti Kolur, Vivek Shetty, Vidya Bushan, Rohan Ramesh, Vijay Pillai, Petra Wilder-Smith, Alben Sigamani, Amritha Suresh, Moni Kuriakose, Praveen Birur, Rongguang Liang

JBO, Vol. 27, Issue 01, 015001, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.015001

KEYWORDS: Cancer, Image classification, Network architectures, Visualization, Mining, Lithium, Tongue, Image segmentation, Image processing, Teeth

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Significance: Convolutional neural networks (CNNs) show the potential for automated classification of different cancer lesions. However, their lack of interpretability and explainability makes CNNs less than understandable. Furthermore, CNNs may incorrectly concentrate on other areas surrounding the salient object, rather than the network’s attention focusing directly on the object to be recognized, as the network has no incentive to focus solely on the correct subjects to be detected. This inhibits the reliability of CNNs, especially for biomedical applications. Aim: Develop a deep learning training approach that could provide understandability to its predictions and directly guide the network to concentrate its attention and accurately delineate cancerous regions of the image. Approach: We utilized Selvaraju et al.’s gradient-weighted class activation mapping to inject interpretability and explainability into CNNs. We adopted a two-stage training process with data augmentation techniques and Li et al.’s guided attention inference network (GAIN) to train images captured using our customized mobile oral screening devices. The GAIN architecture consists of three streams of network training: classification stream, attention mining stream, and bounding box stream. By adopting the GAIN training architecture, we jointly optimized the classification and segmentation accuracy of our CNN by treating these attention maps as reliable priors to develop attention maps with more complete and accurate segmentation. Results: The network’s attention map will help us to actively understand what the network is focusing on and looking at during its decision-making process. The results also show that the proposed method could guide the trained neural network to highlight and focus its attention on the correct lesion areas in the images when making a decision, rather than focusing its attention on relevant yet incorrect regions. Conclusions: We demonstrate the effectiveness of our approach for more interpretable and reliable oral potentially malignant lesion and malignant lesion classification.

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SPIE Journal Paper | 23 October 2021 Open Access

Classification of imbalanced oral cancer image data from high-risk population

Bofan Song, Shaobai Li, Sumsum Sunny, Keerthi Gurushanth, Pramila Mendonca, Nirza Mukhia, Sanjana Patrick, Shubha Gurudath, Subhashini Raghavan, Imchen Tsusennaro, Shirley Leivon, Trupti Kolur, Vivek Shetty, Vidya Bushan, Rohan Ramesh, Tyler Peterson, Vijay Pillai, Petra Wilder-Smith, Alben Sigamani, Amritha Suresh, Moni Kuriakose, Praveen Birur, Rongguang Liang

JBO, Vol. 26, Issue 10, 105001, (October 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.10.105001

KEYWORDS: Cancer, Image classification, Data modeling, Tumor growth modeling, Medical imaging, Neural networks, Medical research, Breast cancer, Biomedical optics, Mobile devices

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Proceedings Article | 9 October 2021 Presentation + Paper

Deep-learning-based deflectometry for simultaneous multi-surface measurement of freeform refractive optics

Zhendong Wu, Daodang Wang, Jinchao Dou, Ming Kong, Lihua Lei, Rongguang Liang

Proceedings Volume 11895, 1189504 (2021) https://doi.org/10.1117/12.2601184

KEYWORDS: Wavefronts, Freeform optics, Calibration, Deflectometry, Wavefront reconstruction, Reconstruction algorithms, Optical testing, Neural networks, Tolerancing, Network architectures

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SPIE Journal Paper | 17 August 2021

Measuring large amplitude surface figure error using coordinate metrology

Manal Khreishi, Raymond Ohl, Ryan McClelland, Ron Shiri, Tilak Hewagama, Shahid Aslam, Melville Ulmer, Edgar Canavan, Rongguang Liang

OE, Vol. 60, Issue 08, 084103, (August 2021) https://doi.org/10.1117/12.10.1117/1.OE.60.8.084103

KEYWORDS: Metrology, Mirrors, X-ray optics, Optical engineering, Silicon, Optical testing, Semiconducting wafers, Optical fabrication, Photovoltaics, Interferometry

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SPIE Journal Paper | 23 June 2021 Open Access

Mobile-based oral cancer classification for point-of-care screening

Bofan Song, Sumsum Sunny, Shaobai Li, Keerthi Gurushanth, Pramila Mendonca, Nirza Mukhia, Sanjana Patrick, Shubha Gurudath, Subhashini Raghavan, Tsusennaro Imchen, Shirley Leivon, Trupti Kolur, Vivek Shetty, Vidya Bushan, Rohan Ramesh, Natzem Lima, Vijay Pillai, Petra Wilder-Smith, Alben Sigamani, Amritha Suresh, Moni Kuriakose, Praveen Birur, Rongguang Liang

JBO, Vol. 26, Issue 06, 065003, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.065003

KEYWORDS: Cancer, Image classification, Point-of-care devices, Internet, Convolution, Optimization (mathematics), Image processing, Tumor growth modeling, Light emitting diodes, Gold

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SPIE Journal Paper | 10 April 2021 Open Access

Enabling precision coordinate metrology for universal optical testing and alignment applications (Erratum)

Manal Khreishi, Raymond Ohl, Joseph Howard, Jonathan Papa, Ryan McClelland, Clark Hovis, Theodore Hadjimichael, Patrick Thompson, Kenneth Ranson, Rongguang Liang, Nicolas Gorius

OE, Vol. 60, Issue 04, 049801, (April 2021) https://doi.org/10.1117/12.10.1117/1.OE.60.4.049801

KEYWORDS: Optical testing, Optical alignment, Metrology, Optical engineering, Geometrical optics

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SPIE Journal Paper | 15 March 2021

Enabling precision coordinate metrology for universal optical testing and alignment applications

Manal Khreishi, Raymond Ohl, Joseph Howard, Jonathan Papa, Ryan McClelland, Clark Hovis, Theodore Hadjimichael, Patrick Thompson, Kenneth Ranson, Rongguang Liang, Nicolas Gorius

OE, Vol. 60, Issue 03, 035106, (March 2021) https://doi.org/10.1117/12.10.1117/1.OE.60.3.035106

KEYWORDS: Metrology, Mirrors, Optical testing, Optical alignment, Optical engineering, Interferometry, Optical fabrication, Aspheric lenses, Terbium, Lawrencium

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Proceedings Article | 5 March 2021 Presentation

Use of preclinical models alongside clinical tissues to develop a noninvasive multimodal fluorescence detection approach for oral neoplasia detection

Paula Villarreal, Rahul Pal, Xiaoying Yu, Orly Coblens, Suimin Qiu, Rongguang Liang, Xingde Li, Gracie Vargas

Proceedings Volume 11633, 116330I (2021) https://doi.org/10.1117/12.2591126

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SPIE Journal Paper | 23 June 2020 Open Access

Point-of-care, multispectral, smartphone-based dermascopes for dermal lesion screening and erythema monitoring

Ross Uthoff, Bofan Song, Melody Maarouf, Vivian Shi, Rongguang Liang

JBO, Vol. 25, Issue 06, 066004, (June 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.066004

KEYWORDS: Cameras, Chromophores, Light emitting diodes, Imaging systems, Point-of-care devices, Modulation transfer functions, Image processing, RGB color model, Melanoma, LED lighting

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Proceedings Article | 9 March 2020 Presentation

Dual-modal oral cancer screening platform and automatic classification algorithm for low-resource settings (Conference Presentation)

Bofan Song, Sumsum Sunny, Ross Uthoff, Sanjana Patrick, Amritha Suresh, Trupti Kolur, G. Keerthi, Afarin Anbarani, Petra Wilder-Smith, Moni Kuriakose, Praveen Birur, Jeffrey Rodriguez, Rongguang Liang

Proceedings Volume 11230, 112300V (2020) https://doi.org/10.1117/12.2552213

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Proceedings Article | 19 November 2019 Paper

Instantaneous wavefront measurement based on deflectometry

Zhongming Xie, Daodang Wang, Hanting Gu, Ming Kong, Rongguang Liang, Wentao Zhang

Proceedings Volume 11185, 111850Q (2019) https://doi.org/10.1117/12.2537148

KEYWORDS: Wavefronts, Deflectometry, Calibration, Phase shifts, Cameras, Reconstruction algorithms, Fringe analysis, Composites

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Proceedings Article | 19 November 2019 Paper

Transient microscopic testing method based on deflectometry

Hanting Gu, Daodang Wang, Zhongming Xie, Ming Kong, Rongguang Liang, Wentao Zhang

Proceedings Volume 11185, 111850R (2019) https://doi.org/10.1117/12.2537149

KEYWORDS: Deflectometry, Testing and analysis, Phase shifts, Fringe analysis, Wavefronts, Cameras, Optical testing, Wavefront aberrations, Phase shifting, Phase measurement

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SPIE Journal Paper | 22 October 2019 Open Access

Small form factor, flexible, dual-modality handheld probe for smartphone-based, point-of-care oral and oropharyngeal cancer screening

Ross Uthoff, Bofan Song, Sumsum Sunny, Sanjana Patrick, Amritha Suresh, Trupti Kolur, Keerthi Gurushanth, Kimberly Wooten, Vishal Gupta, Mary Platek, Anurag Singh, Petra Wilder-Smith, Moni Abraham Kuriakose, Praveen Birur, Rongguang Liang

JBO, Vol. 24, Issue 10, 106003, (October 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.10.106003

KEYWORDS: Cameras, Light emitting diodes, Cancer, Silicon, Imaging systems, Head, Modulation transfer functions, Point-of-care devices, Biomedical optics, Optical filters

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Proceedings Article | 9 September 2019 Presentation + Paper

Nautilus Observatory: a space telescope array based on very large aperture ultralight diffractive optical elements

Dániel Apai, Tom Milster, Dae Wook Kim, Alex Bixel, Glenn Schneider, Benjamin Rackham, Rongguang Liang, Jonathan Arenberg

Proceedings Volume 11116, 1111608 (2019) https://doi.org/10.1117/12.2529428

KEYWORDS: Telescopes, Lenses, Space telescopes, Planets, Observatories, Astrophysics, Optical fabrication, Exoplanets, Space observatories, Earth's atmosphere

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Proceedings Article | 8 July 2019 Paper

Laser modulation simulation of micro-crack morphology evolution during chemical etching

Zhi Chen, Huapan Xiao, Zhibin Li, Na Yu, Hairong Wang, Rongguang Liang

Proceedings Volume 11063, 110631H (2019) https://doi.org/10.1117/12.2540729

KEYWORDS: Modulation, Glasses, Wet etching, Optical components, Etching, Optical simulations, Laser induced damage, Polishing, Finite-difference time-domain method

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Proceedings Article | 13 May 2019 Presentation

Compact snapshot freefrom null testing with adaptive optics (Conference Presentation)

Xiaobo Tian, Heejoo Choi, Alexander Sohn, Yu Zhang, Oliver Joshua Spires, Dae Wook Kim, Rongguang Liang

Proceedings Volume 10991, 109910Q (2019) https://doi.org/10.1117/12.2518789

KEYWORDS: Deformable mirrors, Optical testing, Adaptive optics, Algorithm development, Wavefronts, Interferometry, Stochastic processes, Phase measurement, Deflectometry

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Proceedings Article | 13 May 2019 Presentation

Dual-mode snapshot interferometric system for on-machine metrology (Conference Presentation)

Xiaobo Tian, Alexander Sohn, Yu Zhang, Oliver Spires, Rongguang Liang

Proceedings Volume 10991, 109910P (2019) https://doi.org/10.1117/12.2518689

KEYWORDS: Metrology, Interferometry, Surface roughness, Optical fabrication, Interferometers, Microscopy, Polarization, Cameras, Diamond turning

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SPIE Journal Paper | 30 April 2019

Dual-mode snapshot interferometric system for on-machine metrology

Xiaobo Tian, Yu Zhang, Alexander Sohn, Oliver Spires, Rongguang Liang

OE, Vol. 58, Issue 04, 044104, (April 2019) https://doi.org/10.1117/12.10.1117/1.OE.58.4.044104

KEYWORDS: Metrology, Interferometry, Calibration, Cameras, Surface roughness, Interferometers, Diamond, Copper, Polymethylmethacrylate, Microscopes

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Proceedings Article | 4 March 2019 Presentation

Miniaturizing stimulated Raman scattering microscopy for human subject investigation (Conference Presentation)

Peng Lin, Shufan Chen, Chien-Sheng Liao, Fengyuan Deng, Oliver Joshua Spires, Yi Zhang, Rongguang Liang, Ji-Xin Cheng

Proceedings Volume 10882, 108821Q (2019) https://doi.org/10.1117/12.2509106

KEYWORDS: In vivo imaging, Raman scattering, Endoscopy, Endoscopes, Microscopy, Chemical analysis, Tissues, Hyperspectral imaging, Raman spectroscopy, Single mode fibers

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SPIE Journal Paper | 8 February 2019

Curl-free ray mapping in three dimensions for freeform illumination design

Caleb Gannon, Rongguang Liang

OE, Vol. 58, Issue 02, 025102, (February 2019) https://doi.org/10.1117/12.10.1117/1.OE.58.2.025102

KEYWORDS: Ray tracing, 3D acquisition, Optical engineering, Geometrical optics, Associative arrays, Freeform optics, Nonimaging optics, Light, Illumination engineering, Optics manufacturing

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SPIE Journal Paper | 7 June 2018

Optimal geometry for off-axis, freeform illumination design

Caleb Gannon, Rongguang Liang

OE, Vol. 57, Issue 06, 065102, (June 2018) https://doi.org/10.1117/12.10.1117/1.OE.57.6.065102

KEYWORDS: Reflection, Reflectivity, Optical engineering, Geometrical optics, Lens design, Light, Ray tracing, Illumination engineering, Optical spheres, Target recognition

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Proceedings Article | 16 May 2018 Paper

Effect of micro-crack and reaction product on laser damage performance of optical glass during chemical etching

Huapan Xiao, Zhi Chen, Hairong Wang, Rongguang Liang, Na Yu, Jiuhong Wang

Proceedings Volume 10713, 1071309 (2018) https://doi.org/10.1117/12.2316622

KEYWORDS: Glasses, Etching, Laser induced damage, Wet etching, Polishing, Surface finishing, Finite-difference time-domain method, Optics manufacturing, Ultrasonics, Laser damage threshold

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Proceedings Article | 16 May 2018 Paper

Combined modulation to incident laser by subsurface crack and contaminant on fused silica

Hairong Wang, Zhi Chen, Huapan Xiao, Rongguang Liang, Na Yu, Jiuhong Wang

Proceedings Volume 10713, 1071312 (2018) https://doi.org/10.1117/12.2316783

KEYWORDS: Modulation, Silica, Reflection, Laser induced damage, Optical components, Scanning electron microscopy, Optics manufacturing, Polishing, Finite-difference time-domain method, Laser scattering

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SPIE Journal Paper | 27 February 2018

Optical design and development of a snapshot light-field laryngoscope

Shuaishuai Zhu, Peng Jin, Rongguang Liang, Liang Gao

OE, Vol. 57, Issue 02, 023110, (February 2018) https://doi.org/10.1117/12.10.1117/1.OE.57.2.023110

KEYWORDS: 3D image processing, 3D image reconstruction, Cameras, 3D acquisition, Image enhancement, Optical design, Detector arrays, Stereoscopy, Image resolution, Spatial resolution

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Proceedings Article | 19 February 2018 Presentation + Paper

Development of a dual-modality, dual-view smartphone-based imaging system for oral cancer detection

Ross Uthoff, Bofan Song, Praveen Birur, Moni Abraham Kuriakose, Sumsum Sunny, Amritha Suresh, Sanjana Patrick, Afarin Anbarani, Oliver Spires, Petra Wilder-Smith, Rongguang Liang

Proceedings Volume 10486, 104860V (2018) https://doi.org/10.1117/12.2296435

KEYWORDS: Imaging systems, Cancer, Cameras, Mouth, Light emitting diodes, Image processing, Biomedical optics, Auto-fluorescence imaging, Mobile device imaging

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Proceedings Article | 23 August 2017 Presentation + Paper

Geometrical error calibration in reflective surface testing based on reverse Hartmann test

Zhidong Gong, Daodang Wang, Ping Xu, Chao Wang, Rongguang Liang, Ming Kong, Jun Zhao, Linhai Mo, Shuhui Mo

Proceedings Volume 10373, 103730K (2017) https://doi.org/10.1117/12.2268372

KEYWORDS: Calibration, Deflectometry, Ray tracing, Reverse modeling

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Proceedings Article | 23 August 2017 Presentation + Paper

General testing method for refractive surfaces based on reverse Hartmann test

Ping Xu, Daodang Wang, Zhidong Gong, Zhongmin Xie, Rongguang Liang, Ming Kong, Jun Zhao, Linhai Mo, Shuhui Mo

Proceedings Volume 10373, 103730J (2017) https://doi.org/10.1117/12.2273189

KEYWORDS: Ray tracing, Wavefronts, Testing and analysis, Glasses, Deflectometry

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Proceedings Article | 26 June 2017 Paper

Fast searching measurement of absolute displacement based on submicron-aperture fiber point-diffraction interferometer

Daodang Wang, Zhichao Wang, Rongguang Liang, Ming Kong, Jun Zhao, Jufeng Zhao, Linhai Mo, Wei Li

Proceedings Volume 10329, 1032937 (2017) https://doi.org/10.1117/12.2268052

KEYWORDS: Particle swarm optimization, 3D modeling, Wavefronts, Reconstruction algorithms, Interferometers, 3D acquisition

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Proceedings Article | 6 June 2017 Presentation

Polarized metrology systems (Conference Presentation)

Rongguang Liang

Proceedings Volume 10220, 1022002 (2017) https://doi.org/10.1117/12.2264881

KEYWORDS: Optical inspection, Inspection, Current controlled current source, Metrology, Polarization, Interferometry, Optical metrology

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Proceedings Article | 6 June 2017 Presentation

On-machine metrology system (Conference Presentation)

Hsiang Nan Cheng, Katherine Overend, Yu Zhang, Rongguang Liang

Proceedings Volume 10220, 102200G (2017) https://doi.org/10.1117/12.2264882

KEYWORDS: Optical metrology, Current controlled current source, Metrology, Colorimetry, Confocal microscopy, Diamond turning, Time metrology, Optical inspection, Inspection

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SPIE Journal Paper | 30 September 2016

Single-image full-focus reconstruction using depth-based deconvolution

Basel Salahieh, Jeffrey Rodriguez, Sean Stetson, Rongguang Liang

OE, Vol. 56, Issue 04, 041302, (September 2016) https://doi.org/10.1117/12.10.1117/1.OE.56.4.041302

KEYWORDS: Deconvolution, Point spread functions, Cameras, Image processing, Visualization, Optical engineering, Image filtering, 3D image processing, Inverse optics, Imaging systems

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Proceedings Article | 26 April 2016 Presentation

Clinical utility of endoscopic OCT: recent advances and future directions (Conference Presentation)

Melissa Suter

Proceedings Volume 9700, 970012 (2016) https://doi.org/10.1117/12.2220766

KEYWORDS: Endoscopy, Optical coherence tomography, Biomedical optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Handheld reflectance confocal endomicroscope for imaging of the oral cavity (Conference Presentation)

Kristen Maitland

Proceedings Volume 9700, 97000V (2016) https://doi.org/10.1117/12.2220764

KEYWORDS: Reflectivity, Confocal microscopy, Biomedical optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Translation of integrated OCT technology from bench to clinical applications (Conference Presentation)

Zhongping Chen

Proceedings Volume 9700, 970011 (2016) https://doi.org/10.1117/12.2220765

KEYWORDS: Optical coherence tomography, Biomedical optics, Integrated optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Reflective Fourier ptychography (Conference Presentation)

Shaun Pacheco, Basel Salahieh, Guoan Zheng, Thomas Milster, Jeffrey Rodriguez, Rongguang Liang

Proceedings Volume 9700, 97000P (2016) https://doi.org/10.1117/12.2236358

KEYWORDS: Reflectivity, Biomedical optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Biological lasers for BIOS (Conference Presentation)

Seok-Hyun Yun

Proceedings Volume 9700, 97000K (2016) https://doi.org/10.1117/12.2220767

KEYWORDS: Biomedical optics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

A compact bio-inspired visible/NIR imager for image-guided surgery (Conference Presentation)

Shengkui Gao, Missael Garcia, Chris Edmiston, Timothy York, Radoslav Marinov, Suman Mondal, Nan Zhu, Gail Sudlow, Walter Akers, Julie Margenthaler, Rongguang Liang, Marta Pepino, Samuel Achilefu, Viktor Gruev

Proceedings Volume 9696, 96960A (2016) https://doi.org/10.1117/12.2214617

KEYWORDS: Imaging systems, Optical filters, Biomimetics, Near infrared, Image-guided intervention, Visual system, Optical sensors, Tumors, Breast cancer, Surgery

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SPIE Journal Paper | 18 February 2016 Open Access

Reflective Fourier ptychography

Shaun Pacheco, Guoan Zheng, Rongguang Liang

JBO, Vol. 21, Issue 02, 026010, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.2.026010

KEYWORDS: Objectives, Reflectivity, Imaging systems, Light emitting diodes, Microscopes, Biomedical optics, Spatial frequencies, Tissues, Inspection, Endoscopy

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SPIE Journal Paper | 7 December 2015

Freeform optics construction with nonuniformly sampled grids in modified double‐pole coordinate system

Donglin Ma, Shaun Pacheco, Chengliang Wang, Rongguang Liang

OE, Vol. 54, Issue 12, 125102, (December 2015) https://doi.org/10.1117/12.10.1117/1.OE.54.12.125102

KEYWORDS: Lens design, Freeform optics, Reflectors, Ray tracing, Light emitting diodes, Light sources, Nonuniform sampling, Reflector design, Optical design, Solids

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SPIE Journal Paper | 10 September 2015 Open Access

Compact wearable dual-mode imaging system for real-time fluorescence image-guided surgery

Nan Zhu, Chih-Yu Huang, Suman Mondal, Shengkui Gao, Chongyuan Huang, Viktor Gruev, Samuel Achilefu, Rongguang Liang

JBO, Vol. 20, Issue 09, 096010, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.096010

KEYWORDS: Imaging systems, Luminescence, Near infrared, Sensors, Goggles, Image-guided intervention, Cameras, Liquid crystals, CMOS sensors, Image sensors

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Proceedings Article | 8 September 2015 Paper

Hybrid freeform TIR optics construction in Cartesian coordinate system: a new composite ray mapping method

Donglin Ma, Zexin Feng, Chengliang Wang, Rongguang Liang

Proceedings Volume 9571, 95710H (2015) https://doi.org/10.1117/12.2190759

KEYWORDS: Ray tracing, Composites, Freeform optics, Geometrical optics, Light emitting diodes, Lens design, Spherical lenses, Hybrid optics, Light, LED lighting

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Proceedings Article | 28 August 2015 Paper

Non-uniformly sampled grids in double pole coordinate system for freeform reflector construction

Donglin Ma, Shaun Pacheco, Zexin Feng, Rongguang Liang

Proceedings Volume 9572, 95720N (2015) https://doi.org/10.1117/12.2190761

KEYWORDS: Reflectors, Ray tracing, Reflector design, Lens design, Computer aided design, Solids, Spherical lenses, Optical spheres, Freeform optics, Light

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SPIE Journal Paper | 15 July 2015 Open Access

Compact dual-view endoscope without field obscuration

Rajender Katkam, Bhaskar Banerjee, Chih-Yu Huang, Xiaoyin Zhu, Luis Ocampo, Jerri-Lynn Kincade, Rongguang Liang

JBO, Vol. 20, Issue 07, 076007, (July 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.7.076007

KEYWORDS: Endoscopes, Objectives, Colon, Prototyping, Endoscopy, Colorectal cancer, Light emitting diodes, Cancer, Waveguides, Lens design

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Proceedings Article | 11 March 2015 Paper

Multifocal confocal spectral microscope

Shaun Pacheco, Rongguang Liang

Proceedings Volume 9315, 93150E (2015) https://doi.org/10.1117/12.2083560

KEYWORDS: Confocal microscopy, Microscopes, Diffraction gratings, Imaging systems, Beam splitters, Kidney, Spectroscopy, Hyperspectral imaging, Mirrors, Tissues

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Proceedings Article | 4 March 2015 Paper

Performance comparison of different compact NIR fluorescent imaging systems with goggle display for intraoperative image-guidance

Shengkui Gao, Suman Mondal, Nan Zhu, Rongguang Liang, Samuel Achilefu, Viktor Gruev

Proceedings Volume 9313, 931304 (2015) https://doi.org/10.1117/12.2079446

KEYWORDS: Cameras, Imaging systems, Near infrared, Luminescence, Optical sensors, Visible radiation, Miniature imaging systems, Sensors, Goggles, Light emitting diodes

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SPIE Journal Paper | 20 January 2015 Open Access

Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system

Shengkui Gao, Suman Mondal, Nan Zhu, RongGuang Liang, Samuel Achilefu, Viktor Gruev

JBO, Vol. 20, Issue 01, 016018, (January 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.1.016018

KEYWORDS: Near infrared, Imaging systems, Luminescence, Light emitting diodes, Visible radiation, Goggles, Optical sensors, Tissues, Surgery, Tumors

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SPIE Journal Paper | 14 October 2014 Open Access

Special Section Guest Editorial: High-Speed 3-D Optical Metrology and Applications

Song Zhang, Rongguang Liang, Lianxiang Yang

OE, Vol. 53, Issue 11, 112201, (October 2014) https://doi.org/10.1117/12.10.1117/1.OE.53.11.112201

KEYWORDS: 3D metrology, Optical metrology, Mechanical engineering, 3D applications, Robotics, Ocean optics, Optics manufacturing, Three dimensional sensing, Biometrics, 3D surface sensing

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Proceedings Article | 19 September 2014 Paper

Tolerancing sub-aperture regions of optical surfaces using circular and elliptical Zernike polynomials

Chih-Yu Huang, Richard Youngworth, Rongguang Liang

Proceedings Volume 9195, 919506 (2014) https://doi.org/10.1117/12.2064787

KEYWORDS: Zernike polynomials, Monte Carlo methods, Aspheric lenses, Tolerancing, Wavefronts, Zemax, Geometrical optics, Beam shaping, Optical simulations, Optical alignment

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SPIE Journal Paper | 24 July 2014 Open Access

Engineering light-emitting diode surgical light for near-infrared fluorescence image-guided surgical systems

Nan Zhu, Suman Mondal, Shengkui Gao, Samuel Achilefu, Viktor Gruev, Rongguang Liang

JBO, Vol. 19, Issue 07, 076018, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.076018

KEYWORDS: Near infrared, Luminescence, Light emitting diodes, Lamps, Mirrors, Optical filters, Radium, Tissue optics, Light sources, Image-guided intervention

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Proceedings Article | 11 March 2014 Paper

System design and evaluation of the array confocal fluorescence microscope

Shaun Pacheco, Tom Milster, Joe Zhou, Rongguang Liang

Proceedings Volume 8936, 89360V (2014) https://doi.org/10.1117/12.2044329

KEYWORDS: Confocal microscopy, Microscopes, Objectives, Luminescence, Diffraction gratings, Beam splitters, Head, Imaging systems, Diamond turning, Optical alignment

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Proceedings Article | 4 March 2014 Paper

Intraoperative imaging and fluorescence image guidance in oncologic surgery using a wearable fluorescence goggle system

Suman Mondal, Shengkui Gao, Nan Zhu, Yang Liu, Gail Sudlow, Walter Akers, Rongguang Liang, Viktor Gruev, Samuel Achilefu

Proceedings Volume 8936, 89360P (2014) https://doi.org/10.1117/12.2039903

KEYWORDS: Imaging systems, Surgery, Goggles, Luminescence, Tumors, Tissues, Near infrared, Cancer, Head-mounted displays, Visualization

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SPIE Journal Paper | 21 January 2014

Short wavelength and polarized phase shifting fringe projection imaging of translucent objects

Rongguang Liang

OE, Vol. 53, Issue 01, 014104, (January 2014) https://doi.org/10.1117/12.10.1117/1.OE.53.1.014104

KEYWORDS: Phase shifting, Translucency, Light scattering, Polarization, Teeth, 3D image processing, Scattering, Cameras, Optical engineering, Polarizers

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Proceedings Article | 13 March 2013 Paper

Real-time multispectral diffuse optical tomography system for imaging epileptic activity and connectivity

Tao Zhang, Jianjun Yang, Junli Zhou, Hao Yang, Paul Carney, Huabei Jiang

Proceedings Volume 8573, 857305 (2013) https://doi.org/10.1117/12.2009595

KEYWORDS: Light emitting diodes, Imaging systems, Hemodynamics, Sensors, Electroencephalography, Brain, In vivo imaging, 3D image processing, Signal detection, Field programmable gate arrays

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SPIE Press Book | 24 January 2011

Optical Design for Biomedical Imaging

Rongguang Liang

KEYWORDS: Objectives, Imaging systems, Monochromatic aberrations, Polarization, Tissues, Mirrors, Relays, Confocal microscopy, Light sources

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Proceedings Article | 12 February 2008 Paper

Optical design of a multimodal imaging system

Rongguang Liang, Victor Wong, Paul McLaughlin

Proceedings Volume 6849, 684908 (2008) https://doi.org/10.1117/12.764751

KEYWORDS: Imaging systems, Teeth, Optical coherence tomography, Luminescence, Reflectivity, Dental caries, Multimodal imaging, Mirrors, Coherence imaging, Optical design

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Proceedings Article | 21 September 2007 Paper

High numerical aperture line scanning system

Rongguang Liang

Proceedings Volume 6668, 66680I (2007) https://doi.org/10.1117/12.727615

KEYWORDS: Image segmentation, Sensors, Image sensors, Image processing, Modulation transfer functions, Head, Optical scanning, Imaging systems, Reflection, Optical scanning systems

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Proceedings Article | 9 February 2007 Paper

Multimodal imaging system for dental caries detection

Rongguang Liang, Victor Wong, Michael Marcus, Peter Burns, Paul McLaughlin

Proceedings Volume 6425, 642502 (2007) https://doi.org/10.1117/12.702131

KEYWORDS: Teeth, Optical coherence tomography, Luminescence, Dental caries, Imaging systems, Reflectivity, Multimodal imaging, Minerals, Reflection, Light sources

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Proceedings Article | 10 January 2002 Paper

Optical characterization of multilayer stacks for phase-change media

Rongguang Liang, Chubing Peng, Kenichi Nagata, Kelly Daly Flynn, Masud Mansuripur

Proceedings Volume 4342, (2002) https://doi.org/10.1117/12.453427

KEYWORDS: Dielectrics, Aluminum, Multilayers, Reflectivity, Optical recording, Crystals, Manufacturing, Optical testing, Reflection, Interfaces

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SPIE Journal Paper | 1 July 2000

Optical modeling combining geometrical ray tracing and physical-optics software

John Tesar, Rongguang Liang, Masud Mansuripur

OE, Vol. 39, Issue 07, (July 2000) https://doi.org/10.1117/12.10.1117/1.602567

KEYWORDS: Optical spheres, Lens design, Geometrical optics, Ray tracing, Fringe analysis, Mirrors, Glasses, Wavefronts, Spherical lenses, Interferometry

Showing 5 of 81 publications

Proceedings Volume Editor (14)

SPIE Conference Volume | 4 April 2019

Design and Quality for Biomedical Technologies XII

SPIE Conference Volume | 11 May 2018

Design and Quality for Biomedical Technologies XI

SPIE Conference Volume | 12 April 2017

Design and Quality for Biomedical Technologies X

SPIE Conference Volume | 8 July 2016

Design and Quality for Biomedical Technologies IX

SPIE Conference Volume | 9 April 2015

Design and Quality for Biomedical Technologies VIII

Showing 5 of 14 publications

Conference Committee Involvement (41)

Dimensional Optical Metrology and Inspection for Practical Applications XIV

16 April 2025 | Orlando, Florida, United States

Dimensional Optical Metrology and Inspection for Practical Applications XIII

24 April 2024 | National Harbor, Maryland, United States

Dimensional Optical Metrology and Inspection for Practical Applications XII

2 May 2023 | Orlando, Florida, United States

Design and Quality for Biomedical Technologies XVI

28 January 2023 | San Francisco, California, United States

Dimensional Optical Metrology and Inspection for Practical Applications XI

5 April 2022 | Orlando, Florida, United States

Design and Quality for Biomedical Technologies XV

22 January 2022 | San Francisco, California, United States

Optical Design and Testing XI

10 October 2021 | Nantong, JS, China

Dimensional Optical Metrology and Inspection for Practical Applications X

12 April 2021 | Online Only, Florida, United States

Design and Quality for Biomedical Technologies XIV

6 March 2021 | Online Only, California, United States

Optical Design and Testing X

12 October 2020 | Online Only, China

Dimensional Optical Metrology and Inspection for Practical Applications IX

27 April 2020 | Online Only, California, United States

Dimensional Optical Metrology and Inspection for Practical Applications VIII

16 April 2019 | Baltimore, MD, United States

Design and Quality for Biomedical Technologies XII

2 February 2019 | San Francisco, California, United States

Dimensional Optical Metrology and Inspection for Practical Applications VII

18 April 2018 | Orlando, FL, United States

Design and Quality for Biomedical Technologies XI

27 January 2018 | San Francisco, California, United States

Light in Nature VI

7 August 2017 | San Diego, California, United States

Dimensional Optical Metrology and Inspection for Practical Applications VI

13 April 2017 | Anaheim, CA, United States

Design and Quality for Biomedical Technologies X

28 January 2017 | San Francisco, California, United States

Design and Quality for Biomedical Technologies IX

13 February 2016 | San Francisco, California, United States

Design and Quality for Biomedical Technologies VIII

7 February 2015 | San Francisco, California, United States

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII

7 February 2015 | San Francisco, California, United States

The Nature of Light: Light in Nature V

18 August 2014 | San Diego, California, United States

SPIE Translational Biophotonics 2014

19 May 2014 | Houston, Texas, United States

Design and Quality for Biomedical Technologies VII

1 February 2014 | San Francisco, California, United States

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI

1 February 2014 | San Francisco, California, United States

Novel Optical Systems Design and Optimization XVI

27 August 2013 | San Diego, California, United States

Design and Quality for Biomedical Technologies VI

2 February 2013 | San Francisco, California, United States

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V

2 February 2013 | San Francisco, California, United States

Novel Optical Systems Design and Optimization XV

15 August 2012 | San Diego, California, United States

The Nature of Light: Light in Nature IV

13 August 2012 | San Diego, California, United States

Design and Quality for Biomedical Technologies V

22 January 2012 | San Francisco, California, United States

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV

21 January 2012 | San Francisco, California, United States

Novel Optical Systems Design and Optimization XIV

22 August 2011 | San Diego, California, United States

Design and Quality for Biomedical Technologies IV

24 January 2011 | San Francisco, California, United States

Novel Optical Systems Design and Optimization XIII

3 August 2010 | San Diego, California, United States

Design and Quality for Biomedical Technologies III

25 January 2010 | San Francisco, California, United States

Novel Optical Systems Design and Optimization XII

3 August 2009 | San Diego, California, United States

Design and Quality for Biomedical Technologies II

26 January 2009 | San Jose, California, United States

Novel Optical Systems Design and Optimization XI

13 August 2008 | San Diego, California, United States

Design and Quality for Biomedical Technologies

21 January 2008 | San Jose, California, United States

Novel Optical Systems Design and Optimization X

28 August 2007 | San Diego, California, United States

Showing 5 of 41 Conference Committees

Course Instructor

SC868: Optical Design for Biomedical Imaging

This course provides attendees with a basic working knowledge of optical design for biomedical imaging. The course will begin with the fundamentals of biomedical optics, followed by light sources, detectors, and other optical components for biomedical imaging. The course will focus on optical systems and techniques for different imaging modalities.

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